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Multimodal Large Language Models (MLLMs) in healthcare suffer from severe confirmation bias, often hallucinating visual details to support initial, potentially erroneous diagnostic hypotheses. Existing Chain-of-Thought (CoT) approaches lack…

Computation and Language · Computer Science 2026-04-14 Zhixiang Lu , Jionglong Su

In this work, we introduce MedAgentSim, an open-source simulated clinical environment with doctor, patient, and measurement agents designed to evaluate and enhance LLM performance in dynamic diagnostic settings. Unlike prior approaches, our…

Computation and Language · Computer Science 2025-10-02 Mohammad Almansoori , Komal Kumar , Hisham Cholakkal

There is vivid research on adapting Large Language Models (LLMs) to perform a variety of tasks in high-stakes domains such as healthcare. Despite their popularity, there is a lack of understanding of the extent and contributing factors that…

Computation and Language · Computer Science 2024-06-07 Anand Subramanian , Viktor Schlegel , Abhinav Ramesh Kashyap , Thanh-Tung Nguyen , Vijay Prakash Dwivedi , Stefan Winkler

Current evaluation of large language models (LLMs) overwhelmingly prioritizes accuracy; however, in real-world and safety-critical applications, the ability to abstain when uncertain is equally vital for trustworthy deployment. We introduce…

Computation and Language · Computer Science 2026-01-23 Sravanthi Machcha , Sushrita Yerra , Sahil Gupta , Aishwarya Sahoo , Sharmin Sultana , Hong Yu , Zonghai Yao

With appropriate data selection and training techniques, Large Language Models (LLMs) have demonstrated exceptional success in various medical examinations and multiple-choice questions. However, the application of LLMs in medical dialogue…

Computation and Language · Computer Science 2024-03-12 Jiageng Wu , Xian Wu , Yefeng Zheng , Jie Yang

With the proliferation of Large Language Models (LLMs) in diverse domains, there is a particular need for unified evaluation standards in clinical medical scenarios, where models need to be examined very thoroughly. We present CliMedBench,…

Computation and Language · Computer Science 2024-10-07 Zetian Ouyang , Yishuai Qiu , Linlin Wang , Gerard de Melo , Ya Zhang , Yanfeng Wang , Liang He

MedCalc-Bench is a widely used benchmark for evaluating LLM performance on clinical calculator tasks, with state-of-the-art direct prompting scores plateauing around 35% on the Verified split (HELM MedHELM leaderboard) and the best…

Machine Learning · Computer Science 2026-03-04 Artus Krohn-Grimberghe

Clinical document classification is essential for converting unstructured medical texts into standardised ICD-10 diagnoses, yet it faces challenges due to complex medical language, privacy constraints, and limited annotated datasets. Large…

Computation and Language · Computer Science 2026-02-03 Akram Mustafa , Usman Naseem , Mostafa Rahimi Azghadi

Multimodal in-context learning (ICL) remains underexplored despite significant potential for domains such as medicine. Clinicians routinely encounter diverse, specialized tasks requiring adaptation from limited examples, such as drawing…

Global healthcare providers are exploring use of large language models (LLMs) to provide medical advice to the public. LLMs now achieve nearly perfect scores on medical licensing exams, but this does not necessarily translate to accurate…

Autonomous agents utilizing Large Language Models (LLMs) have demonstrated remarkable capabilities in isolated medical tasks like diagnosis and image analysis, but struggle with integrated clinical workflows that connect diagnostic…

Artificial Intelligence · Computer Science 2025-10-14 Hongjie Zheng , Zesheng Shi , Ping Yi

Medical vision--language models (VLMs) have shown strong potential for medical visual question answering (VQA), yet their reasoning remains largely text-centric: images are encoded once as static context, and subsequent inference is…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Suyang Xi , Songtao Hu , Yuxiang Lai , Wangyun Dan , Yaqi Liu , Shansong Wang , Xiaofeng Yang

Effective patient communication is pivotal in healthcare, yet traditional medical training often lacks exposure to diverse, challenging interpersonal dynamics. To bridge this gap, this study proposes the use of Large Language Models (LLMs)…

Medical question answering (QA) benchmarks often focus on multiple-choice or fact-based tasks, leaving open-ended answers to real patient questions underexplored. This gap is particularly critical in mental health, where patient questions…

Computation and Language · Computer Science 2026-05-15 Yahan Li , Jifan Yao , John Bosco S. Bunyi , Adam C. Frank , Angel Hsing-Chi Hwang , Ruishan Liu

Clinician-facing predictive models are increasingly present in the healthcare setting. Regardless of their success with respect to performance metrics, all models have uncertainty. We investigate how to visually communicate uncertainty in…

Human-Computer Interaction · Computer Science 2022-10-25 Caitlin F. Harrigan , Gabriela Morgenshtern , Anna Goldenberg , Fanny Chevalier

Recent progress in multimodal large language models (MLLMs) has demonstrated promising performance on medical benchmarks and in preliminary trials as clinical assistants. Yet, our pilot audit of diagnostic cases uncovers a critical failure…

Artificial Intelligence · Computer Science 2025-09-30 Hongjun Liu , Yinghao Zhu , Yuhui Wang , Yitao Long , Zeyu Lai , Lequan Yu , Chen Zhao

Recent multimodal large language models (MLLMs) have demonstrated significant potential in open-ended conversation, generating more accurate and personalized responses. However, their abilities to memorize, recall, and reason in sustained…

Many benchmarks for automated causal inference evaluate a system's performance based on a single numerical output, such as an Average Treatment Effect (ATE). This approach conflates two distinct steps in causal analysis: identification -…

Artificial Intelligence · Computer Science 2026-05-15 Ayush Sawarni , Jiyuan Tan , Vasilis Syrgkanis

In high-stakes medical applications, consistent answering across diverse question phrasings is essential for reliable diagnosis. However, we reveal that current Medical Vision-Language Models (Med-VLMs) exhibit concerning fragility in…

Computation and Language · Computer Science 2025-08-27 Songtao Jiang , Yuxi Chen , Sibo Song , Yan Zhang , Yeying Jin , Yang Feng , Jian Wu , Zuozhu Liu

Large Language Models (LLMs) have shown strong potential in complex medical reasoning yet face diminishing gains under inference scaling laws. While existing studies augment LLMs with various knowledge types, it remains unclear how…

Artificial Intelligence · Computer Science 2026-02-10 Yu Zhao , Hao Guan , Yongcheng Jing , Ying Zhang , Dacheng Tao