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Model-driven analysis of biophysical phenomena is gaining increased attention and utility for medical imaging applications. In magnetic resonance imaging (MRI), the availability of well-established models for describing the relations…

Medical Physics · Physics 2023-10-31 Dinor Nagar , Nikita Vladimirov , Christian T. Farrar , Or Perlman

The deformation of the lateral ventricle (LV) shape is widely studied to identify specific morphometric changes associated with diseases. Since LV enlargement is considered a relative change due to brain atrophy, local longitudinal LV…

Image and Video Processing · Electrical Eng. & Systems 2024-10-10 Wonjung Park , Suhyun Ahn , Jinah Park

Functional magnetic resonance imaging (fMRI) time series are known to exhibit long-range temporal dependencies that challenge traditional modeling approaches. In this study, we propose a novel computational pipeline to characterize and…

Applications · Statistics 2025-08-19 Yasaman Shahhosseini , Cédric Beaulac , Farouk S. Nathoo , Michelle F. Miranda

Accurate longitudinal analysis of brain MRI is often hindered by evolving lesions, which bias automated neuroimaging pipelines. While deep generative models have shown promise in inpainting these lesions, most existing methods operate…

Image and Video Processing · Electrical Eng. & Systems 2026-03-09 Zahra Karimaghaloo , Dumitru Fetco , Haz-Edine Assemlal , Hassan Rivaz , Douglas L. Arnold

This paper addresses the morphing of manifold-valued images based on the time discrete geodesic paths model of Berkels, Effland and Rumpf 2015. Although for our manifold-valued setting such an interpretation of the energy functional is not…

Numerical Analysis · Mathematics 2018-05-09 Sebastian Neumayer , Johannes Persch , Gabriele Steidl

While current research has shown the importance of Multi-parametric MRI (mpMRI) in diagnosing prostate cancer (PCa), further investigation is needed for how to incorporate the specific structures of the mpMRI data, such as the regional…

Machine Learning · Statistics 2021-11-04 Jin Jin , Lin Zhang , Ethan Leng , Gregory J. Metzger , Joseph S. Koopmeiners

We extend the Locally-Subdivided Neural Intersection Function (LSNIF) to support parameterized deformable and animated geometry. Our approach introduces a rest-space and deformed-space formulation inspired by meshless rendering, allowing…

Graphics · Computer Science 2026-04-28 Chih-Chen Kao , Grzegorz Makowski , Shin Fujieda , Takahiro Harada

We introduce an unsupervised deep manifold learning algorithm for motion-compensated dynamic MRI. We assume that the motion fields in a free-breathing lung MRI dataset live on a manifold. The motion field at each time instant is modeled as…

Image and Video Processing · Electrical Eng. & Systems 2021-11-23 Qing Zou , Luis A. Torres , Sean B. Fain , Mathews Jacob

Extracting compact, physically interpretable representations from high-dimensional scientific data is a persistent challenge due to the complex, nonlinear structures inherent in physical systems. We propose a Gaussian Mixture Variational…

Machine Learning · Computer Science 2025-12-01 Tiffany Fan , Murray Cutforth , Marta D'Elia , Alexandre Cortiella , Alireza Doostan , Eric Darve

Energy-based models (EBMs) are a simple yet powerful framework for generative modeling. They are based on a trainable energy function which defines an associated Gibbs measure, and they can be trained and sampled from via well-established…

Machine Learning · Computer Science 2021-05-06 Carles Domingo-Enrich , Alberto Bietti , Eric Vanden-Eijnden , Joan Bruna

Energy landscapes provide a valuable means for studying the folding dynamics of short RNA molecules in detail by modeling all possible structures and their transitions. Higher abstraction levels based on a macro-state decomposition of the…

Biomolecules · Quantitative Biology 2014-09-09 Martin Mann , Marcel Kucharik , Christoph Flamm , Michael T. Wolfinger

When considering functional principal component analysis for sparsely observed longitudinal data that take values on a nonlinear manifold, a major challenge is how to handle the sparse and irregular observations that are commonly…

Methodology · Statistics 2018-12-13 Xiongtao Dai , Zhenhua Lin , Hans-Georg Müller

Free-breathing cardiac MRI schemes are emerging as competitive alternatives to breath-held cine MRI protocols, enabling applicability to pediatric and other population groups that cannot hold their breath. Because the data from the slices…

Image and Video Processing · Electrical Eng. & Systems 2021-11-23 Qing Zou , Abdul Haseeb Ahmed , Prashant Nagpal , Sarv Priya , Rolf F Schulte , Mathews Jacob

We develop Riemannian approaches to variational autoencoders (VAEs) for PDE-type ambient data with regularizing geometric latent dynamics, which we refer to as VAE-DLM, or VAEs with dynamical latent manifolds. We redevelop the VAE framework…

Machine Learning · Computer Science 2026-01-21 Andrew Gracyk

As exposure to electromagnetic waves becomes increasingly widespread, it is important to quantify how incident fields couple into biological tissue and where absorbed energy is deposited. This work presents an analytical, physics based…

Biological Physics · Physics 2026-04-09 Hongyun Wang , Shannon E. Foley , Hong Zhou

Radio-frequency dosimetry is an important process in human safety and for compliance of related products. Recently, computational human models generated from medical images have often been used for such assessment, especially to consider…

Machine Learning · Computer Science 2020-04-29 Essam A. Rashed , Yinliang Diao , Akimasa Hirata

Magnetic Resonance Imaging (MRI) is indispensable in clinical practice but remains constrained by fragmented, multi-stage workflows encompassing acquisition, reconstruction, segmentation, detection, diagnosis, and reporting. While deep…

Computer Vision and Pattern Recognition · Computer Science 2025-08-26 Xingxin He , Aurora Rofena , Ruimin Feng , Haozhe Liao , Zhaoye Zhou , Albert Jang , Fang Liu

Latent space Energy-Based Models (EBMs), also known as energy-based priors, have drawn growing interests in generative modeling. Fueled by its flexibility in the formulation and strong modeling power of the latent space, recent works built…

Machine Learning · Computer Science 2023-10-06 Peiyu Yu , Sirui Xie , Xiaojian Ma , Baoxiong Jia , Bo Pang , Ruiqi Gao , Yixin Zhu , Song-Chun Zhu , Ying Nian Wu

Guided wave-based structural health monitoring (SHM) remains a powerful strategy for identifying early-stage defects and safeguarding vital aerospace structures. Yet, its practical use is often hindered by the enormous, high-dimensional…

Signal Processing · Electrical Eng. & Systems 2025-04-16 Yiming Fan , Dimitris G Giovanis , Fotis Kopsaftopoulos

The elasticity of soft tissues has been widely considered as a characteristic property to differentiate between healthy and vicious tissues and, therefore, motivated several elasticity imaging modalities, such as Ultrasound Elastography,…

Image and Video Processing · Electrical Eng. & Systems 2022-05-30 Weiguo Cao , Marc J. Pomeroy , Zhengrong Liang , Yongfeng Gao , Yongyi Shi , Jiaxing Tan , Fangfang Han , Jing Wang , Jianhua Ma , Hongbin Lu , Almas F. Abbasi , Perry J. Pickhardt