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Low-dose chest computed tomography (LDCT) captures pulmonary and cardiac structures in a single scan, enabling joint assessment of lung and cardiovascular health. Existing approaches typically model these domains independently and do not…

Computer Vision and Pattern Recognition · Computer Science 2026-05-27 Yifei Zhang , Jiashuo Zhang , Mojtaba Safari , Xiaofeng Yang , Liang Zhao

Confounding is a significant obstacle to unbiased estimation of causal effects from observational data. For settings with high-dimensional covariates -- such as text data, genomics, or the behavioral social sciences -- researchers have…

Artificial Intelligence · Computer Science 2024-02-01 Katherine A. Keith , Sergey Feldman , David Jurgens , Jonathan Bragg , Rohit Bhattacharya

Existing weakly supervised sound event detection (WSSED) work has not explored both types of co-occurrences simultaneously, i.e., some sound events often co-occur, and their occurrences are usually accompanied by specific background sounds,…

Sound · Computer Science 2023-03-13 Yifei Xin , Dongchao Yang , Fan Cui , Yujun Wang , Yuexian Zou

We propose a new complex block floating-point format to reduce implementation complexity. The new format achieves wordlength reduction by sharing an exponent across the block of samples, and uses box encoding for the shared exponent to…

Information Theory · Computer Science 2017-10-26 Yeong Foong Choo , Brian L. Evans , Alan Gatherer

Survival prediction aims to evaluate the risk level of cancer patients. Existing methods primarily rely on pathology and genomics data, either individually or in combination. From the perspective of cancer pathogenesis, epigenetic changes,…

Machine Learning · Computer Science 2025-06-23 Haipeng Zhou , Sicheng Yang , Sihan Yang , Jing Qin , Lei Chen , Lei Zhu

The conditional average treatment effect (CATE) is the best measure of individual causal effects given baseline covariates. However, the CATE only captures the (conditional) average, and can overlook risks and tail events, which are…

Machine Learning · Statistics 2025-06-05 Nathan Kallus , Miruna Oprescu

Composite endpoints consisting of both terminal and non-terminal events, such as death and hospitalization, are frequently used in cardiovascular clinical trials. The Finkelstein-Schoenfeld (FS) test provides a way to employ a hierarchical…

Methodology · Statistics 2026-03-03 Yunhan Mou , Tassos Kyriakides , Scott Hummel , Fan Li , Yuan Huang

We derive computational formulas for the generalized Choquet integral based on the novel survival function introduced by M. Boczek et al. [1]. We demonstrate its usefulness on the Knapsack problem and the problem of accommodation options.…

Optimization and Control · Mathematics 2023-06-23 Stanislav Basarik , Jana Borzová , Lenka Halčinová , Jaroslav Šupina

Clinical trials are essential to drug development but time-consuming, costly, and prone to failure. Accurate trial outcome prediction based on historical trial data promises better trial investment decisions and more trial success. Existing…

Machine Learning · Computer Science 2023-04-12 Zifeng Wang , Cao Xiao , Jimeng Sun

In this study, we focus on estimating the heterogeneous treatment effect (HTE) for survival outcome. The outcome is subject to censoring and the number of covariates is high-dimensional. We utilize data from both the randomized controlled…

Methodology · Statistics 2025-03-21 Xin Ye , Shu Yang , Xiaofei Wang , Yanyan Liu

One of the most common ways researchers compare survival outcomes across treatments when confounding is present is using Cox regression. This model is limited by its underlying assumption of proportional hazards; in some cases, substantial…

Applications · Statistics 2021-02-02 Elizabeth A. Handorf , Marc Smaldone , Sujana Movva , Nandita Mitra

Unsupervised learning can leverage large-scale data sources without the need for annotations. In this context, deep learning-based auto encoders have shown great potential in detecting anomalies in medical images. However, state-of-the-art…

Machine Learning · Computer Science 2018-12-17 David Zimmerer , Simon A. A. Kohl , Jens Petersen , Fabian Isensee , Klaus H. Maier-Hein

Assessing disease severity with ordinal classes, where each class reflects increasing severity levels, benefits from loss functions designed for this ordinal structure. Traditional categorical loss functions, like Cross-Entropy (CE), often…

Computer Vision and Pattern Recognition · Computer Science 2025-01-14 Gorkem Polat , Ümit Mert Çağlar , Alptekin Temizel

Integrating methods for time-to-event prediction with diagnostic imaging modalities is of considerable interest, as accurate estimates of survival requires accounting for censoring of individuals within the observation period. New methods…

Observational epidemiological studies commonly seek to estimate the causal effect of an exposure on an outcome. Adjustment for potential confounding bias in modern studies is challenging due to the presence of high-dimensional confounding,…

Methodology · Statistics 2025-08-29 Susan Ellul , Stijn Vansteelandt , John B. Carlin , Margarita Moreno-Betancur

Treatment effect estimation involves assessing the impact of different treatments on individual outcomes. Current methods estimate Conditional Average Treatment Effect (CATE) using observational datasets where covariates are collected…

Machine Learning · Computer Science 2025-02-10 Lokesh Nagalapatti , Pranava Singhal , Avishek Ghosh , Sunita Sarawagi

Matrix-covariate is now frequently encountered in many biomedical researches. It is common to fit conventional statistical models by vectorizing matrix-covariate. This strategy, however, results in a large number of parameters, while the…

Applications · Statistics 2016-07-12 Hung Hung , Zhi-Yu Jou

Continual Event Detection (CED) poses a formidable challenge due to the catastrophic forgetting phenomenon, where learning new tasks (with new coming event types) hampers performance on previous ones. In this paper, we introduce a novel…

Computation and Language · Computer Science 2024-10-14 Viet Dao , Van-Cuong Pham , Quyen Tran , Thanh-Thien Le , Linh Ngo Van , Thien Huu Nguyen

Medical imaging foundation models must adapt over time, yet full retraining is often blocked by privacy constraints and cost. We present a continual learning framework that avoids storing patient exemplars by pairing class conditional…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Anoushka Harit , William Prew , Zhongtian Sun , Florian Markowetz

Established image recovery methods in fast ultrasound imaging, e.g. delay-and-sum, trade the image quality for the high frame rate. Cutting-edge inverse scattering methods based on compressed sensing (CS) disrupt this tradeoff via a priori…

Medical Physics · Physics 2019-03-15 Martin F. Schiffner
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