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Background Large language models (LLMs) are increasingly deployed in medical consultations, yet their safety under realistic user pressures remains understudied. Prior assessments focused on neutral conditions, overlooking vulnerabilities…

Computation and Language · Computer Science 2026-01-16 Vahideh Zolfaghari

The paper introduces a framework for the evaluation of the encoding of factual scientific knowledge, designed to streamline the manual evaluation process typically conducted by domain experts. Inferring over and extracting information from…

Computation and Language · Computer Science 2024-10-21 Magdalena Wysocka , Oskar Wysocki , Maxime Delmas , Vincent Mutel , Andre Freitas

Across medical specialties, clinical practice is anchored in evidence-based guidelines that codify best studied diagnostic and treatment pathways. These pathways routinely fall short for the long tail of real-world care not covered by…

Ensuring alignment, which refers to making models behave in accordance with human intentions [1,2], has become a critical task before deploying large language models (LLMs) in real-world applications. For instance, OpenAI devoted six months…

Artificial Intelligence · Computer Science 2024-03-22 Yang Liu , Yuanshun Yao , Jean-Francois Ton , Xiaoying Zhang , Ruocheng Guo , Hao Cheng , Yegor Klochkov , Muhammad Faaiz Taufiq , Hang Li

In recent years, the application of Large Language Models (LLMs) in healthcare has shown significant promise in improving the accessibility and dissemination of medical knowledge. This paper presents a detailed study of various LLMs trained…

Computation and Language · Computer Science 2024-08-09 Haoran Yu , Chang Yu , Zihan Wang , Dongxian Zou , Hao Qin

Evaluating natural language generation (NLG) systems in the medical domain presents unique challenges due to the critical demands for accuracy, relevance, and domain-specific expertise. Traditional automatic evaluation metrics, such as…

Computation and Language · Computer Science 2025-09-17 Wen-wai Yim , Asma Ben Abacha , Zixuan Yu , Robert Doerning , Fei Xia , Meliha Yetisgen

The potential of Multimodal Large Language Models (MLLMs) in domain of medical imaging raise the demands of systematic and rigorous evaluation frameworks that are aligned with the real-world medical imaging practice. Existing practices that…

Computation and Language · Computer Science 2026-04-16 Zhijie Bao , Fangke Chen , Licheng Bao , Chenhui Zhang , Wei Chen , Jiajie Peng , Zhongyu Wei

Large Language Models (LLMs) represent a major step toward artificial general intelligence, significantly advancing our ability to interact with technology. While LLMs perform well on Natural Language Processing tasks -- such as…

Computation and Language · Computer Science 2025-05-15 Brandon Smith , Mohamed Reda Bouadjenek , Tahsin Alamgir Kheya , Phillip Dawson , Sunil Aryal

Evaluating large language models (LLMs) for medical applications remains challenging due to benchmark saturation, limited data accessibility, and insufficient coverage of relevant tasks. Existing suites have either saturated, heavily depend…

With the increasing use of large language models (LLMs) in medical decision-support, it is essential to evaluate not only their final answers but also the reliability of their reasoning. Two key risks are Chain-of-Thought (CoT) faithfulness…

Computer Vision and Pattern Recognition · Computer Science 2025-08-25 Kaiyuan Ji , Yijin Guo , Zicheng Zhang , Xiangyang Zhu , Yuan Tian , Ning Liu , Guangtao Zhai

Medical large language models (LLMs) achieve impressive performance on standardized benchmarks, yet these evaluations fail to capture the complexity of real clinical encounters where patients exhibit memory gaps, limited health literacy,…

Artificial Intelligence · Computer Science 2026-04-14 Sina Mansouri , Mohit Marvania , Vibhavari Ashok Shihorkar , Han Ngoc Tran , Kazhal Shafiei , Mehrdad Fazli , Yikuan Li , Ziwei Zhu

Large Language Models (LLMs) are increasingly deployed in real-world applications where users engage in extended, mixed-topic conversations that depend on prior context. Yet, their reliability under realistic multi-turn interactions remains…

Computation and Language · Computer Science 2026-03-03 Jiyoon Myung

The emergence of large language models (LLMs) has significantly influenced numerous fields, including healthcare, by enhancing the capabilities of automated systems to process and generate human-like text. However, despite their…

Information Retrieval · Computer Science 2025-04-23 Mohit Gupta , Akiko Aizawa , Rajiv Ratn Shah

Large Language Models (LLMs) often produce explanations that do not faithfully reflect the factors driving their predictions. In healthcare settings, such unfaithfulness is especially problematic: explanations that omit salient clinical…

Computation and Language · Computer Science 2025-11-04 Teague McMillan , Gabriele Dominici , Martin Gjoreski , Marc Langheinrich

The proliferation of Large Language Models (LLMs) in medicine has enabled impressive capabilities, yet a critical gap remains in their ability to perform systematic, transparent, and verifiable reasoning, a cornerstone of clinical practice.…

Computation and Language · Computer Science 2025-08-04 Wenxuan Wang , Zizhan Ma , Meidan Ding , Shiyi Zheng , Shengyuan Liu , Jie Liu , Jiaming Ji , Wenting Chen , Xiang Li , Linlin Shen , Yixuan Yuan

Large language models (LLMs) are transforming the ways the general public accesses and consumes information. Their influence is particularly pronounced in pivotal sectors like healthcare, where lay individuals are increasingly appropriating…

Computation and Language · Computer Science 2023-10-24 Yiqiao Jin , Mohit Chandra , Gaurav Verma , Yibo Hu , Munmun De Choudhury , Srijan Kumar

Large language models (LLMs) hold great promise in summarizing medical evidence. Most recent studies focus on the application of proprietary LLMs. Using proprietary LLMs introduces multiple risk factors, including a lack of transparency and…

In the face of rapidly expanding online medical literature, automated systems for aggregating and summarizing information are becoming increasingly crucial for healthcare professionals and patients. Large Language Models (LLMs), with their…

Computation and Language · Computer Science 2024-03-07 Niraj Yagnik , Jay Jhaveri , Vivek Sharma , Gabriel Pila

Accurate and efficient question-answering systems are essential for delivering high-quality patient care in the medical field. While Large Language Models (LLMs) have made remarkable strides across various domains, they continue to face…

Computation and Language · Computer Science 2025-01-22 Hang Yang , Hao Chen , Hui Guo , Yineng Chen , Ching-Sheng Lin , Shu Hu , Jinrong Hu , Xi Wu , Xin Wang

Large Language Models (LLMs) are now widely used for query reformulation and expansion in Information Retrieval, with many studies reporting substantial effectiveness gains. However, these results are typically obtained under heterogeneous…

Information Retrieval · Computer Science 2026-05-01 Amin Bigdeli , Radin Hamidi Rad , Hai Son Le , Mert Incesu , Negar Arabzadeh , Charles L. A. Clarke , Ebrahim Bagheri
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