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Pre-training has shown success in different areas of machine learning, such as Computer Vision, Natural Language Processing (NLP), and medical imaging. However, it has not been fully explored for clinical data analysis. An immense amount of…

Machine Learning · Computer Science 2023-07-18 Chantal Pellegrini , Nassir Navab , Anees Kazi

Foundation Models (FMs) serve as a general class for the development of artificial intelligence systems, offering broad potential for generalization across a spectrum of downstream tasks. Despite extensive research into self-supervised…

Machine Learning · Computer Science 2024-06-17 Yuhao Xu , Xinqi Liu , Keyu Duan , Yi Fang , Yu-Neng Chuang , Daochen Zha , Qiaoyu Tan

To make sense of their surroundings, intelligent systems must transform complex sensory inputs to structured codes that are reduced to task-relevant information such as object category. Biological agents achieve this in a largely autonomous…

Computer Vision and Pattern Recognition · Computer Science 2024-07-09 Robin Weiler , Matthias Brucklacher , Cyriel M. A. Pennartz , Sander M. Bohté

Large Reasoning Models (LRMs) have demonstrated strong capabilities in complex multi-step reasoning, opening new opportunities for automating optimization modeling. However, existing domain adaptation methods, originally designed for…

Computation and Language · Computer Science 2025-10-07 Zhengyang Tang , Zihan Ye , Chenyu Huang , Xuhan Huang , Chengpeng Li , Sihang Li , Guanhua Chen , Ming Yan , Zizhuo Wang , Hongyuan Zha , Dayiheng Liu , Benyou Wang

Natural products, as metabolites from microorganisms, animals, or plants, exhibit diverse biological activities, making them crucial for drug discovery. Nowadays, existing deep learning methods for natural products research primarily rely…

Quantitative Methods · Quantitative Biology 2026-05-11 Yuheng Ding , Bo Qiang , Shaoning Li , Yiran Zhou , Jie Yu , Qi Li , Cheng Shi , Liangren Zhang , Yusong Wang , Nanning Zheng , Zhenming Liu

Pixel-level vision tasks, such as semantic segmentation, require extensive and high-quality annotated data, which is costly to obtain. Semi-supervised semantic segmentation (SSSS) has emerged as a solution to alleviate the labeling burden…

Computer Vision and Pattern Recognition · Computer Science 2025-07-22 Danhui Chen , Ziquan Liu , Chuxi Yang , Dan Wang , Yan Yan , Yi Xu , Xiangyang Ji

Cultural awareness in language models is the capacity to understand and adapt to diverse cultural contexts. However, most existing approaches treat culture as static background knowledge, overlooking its dynamic and evolving nature. This…

Computation and Language · Computer Science 2026-01-08 Lingzhi Shen , Xiaohao Cai , Yunfei Long , Imran Razzak , Guanming Chen , Shoaib Jameel

A foundation model like GPT elicits many emergent abilities, owing to the pre-training with broad inclusion of data and the use of the powerful Transformer architecture. While foundation models in natural languages are prevalent, can we…

Machine Learning · Computer Science 2025-06-18 Ziyuan Tang , Jie Chen

Large pretrained visual foundation models exhibit impressive general capabilities. However, the extensive prior knowledge inherent in these models can sometimes be a double-edged sword when adapting them to downstream tasks in specific…

Computer Vision and Pattern Recognition · Computer Science 2025-03-24 Qinghe Ma , Jian Zhang , Zekun Li , Lei Qi , Qian Yu , Yinghuan Shi

Quantification of behavior is critical in applications ranging from neuroscience, veterinary medicine and animal conservation efforts. A common key step for behavioral analysis is first extracting relevant keypoints on animals, known as…

Computer Vision and Pattern Recognition · Computer Science 2025-04-22 Shaokai Ye , Anastasiia Filippova , Jessy Lauer , Steffen Schneider , Maxime Vidal , Tian Qiu , Alexander Mathis , Mackenzie Weygandt Mathis

Artificial intelligence and machine learning have shown great promise in their ability to accelerate novel materials discovery. As researchers and domain scientists seek to unify and consolidate chemical knowledge, the case for models with…

Model merging aims to integrate the strengths of multiple fine-tuned models into a unified model while preserving task-specific capabilities. Existing methods, represented by task arithmetic, are typically classified into global- and…

Machine Learning · Computer Science 2025-06-17 Kunda Yan , Min Zhang , Sen Cui , Zikun Qu , Bo Jiang , Feng Liu , Changshui Zhang

Humans and animals have a rich and flexible understanding of the physical world, which enables them to infer the underlying dynamical trajectories of objects and events, plausible future states, and use that to plan and anticipate the…

Artificial Intelligence · Computer Science 2023-10-26 Aran Nayebi , Rishi Rajalingham , Mehrdad Jazayeri , Guangyu Robert Yang

Self-supervised pre-training paradigms have been extensively explored in the field of skeleton-based action recognition. In particular, methods based on masked prediction have pushed the performance of pre-training to a new height. However,…

Computer Vision and Pattern Recognition · Computer Science 2024-01-03 Ruizhuo Xu , Linzhi Huang , Mei Wang , Jiani Hu , Weihong Deng

Foundation models, especially those using transformers as backbones, have gained significant popularity, particularly in language and language-vision tasks. However, large foundation models are typically trained on high-quality data, which…

Signal Processing · Electrical Eng. & Systems 2024-04-30 Cheng Ding , Zhicheng Guo , Zhaoliang Chen , Randall J Lee , Cynthia Rudin , Xiao Hu

Real-time decoding of neural activity is central to neuroscience and neurotechnology applications, from closed-loop experiments to brain-computer interfaces, where models are subject to strict latency constraints. Traditional methods,…

Neurons and Cognition · Quantitative Biology 2025-11-10 Avery Hee-Woon Ryoo , Nanda H. Krishna , Ximeng Mao , Mehdi Azabou , Eva L. Dyer , Matthew G. Perich , Guillaume Lajoie

Research in many fields has shown that transfer learning (TL) is well-suited to improve the performance of deep learning (DL) models in datasets with small numbers of samples. This empirical success has triggered interest in the application…

Neurons and Cognition · Quantitative Biology 2021-11-03 Armin W. Thomas , Ulman Lindenberger , Wojciech Samek , Klaus-Robert Müller

In this work we introduce a self-supervised pretraining framework for transformers on functional Magnetic Resonance Imaging (fMRI) data. First, we pretrain our architecture on two self-supervised tasks simultaneously to teach the model a…

Machine Learning · Computer Science 2023-05-17 Sean Paulsen , Michael Casey

Pretraining DNA language models (DNALMs) on the full human genome is resource-intensive, yet often considered necessary for strong downstream performance. Inspired by recent findings in NLP and long-context modeling, we explore an…

Genomics · Quantitative Biology 2025-06-24 Sohan Mupparapu , Parameswari Krishnamurthy , Ratish Puduppully

We introduce Correlational Image Modeling (CIM), a novel and surprisingly effective approach to self-supervised visual pre-training. Our CIM performs a simple pretext task: we randomly crop image regions (exemplars) from an input image…

Computer Vision and Pattern Recognition · Computer Science 2023-03-31 Wei Li , Jiahao Xie , Chen Change Loy