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Calcium imaging is an important technique for monitoring the activity of thousands of neurons simultaneously. As calcium imaging datasets grow in size, automated detection of individual neurons is becoming important. Here we apply a…

Neurons and Cognition · Quantitative Biology 2016-12-23 Noah J. Apthorpe , Alexander J. Riordan , Rob E. Aguilar , Jan Homann , Yi Gu , David W. Tank , H. Sebastian Seung

Calcium imaging is a critical tool for measuring the activity of large neural populations. Much effort has been devoted to developing "pre-processing" tools for calcium video data, addressing the important issues of e.g., motion correction,…

Neurons and Cognition · Quantitative Biology 2020-06-09 Xue-Xin Wei , Ding Zhou , Andres Grosmark , Zaki Ajabi , Fraser Sparks , Pengcheng Zhou , Mark Brandon , Attila Losonczy , Liam Paninski

With the increasing popularity of calcium imaging data in neuroscience research, methods for analyzing calcium trace data are critical to address various questions. The observed calcium traces are either analyzed directly or deconvolved to…

Neurons and Cognition · Quantitative Biology 2021-03-04 Tong Shen , Gyorgy Lur , Xiangmin Xu , Zhaoxia Yu

Recent advances in clinical AI have enabled remarkable progress across many clinical domains. However, existing benchmarks and models are primarily limited to a small set of modalities and tasks, which hinders the development of large-scale…

Machine Learning · Computer Science 2025-03-21 Wei Dai , Peilin Chen , Malinda Lu , Daniel Li , Haowen Wei , Hejie Cui , Paul Pu Liang

We present a new model for the dynamics of the presynaptic intracellular calcium concentration in neurons evoked by various stimulation protocols. The aim of the model is twofold: We want to discuss the calcium transients during and after…

Biological Physics · Physics 2007-05-23 Michael Meyer-Hermann , Frido Erler , Gerhard Soff

Machine learning approaches have become popular for molecular modeling tasks, including molecular force fields and properties prediction. Traditional supervised learning methods suffer from scarcity of labeled data for particular tasks,…

Chemical Physics · Physics 2022-11-29 Xiang Gao , Weihao Gao , Wenzhi Xiao , Zhirui Wang , Chong Wang , Liang Xiang

A reliable foundation model of functional neuroimages is critical to promote clinical applications where the performance of current AI models is significantly impeded by a limited sample size. To that end, tremendous efforts have been made…

Machine Learning · Computer Science 2025-10-23 Ziquan Wei , Tingting Dan , Guorong Wu

User modeling is critical for many personalized web services. Many existing methods model users based on their behaviors and the labeled data of target tasks. However, these methods cannot exploit useful information in unlabeled user…

Information Retrieval · Computer Science 2020-10-06 Chuhan Wu , Fangzhao Wu , Tao Qi , Jianxun Lian , Yongfeng Huang , Xing Xie

Predicting future neural activity is a core challenge in modeling brain dynamics, with applications ranging from scientific investigation to closed-loop neurotechnology. While recent models of population activity emphasize interpretability…

Neurons and Cognition · Quantitative Biology 2026-02-11 Yu Duan , Hamza Tahir Chaudhry , Misha B. Ahrens , Christopher D Harvey , Matthew G Perich , Karl Deisseroth , Kanaka Rajan

Recent progress in self-supervision shows that pre-training large neural networks on vast amounts of unsupervised data can lead to impressive increases in generalisation for downstream tasks. Such models, recently coined as foundation…

Content-based collaborative filtering (CCF) predicts user-item interactions based on both users' interaction history and items' content information. Recently, pre-trained language models (PLM) have been used to extract high-quality item…

Computation and Language · Computer Science 2022-11-23 Yoonseok Yang , Kyu Seok Kim , Minsam Kim , Juneyoung Park

Supervised deep learning models for automated CTG analysis are typically constrained by narrowly curated labelled datasets and limited patient cohorts, leaving substantial volumes of physiologically informative clinical recordings untapped.…

Machine Learning · Computer Science 2026-05-06 Sheng Wong , Ravi Shankar , Beth Albert , Hao Fei , Lin Li , Imane Ben M'Barek , Manu Vatish , Gabriel Davis Jones

Recent advances in Transformer-based large language models (LLMs) have led to significant performance improvements across many tasks. These gains come with a drastic increase in the models' size, potentially leading to slow and costly use…

Computation and Language · Computer Science 2022-10-26 Tal Schuster , Adam Fisch , Jai Gupta , Mostafa Dehghani , Dara Bahri , Vinh Q. Tran , Yi Tay , Donald Metzler

As language models (LMs) become increasingly powerful and widely used, it is important to quantify them for sociodemographic bias with potential for harm. Prior measures of bias are sensitive to perturbations in the templates designed to…

Computation and Language · Computer Science 2024-08-09 Vipul Gupta , Pranav Narayanan Venkit , Hugo Laurençon , Shomir Wilson , Rebecca J. Passonneau

Pre-trained machine learning (ML) models have shown great performance for a wide range of applications, in particular in natural language processing (NLP) and computer vision (CV). Here, we study how pre-training could be used for…

Machine Learning · Computer Science 2024-01-05 Shashank Subramanian , Peter Harrington , Kurt Keutzer , Wahid Bhimji , Dmitriy Morozov , Michael Mahoney , Amir Gholami

Deriving multimodal representations of audio and lexical inputs is a central problem in Natural Language Understanding (NLU). In this paper, we present Contrastive Aligned Audio-Language Multirate and Multimodal Representations (CALM), an…

Audio and Speech Processing · Electrical Eng. & Systems 2022-02-09 Vin Sachidananda , Shao-Yen Tseng , Erik Marchi , Sachin Kajarekar , Panayiotis Georgiou

Foundational models with billions of parameters which have been trained on large corpora of data have demonstrated non-trivial skills in a variety of domains. However, due to their monolithic structure, it is challenging and expensive to…

Over the past decade, Time Series Classification (TSC) has gained an increasing attention. While various methods were explored, deep learning - particularly through Convolutional Neural Networks (CNNs)-stands out as an effective approach.…

Machine Learning · Computer Science 2024-02-29 Ali Ismail-Fawaz , Maxime Devanne , Stefano Berretti , Jonathan Weber , Germain Forestier

The brain can only be fully understood through the lens of the behavior it generates -- a guiding principle in modern neuroscience research that nevertheless presents significant technical challenges. Many studies capture behavior with…

Neurons and Cognition · Quantitative Biology 2026-03-02 Yanchen Wang , Han Yu , Ari Blau , Yizi Zhang , The International Brain Laboratory , Liam Paninski , Cole Hurwitz , Matt Whiteway

Foundational models (FMs), pretrained on extensive datasets using self-supervised techniques, are capable of learning generalized patterns from large amounts of data. This reduces the need for extensive labeled datasets for each new task,…

Machine Learning · Computer Science 2024-06-19 Quan M. Tran , Suong N. Hoang , Lam M. Nguyen , Dzung Phan , Hoang Thanh Lam