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Large Language Models (LLMs) are increasingly applied to medicine, yet their adoption is limited by concerns over reliability and safety. Existing evaluations either test factual medical knowledge in isolation or assess patient-level…

Computation and Language · Computer Science 2026-05-08 Zhan Qu , Michael Färber

Existing benchmarks for Large Language Model (LLM) agents focus on task completion under idealistic settings but overlook reliability in real-world, user-facing applications. In domains, such as in-car voice assistants, users often issue…

Artificial Intelligence · Computer Science 2026-01-30 Johannes Kirmayr , Lukas Stappen , Elisabeth André

Simulations constitute a fundamental component of medical and nursing education and traditionally employ standardized patients (SP) and high-fidelity manikins to develop clinical reasoning and communication skills. However, these methods…

Human-Computer Interaction · Computer Science 2025-10-23 Akilan Amithasagaran , Sagnik Dakshit , Bhavani Suryadevara , Lindsey Stockton

Large language models in healthcare often produce emotionally flat or opaque responses, failing to provide the transparent reasoning required for clinical trust. We present RECAP (Reflect-Extract-Calibrate-Align-Produce), an inference-time…

Computation and Language · Computer Science 2026-05-05 Adarsh Srinivasan , Jacob Dineen , Muhammad Umar Afzal , Muhammad Uzair Sarfraz , Irbaz B. Riaz , Ben Zhou

Medicine is rife with high-stakes uncertainty. Doctors routinely make clinical judgments and decisions that juggle many fundamental unknowns, like predictions about what might be causing a patients' symptoms or decisions about what…

Sycophancy, an excessive tendency of AI models to agree with user input at the expense of factual accuracy or in contradiction of visual evidence, poses a critical and underexplored challenge for multimodal large language models (MLLMs).…

Artificial Intelligence · Computer Science 2025-12-23 A. B. M. Ashikur Rahman , Saeed Anwar , Muhammad Usman , Irfan Ahmad , Ajmal Mian

We present MEDCOD, a Medically-Accurate, Emotive, Diverse, and Controllable Dialog system with a unique approach to the natural language generator module. MEDCOD has been developed and evaluated specifically for the history taking task. It…

Computation and Language · Computer Science 2021-11-19 Rhys Compton , Ilya Valmianski , Li Deng , Costa Huang , Namit Katariya , Xavier Amatriain , Anitha Kannan

Large language models (LLMs) excel in various NLP tasks and modern medicine, but their evaluation in traditional Chinese medicine (TCM) is underexplored. To address this, we introduce TCM3CEval, a benchmark assessing LLMs in TCM across…

Computation and Language · Computer Science 2025-03-11 Tianai Huang , Lu Lu , Jiayuan Chen , Lihao Liu , Junjun He , Yuping Zhao , Wenchao Tang , Jie Xu

Automatically reasoning with conflicting generic clinical guidelines is a burning issue in patient-centric medical reasoning where patient-specific conditions and goals need to be taken into account. It is even more challenging in the…

Artificial Intelligence · Computer Science 2019-02-21 Kristijonas Čyras , Tiago Oliveira

Clinical decisions are often required under incomplete information. Clinical experts must identify whether available information is sufficient for judgment, as both premature conclusion and unnecessary abstention can compromise patient…

Artificial Intelligence · Computer Science 2026-02-27 Yusuke Watanabe , Yohei Kobashi , Takeshi Kojima , Yusuke Iwasawa , Yasushi Okuno , Yutaka Matsuo

Large language models (LLMs) are starting to complement traditional information seeking mechanisms such as web search. LLM-powered chatbots like ChatGPT are gaining prominence among the general public. AI chatbots are also increasingly…

Computation and Language · Computer Science 2025-11-25 Vibhor Agarwal , Yiqiao Jin , Mohit Chandra , Munmun De Choudhury , Srijan Kumar , Nishanth Sastry

In a doctor-patient dialogue, the primary objective of physicians is to diagnose patients and propose a treatment plan. Medical doctors guide these conversations through targeted questioning to efficiently gather the information required to…

Computation and Language · Computer Science 2025-08-27 Tom Röhr , Soumyadeep Roy , Fares Al Mohamad , Jens-Michalis Papaioannou , Wolfgang Nejdl , Felix Gers , Alexander Löser

Large vision-language models (LVLMs) demonstrate strong performance in dermatology; however, evaluating diagnostic reasoning for rare conditions remains largely unexplored. Existing benchmarks focus on common diseases and assess only final…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Yang Liu , Jiyao Yang , Hongjin Zhao , Xiaoyong Li , Yanzhe Ji , Xingjian Li , Runmin Jiang , Tianyang Wang , Saeed Anwar , Dongwoo Kim , Yue Yao , Zhenyue Qin , Min Xu

The rise of large language models (LLMs) has transformed healthcare by offering clinical guidance, yet their direct deployment to patients poses safety risks due to limited domain expertise. To mitigate this, we propose repositioning LLMs…

Computation and Language · Computer Science 2025-10-14 Wenya Xie , Qingying Xiao , Yu Zheng , Xidong Wang , Junying Chen , Ke Ji , Anningzhe Gao , Prayag Tiwari , Xiang Wan , Feng Jiang , Benyou Wang

Automatic depression detection from doctor-patient conversations has gained momentum thanks to the availability of public corpora and advances in language modeling. However, interpretability remains limited: strong performance is often…

Large Language Models (LLMs) have demonstrated impressive capabilities across various specialist domains and have been integrated into high-stakes areas such as medicine. However, as existing medical-related benchmarks rarely stress-test…

Computation and Language · Computer Science 2026-03-26 Lin Yang , Yuancheng Yang , Xu Wang , Changkun Liu , Haihua Yang

Explaining Deep Learning models is becoming increasingly important in the face of daily emerging multimodal models, particularly in safety-critical domains like medical imaging. However, the lack of detailed investigations into the…

Computer Vision and Pattern Recognition · Computer Science 2024-03-29 Anees Ur Rehman Hashmi , Dwarikanath Mahapatra , Mohammad Yaqub

As Vision-Language Models (VLMs) increasingly gain traction in medical applications, clinicians are progressively expecting AI systems not only to generate textual diagnoses but also to produce corresponding medical images that integrate…

Computer Vision and Pattern Recognition · Computer Science 2025-11-19 Junjie Yang , Yuhao Yan , Gang Wu , Yuxuan Wang , Ruoyu Liang , Xinjie Jiang , Xiang Wan , Fenglei Fan , Yongquan Zhang , Feiwei Qin , Changmiao Wang

Inpatient clinical reasoning is a sequential decision under partial observability: the clinician sees the admission so far and must choose the next action whose downstream consequences are not yet visible. Existing clinical-LLM evaluations…

Computation and Language · Computer Science 2026-05-12 Aishik Nagar , Arun-Kumar Kaliya-Perumal , Yu-Hsuan Han , Andrew Sheng-Han Huang , Kristen Kee , Yushi Cao , Yiming Chen , Hongchao Jiang

Real-world health questions from patients often unintentionally embed false assumptions or premises. In such cases, safe medical communication typically involves redirection: addressing the implicit misconception and then responding to the…

Computation and Language · Computer Science 2026-04-21 Sraavya Sambara , Yuan Pu , Ayman Ali , Vishala Mishra , Lionel Wong , Monica Agrawal
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