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Background: Large language models (LLMs) show promise in medicine, but their deployment in hospitals is limited by restricted access to electronic health record (EHR) systems. The Model Context Protocol (MCP) enables integration between…

Artificial Intelligence · Computer Science 2025-09-22 Kanato Masayoshi , Masahiro Hashimoto , Ryoichi Yokoyama , Naoki Toda , Yoshifumi Uwamino , Shogo Fukuda , Ho Namkoong , Masahiro Jinzaki

The Model Context Protocol (MCP) is a recently proposed interoperability standard that unifies how AI agents connect with external tools and data sources. By defining a set of common client-server message exchange clauses, MCP replaces…

Cryptography and Security · Computer Science 2026-03-12 Nanzi Yang , Weiheng Bai , Kangjie Lu

The Model Context Protocol (MCP) has emerged as a de facto standard for integrating Large Language Models with external tools, yet no formal security analysis of the protocol specification exists. We present the first rigorous security…

Cryptography and Security · Computer Science 2026-01-27 Narek Maloyan , Dmitry Namiot

The Model Context Protocol (MCP) has been proposed as a unifying standard for connecting large language models (LLMs) with external tools and resources, promising the same role for AI integration that HTTP and USB played for the Web and…

Computers and Society · Computer Science 2025-11-18 Hechuan Guo , Yongle Hao , Yue Zhang , Minghui Xu , Peizhuo Lv , Jiezhi Chen , Xiuzhen Cheng

As Agentic AI gain mainstream adoption, the industry invests heavily in model capabilities, achieving rapid leaps in reasoning and quality. However, these systems remain largely confined to data silos, and each new integration requires…

Cryptography and Security · Computer Science 2025-05-20 Sonu Kumar , Anubhav Girdhar , Ritesh Patil , Divyansh Tripathi

In the artificial intelligence space, as we transition from isolated large language models to autonomous agents capable of complex reasoning and tool use. While foundational architectures and local context management protocols have been…

Multiagent Systems · Computer Science 2026-02-18 Naveen Kumar Krishnan

The Model Context Protocol (MCP) aims to create a standard for how Large Language Models use tools. However, most current research focuses on selecting tools from an existing pool. A more fundamental, yet largely overlooked, problem is how…

Software Engineering · Computer Science 2026-02-12 Chaoqian Ouyang , Ling Yue , Shimin Di , Libin Zheng , Linan Yue , Shaowu Pan , Jian Yin , Min-Ling Zhang

Tool calling has emerged as a critical capability for AI agents. In contrast to conventional tool calling frameworks that rely on static, provider-specific tool definitions, the Model Context Protocol (MCP) offers a unified interface to…

Large language models hold considerable promise for supporting forensic investigations, but their widespread adoption is hindered by a lack of transparency, explainability, and reproducibility. This paper explores how the emerging Model…

Cryptography and Security · Computer Science 2025-06-03 Jan-Niclas Hilgert , Carlo Jakobs , Michael Külper , Martin Lambertz , Axel Mahr , Elmar Padilla

Large Language Models (LLMs) are increasingly integrated into real-world applications via the Model Context Protocol (MCP), a universal open standard for connecting AI agents with data sources and external tools. While MCP enhances the…

Cryptography and Security · Computer Science 2026-02-13 Yixuan Yang , Cuifeng Gao , Daoyuan Wu , Yufan Chen , Yingjiu Li , Shuai Wang

The Model Context Protocol (MCP) has emerged as a standard for connecting large language models (LLMs) with external tools. However, this MCP ecosystem introduces new security risks across hosts, servers, and registries. In this paper, we…

Cryptography and Security · Computer Science 2026-04-29 Xiaofan Li , Xing Gao

The Model Context Protocol (MCP) replaces static, developer-controlled API integrations with more dynamic, user-driven agent systems, which also introduces new security risks. As MCP adoption grows across community servers and major…

Cryptography and Security · Computer Science 2025-11-27 Herman Errico , Jiquan Ngiam , Shanita Sojan

Large Language Models (LLMs) are increasingly augmented with external tools through standardized interfaces like the Model Context Protocol (MCP). However, current MCP implementations face critical limitations: they typically require local…

Cryptography and Security · Computer Science 2026-03-11 Arash Ahmadi , Sarah Sharif , Yaser M. Banad

Bioinformatics web servers are critical resources in modern biomedical research, facilitating interactive exploration of datasets through custom-built interfaces with rich visualization capabilities. However, this human-centric design…

Other Quantitative Biology · Quantitative Biology 2026-02-25 Matthias Flotho , Ian Ferenc Diks , Philipp Flotho , Leidy-Alejandra G. Molano , Pascal Hirsch , Andreas Keller

Large Language Models (LLMs) increasingly rely on external tools to perform complex, realistic tasks, yet their ability to utilize the rapidly expanding Model Contextual Protocol (MCP) ecosystem remains limited. Existing MCP research covers…

Artificial Intelligence · Computer Science 2026-04-17 Wenhao Wang , Peizhi Niu , Zhao Xu , Zhaoyu Chen , Jian Du , Yaxin Du , Xianghe Pang , Keduan Huang , Yanfeng Wang , Qiang Yan , Siheng Chen

The MCP Solver bridges Large Language Models (LLMs) with symbolic solvers through the Model Context Protocol (MCP), an open-source standard for AI system integration. Providing LLMs access to formal solving and reasoning capabilities…

Artificial Intelligence · Computer Science 2025-04-08 Stefan Szeider

Configuring computational fluid dynamics (CFD) simulations requires significant expertise in physics modeling and numerical methods, posing a barrier to non-specialists. Although automating scientific tasks with large language models (LLMs)…

Software Engineering · Computer Science 2025-12-10 Zhehao Dong , Shanghai Du , Zhen Lu , Yue Yang

The increased adoption of the Model Context Protocol (MCP) for AI Agents necessitates robust security for Enterprise integrations. This paper introduces the MCP Gateway to simplify self-hosted MCP server integration. The proposed…

Cryptography and Security · Computer Science 2025-04-29 Ivo Brett

This paper provides an in-depth technical analysis and implementation methodology of the open-source Agent-to-Agent (A2A) protocol developed by Google and the Model Context Protocol (MCP) introduced by Anthropic. While the evolution of…

Artificial Intelligence · Computer Science 2025-10-03 Cheonsu Jeong

The Model Context Protocol (MCP) has unified the interface between Large Language Models (LLMs) and external tools, yet a fundamental gap remains in how agents conceptualize the environments within which they operate. Current paradigms are…

Artificial Intelligence · Computer Science 2026-05-12 Giridhar Ganapavarapu , Dhaval Patel