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The rapid growth of medical knowledge and increasing complexity of clinical practice pose challenges. In this context, large language models (LLMs) have demonstrated value; however, inherent limitations remain. Retrieval-augmented…

Electronic health records (EHRs) are long, noisy, and often redundant, posing a major challenge for the clinicians who must navigate them. Large language models (LLMs) offer a promising solution for extracting and reasoning over this…

Computation and Language · Computer Science 2025-08-21 Skatje Myers , Dmitriy Dligach , Timothy A. Miller , Samantha Barr , Yanjun Gao , Matthew Churpek , Anoop Mayampurath , Majid Afshar

Retrieval-augmented generation (RAG) enhances large language models (LLMs) by incorporating external knowledge. Current hybrid RAG system retrieves evidence from both knowledge graphs (KGs) and text documents to support LLM reasoning.…

Computation and Language · Computer Science 2025-09-22 Xingyu Tan , Xiaoyang Wang , Qing Liu , Xiwei Xu , Xin Yuan , Liming Zhu , Wenjie Zhang

Retrieval-Augmented Generation (RAG) quality depends on many interacting choices across retrieval, ranking, augmentation, prompting, and generation, so optimizing modules in isolation is brittle. We introduce RAGSmith, a modular framework…

Computation and Language · Computer Science 2025-11-04 Muhammed Yusuf Kartal , Suha Kagan Kose , Korhan Sevinç , Burak Aktas

Recent advancements in table-based reasoning have expanded beyond factoid-level QA to address insight-level tasks, where systems should synthesize implicit knowledge in the table to provide explainable analyses. Although effective, existing…

Computation and Language · Computer Science 2025-06-03 Kwangwook Seo , Donguk Kwon , Dongha Lee

Medical Question Answering systems based on Retrieval Augmented Generation is promising for clinical decision support because they can integrate external knowledge, thus reducing inaccuracies inherent in standalone large language models…

Computation and Language · Computer Science 2025-03-28 Yuelyu Ji , Hang Zhang , Yanshan Wang

The increasing complexity of clinical decision-making, alongside the rapid expansion of electronic health records (EHR), presents both opportunities and challenges for delivering data-informed care. This paper proposes a clinical decision…

Artificial Intelligence · Computer Science 2025-10-03 Leon Garza , Anantaa Kotal , Michael A. Grasso , Emre Umucu

Background: Cognitive biases in clinical decision-making significantly contribute to errors in diagnosis and suboptimal patient outcomes. Addressing these biases presents a formidable challenge in the medical field. Objective: This study…

Computation and Language · Computer Science 2024-05-14 Yu He Ke , Rui Yang , Sui An Lie , Taylor Xin Yi Lim , Hairil Rizal Abdullah , Daniel Shu Wei Ting , Nan Liu

Background: Several studies show that large language models (LLMs) struggle with phenotype-driven gene prioritization for rare diseases. These studies typically use Human Phenotype Ontology (HPO) terms to prompt foundation models like GPT…

Computation and Language · Computer Science 2026-02-19 Zhanliang Wang , Da Wu , Quan Nguyen , Kai Wang

Retrieval-augmented generation (RAG) grounds large language models in external medical knowledge, yet standard retrievers frequently surface hard negatives that are semantically close to the query but describe clinically distinct…

Information Retrieval · Computer Science 2026-04-07 Byeolhee Kim , Min-Kyung Kim , Young-Hak Kim , Tae-Joon Jeon

Radiology Report Generation (RRG) through Vision-Language Models (VLMs) promises to reduce documentation burden, improve reporting consistency, and accelerate clinical workflows. However, their clinical adoption remains limited by the lack…

Computer Vision and Pattern Recognition · Computer Science 2026-02-18 Marco Salmè , Federico Siciliano , Fabrizio Silvestri , Paolo Soda , Rosa Sicilia , Valerio Guarrasi

Detecting harmful content in multi turn dialogue requires reasoning over the full conversational context rather than isolated utterances. However, most existing methods rely mainly on models internal parametric knowledge, without explicit…

Computation and Language · Computer Science 2026-04-21 Juhyeon Lee , Wonduk Seo , Junseo Koh , Seunghyun Lee , Haihua Chen , Yi Bu

Large Language Models (LLMs) have shown promising performance on diverse medical benchmarks, highlighting their potential in supporting real-world clinical tasks. Retrieval-Augmented Generation (RAG) has emerged as a key approach for…

Computation and Language · Computer Science 2025-09-30 Kaishuai Xu , Wenjun Hou , Yi Cheng , Wenjie Li

Incident response (IR) requires fast, coordinated, and well-informed decision-making to contain and mitigate cyber threats. While large language models (LLMs) have shown promise as autonomous agents in simulated IR settings, their reasoning…

Computation and Language · Computer Science 2025-10-07 Zefang Liu , Arman Anwar

As artificial intelligence permeates judicial forensics, ensuring the veracity and traceability of legal question answering (QA) has become critical. Conventional large language models (LLMs) are prone to hallucination, risking misleading…

Artificial Intelligence · Computer Science 2025-11-18 Yueqing Xi , Yifan Bai , Huasen Luo , Weiliang Wen , Hui Liu , Haoliang Li

Large language models are increasingly being assembled into medical multi-agent systems that emulate multidisciplinary consultation through specialist roles, peer review and consensus formation. In clinical decision support, however,…

Computation and Language · Computer Science 2026-05-28 Yinghao Zhu , Lei Gu , Zixiang Wang , Haoran Sang , Dehao Sui , Wen Tang , Lan Mi , Yasha Wang , Junyi Gao , Liang Yao , Tianfan Fu , Ewen Harrison , Lequan Yu , Liantao Ma

Large Language Models (LLMs) are increasingly applied in healthcare, yet ensuring their ethical integrity and safety compliance remains a major barrier to clinical deployment. This work introduces a multi-agent refinement framework designed…

Retrieval-Augmented Generation (RAG) has emerged as a powerful paradigm to enhance large language models (LLMs) by conditioning generation on external evidence retrieved at inference time. While RAG addresses critical limitations of…

Information Retrieval · Computer Science 2025-06-03 Chaitanya Sharma

Retrieval-augmented generation (RAG) has shown impressive capabilities in mitigating hallucinations in large language models (LLMs). However, LLMs struggle to maintain consistent reasoning when exposed to misleading or conflicting evidence,…

Artificial Intelligence · Computer Science 2026-01-21 Linda Zeng , Rithwik Gupta , Divij Motwani , Yi Zhang , Diji Yang

Recent advances in large language models (LLMs) have shown great potential to accelerate drug discovery. However, the specialized nature of biochemical data often necessitates costly domain-specific fine-tuning, posing major challenges.…

Machine Learning · Computer Science 2025-11-17 Namkyeong Lee , Edward De Brouwer , Ehsan Hajiramezanali , Tommaso Biancalani , Chanyoung Park , Gabriele Scalia
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