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We propose a generalized focal loss function based on the Tversky index to address the issue of data imbalance in medical image segmentation. Compared to the commonly used Dice loss, our loss function achieves a better trade off between…

Brain lesion segmentation from multi-modal MRI often assumes fixed modality sets or predefined pathologies, making existing models difficult to adapt across cohorts and imaging protocols. Continual learning (CL) offers a natural solution…

Accurate segmentation of Optical Coherence Tomography (OCT) images is crucial for diagnosing and monitoring retinal diseases. However, the labor-intensive nature of pixel-level annotation limits the scalability of supervised learning for…

Several supermodular losses have been shown to improve the perceptual quality of image segmentation in a discriminative framework such as a structured output support vector machine (SVM). These loss functions do not necessarily have the…

The segmentation of substantial brain lesions is a significant and challenging task in the field of medical image segmentation. Substantial brain lesions in brain imaging exhibit high heterogeneity, with indistinct boundaries between lesion…

Semi-supervised learning has the potential to improve the data-efficiency of training data-hungry deep neural networks, which is especially important for medical image analysis tasks where labeled data is scarce. In this work, we present a…

Medical image segmentation is undergoing a paradigm shift from conventional visual pattern matching to cognitive reasoning analysis. Although Multimodal Large Language Models (MLLMs) have shown promise in integrating linguistic and visual…

Inter-scanner variability of magnetic resonance imaging has an adverse impact on the diagnostic and prognostic quality of the scans and necessitates the development of models robust to domain shift inflicted by the unseen scanner data.…

Automated segmentation of multiple sclerosis (MS) lesions using multicontrast magnetic resonance (MR) images improves efficiency and reproducibility compared to manual delineation, with deep learning (DL) methods achieving state-of-the-art…

Biomedical image segmentation plays a significant role in computer-aided diagnosis. However, existing CNN based methods rely heavily on massive manual annotations, which are very expensive and require huge human resources. In this work, we…

Lesion segmentation on computed tomography (CT) scans is an important step for precisely monitoring changes in lesion/tumor growth. This task, however, is very challenging since manual segmentation is prohibitively time-consuming,…

Accurate segmentation of brain vessels is crucial for cerebrovascular disease diagnosis and treatment. However, existing methods face challenges in capturing small vessels and handling datasets that are partially or ambiguously annotated.…

Cortical lesions (CLs) have emerged as valuable biomarkers in multiple sclerosis (MS), offering high diagnostic specificity and prognostic relevance. However, their routine clinical integration remains limited due to subtle magnetic…

Medical image segmentation, or computing voxelwise semantic masks, is a fundamental yet challenging task to compute a voxel-level semantic mask. To increase the ability of encoder-decoder neural networks to perform this task across large…

Medical image segmentation has achieved remarkable advancements using deep neural networks (DNNs). However, DNNs often need big amounts of data and annotations for training, both of which can be difficult and costly to obtain. In this work,…

Lumbar Spinal Stenosis (LSS) diagnosis remains a critical clinical challenge, with diagnosis heavily dependent on labor-intensive manual interpretation of multi-view Magnetic Resonance Imaging (MRI), leading to substantial inter-observer…

3D medical image segmentation has progressed considerably due to Convolutional Neural Networks (CNNs) and Vision Transformers (ViTs), yet these methods struggle to balance long-range dependency acquisition with computational efficiency. To…

Unpaired Multi-Modal Learning (UMML) which leverages unpaired multi-modal data to boost model performance on each individual modality has attracted a lot of research interests in medical image analysis. However, existing UMML methods…

Despite the remarkable performance of supervised medical image segmentation models, relying on a large amount of labeled data is impractical in real-world situations. Semi-supervised learning approaches aim to alleviate this challenge using…

We present a method combining affinity prediction with region agglomeration, which improves significantly upon the state of the art of neuron segmentation from electron microscopy (EM) in accuracy and scalability. Our method consists of a…