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Variable selection methods are required in practical statistical modeling, to identify and include only the most relevant predictors, and then improving model interpretability. Such variable selection methods are typically employed in…

Univariate regression models have rich literature for counting data. However, this is not the case for multivariate count data. Therefore, we present the Multivariate Generalized Linear Mixed Models framework that deals with a multivariate…

Gene regulatory network inference is crucial for understanding the complex molecular interactions in various genetic and environmental conditions. The rapid development of single-cell RNA sequencing (scRNA-seq) technologies unprecedentedly…

Methodology · Statistics 2021-11-09 Feiyi Xiao , Junjie Tang , Huaying Fang , Ruibin Xi

Multivariate count data are commonly encountered through high-throughput sequencing technologies in bioinformatics, text mining, or in sports analytics. Although the Poisson distribution seems a natural fit to these count data, its…

Computation · Statistics 2020-04-16 Sanjeena Subedi , Ryan Browne

In applications such as gene regulatory network analysis based on single-cell RNA sequencing data, samples often come from a mixture of different populations and each population has its own unique network. Available graphical models often…

Methodology · Statistics 2022-12-08 Junjie Tang , Changhu Wang , Feiyi Xiao , Ruibin Xi

Modeling data with multivariate count responses is a challenging problem due to the discrete nature of the responses. Existing methods for univariate count responses cannot be easily extended to the multivariate case since the dependency…

Methodology · Statistics 2016-08-15 Hao Wu , Xinwei Deng , Naren Ramakrishnan

In this paper we consider Poisson loglinear models with linear constraints (LMLC) on the expected table counts. Multinomial and product multinomial loglinear models can be obtained by considering that some marginal totals (linear…

Statistics Theory · Mathematics 2014-03-26 Nirian Martin , Leandro Pardo

When studying ecosystems, hierarchical trees are often used to organize entities based on proximity criteria, such as the taxonomy in microbiology, social classes in geography, or product types in retail businesses, offering valuable…

Methodology · Statistics 2025-06-27 Alexandre Chaussard , Anna Bonnet , Elisabeth Gassiat , Sylvain Le Corff

Count data analysis is essential across diverse fields, from ecology and accident analysis to single-cell RNA sequencing (scRNA-seq) and metagenomics. While log transformations are computationally efficient, model-based approaches such as…

Methodology · Statistics 2024-11-14 Bastien Batardière , Julien Chiquet , Mahendra Mariadassou

In multivariate statistics, the question of finding direct interactions can be formulated as a problem of network inference - or network reconstruction - for which the Gaussian graphical model (GGM) provides a canonical framework.…

Methodology · Statistics 2018-06-11 Julien Chiquet , Mahendra Mariadassou , Stéphane Robin

Count data are ubiquitous in ecology and the Poisson generalized linear model (GLM) is commonly used to model the association between counts and explanatory variables of interest. When fitting this model to the data, one typically proceeds…

Methodology · Statistics 2020-07-14 Harlan Campbell

Modeling count data is important in physics and other scientific disciplines, where measurements often involve discrete, non-negative quantities such as photon or neutrino detection events. Traditional parametric approaches can be trained…

Data Analysis, Statistics and Probability · Physics 2026-02-10 Anushka Saha , Abhijith Gandrakota , Alexandre V. Morozov

Researchers are often interested in understanding the relationship between a set of covariates and a set of response variables. To achieve this goal, the use of regression analysis, either linear or generalized linear models, is largely…

The Poisson log-normal model is a latent variable model that provides a generic framework for the analysis of multivariate count data. Inferring its parameters can be a daunting task since the conditional distribution of the latent…

Computation · Statistics 2026-05-19 Julien Stoehr , Stephane S. Robin

Count-weighted temporal networks often exhibit unequal dispersion in the edge weights, which cannot be fully explained by modelling observational heterogeneity through latent factors in the conditional mean. Therefore, we propose new…

Methodology · Statistics 2026-04-15 Giulia Carallo , Roberto Casarin , Antonio Peruzzi

Empirical networks are often globally sparse, with a small average number of connections per node, when compared to the total size of the network. However, this sparsity tends not to be homogeneous, and networks can also be locally dense,…

Physics and Society · Physics 2020-07-20 Tiago P. Peixoto

Poisson regression is a popular tool for modeling count data and is applied in a vast array of applications from the social to the physical sciences and beyond. Real data, however, are often over- or under-dispersed and, thus, not conducive…

Applications · Statistics 2010-11-10 Kimberly F. Sellers , Galit Shmueli

In behavioral and psychiatric research, data consisting of a per-subject proportion of "successes" and "failures" over a finite number of trials often arise. This kind of clustered binary data are usually non-normally distributed, which can…

Quantitative Methods · Quantitative Biology 2016-05-09 Alberto Ferrari , Mario Comelli

Many microbes associate with higher eukaryotes and impact their vitality. In order to engineer microbiomes for host benefit, we must understand the rules of community assembly and maintenence, which in large part, demands an understanding…

Quantitative Methods · Quantitative Biology 2014-12-02 Surojit Biswas , Meredith McDonald , Derek S. Lundberg , Jeffery L. Dangl , Vladimir Jojic

Relational data characterized by directed edges with count measurements are common in social science. Most existing methods either assume the count edges are derived from continuous random variables or model the edge dependency by…

Methodology · Statistics 2025-02-18 Wenqin Du , Bailey K. Fosdick , Wen Zhou
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