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Scientific reasoning, the process through which humans apply logic, evidence, and critical thinking to explore and interpret scientific phenomena, is essential in advancing knowledge reasoning across diverse fields. However, despite…

Computation and Language · Computer Science 2026-04-21 Yibo Yan , Shen Wang , Jiahao Huo , Jingheng Ye , Zhendong Chu , Xuming Hu , Philip S. Yu , Carla Gomes , Bart Selman , Qingsong Wen

We propose RecaLLM, a set of reasoning language models post-trained to make effective use of long-context information. In-context retrieval, which identifies relevant evidence from context, and reasoning are deeply intertwined: retrieval…

Computation and Language · Computer Science 2026-04-13 Kyle Whitecross , Negin Rahimi

Large Language Models (LLMs) have shown remarkable performance on complex reasoning tasks, especially when equipped with long chain-of-thought (CoT) reasoning. However, eliciting long CoT typically requires large-scale reinforcement…

Computation and Language · Computer Science 2026-01-30 Huiyuan Lai , Malvina Nissim

When addressing professional questions in the biomedical domain, humans typically acquire multiple pieces of information as evidence and engage in multifaceted analysis to provide high-quality answers. Current LLM-based question answering…

Computation and Language · Computer Science 2025-09-03 Chang Zong , Jian Wan , Siliang Tang , Lei Zhang

Corpus distillation for biomedical large language models (LLMs) seeks to address the pressing challenge of insufficient quantity and quality in open-source annotated scientific corpora, which remains a bottleneck for effective LLM training…

Computation and Language · Computer Science 2025-12-19 Meng Xiao , Xunxin Cai , Qingqing Long , Chengrui Wang , Yuanchun Zhou , Hengshu Zhu

Open-source Large Language Models (LLMs) and their specialized variants, particularly Code LLMs, have recently delivered impressive performance. However, previous Code LLMs are typically fine-tuned on single-source data with limited quality…

Computation and Language · Computer Science 2025-02-04 Zifan Song , Yudong Wang , Wenwei Zhang , Kuikun Liu , Chengqi Lyu , Demin Song , Qipeng Guo , Hang Yan , Dahua Lin , Kai Chen , Cairong Zhao

Biomedical semantic question answering rooted in information retrieval can play a crucial role in keeping up to date with vast, rapidly evolving and ever-growing biomedical literature. A robust system can help researchers, healthcare…

Information Retrieval · Computer Science 2025-07-09 Shashank Verma , Fengyi Jiang , Xiangning Xue

Large language models (LLMs) have shown remarkable capabilities in general domains, but their application to multi-omics biology remains underexplored. To address this gap, we introduce Biology-Instructions, the first large-scale…

Transferring the reasoning capability from stronger large language models (LLMs) to smaller ones has been quite appealing, as smaller LLMs are more flexible to deploy with less expense. Among the existing solutions, knowledge distillation…

Computation and Language · Computer Science 2024-11-26 Yijun Tian , Yikun Han , Xiusi Chen , Wei Wang , Nitesh V. Chawla

Chemical reasoning usually involves complex, multi-step processes that demand precise calculations, where even minor errors can lead to cascading failures. Furthermore, large language models (LLMs) encounter difficulties handling…

Computation and Language · Computer Science 2025-01-14 Xiangru Tang , Tianyu Hu , Muyang Ye , Yanjun Shao , Xunjian Yin , Siru Ouyang , Wangchunshu Zhou , Pan Lu , Zhuosheng Zhang , Yilun Zhao , Arman Cohan , Mark Gerstein

Multilingual reasoning remains a significant challenge for large language models (LLMs), with performance disproportionately favoring high-resource languages. Drawing inspiration from cognitive neuroscience, which suggests that human…

Computation and Language · Computer Science 2025-12-12 Weixiang Zhao , Jiahe Guo , Yang Deng , Tongtong Wu , Wenxuan Zhang , Yulin Hu , Xingyu Sui , Yanyan Zhao , Wanxiang Che , Bing Qin , Tat-Seng Chua , Ting Liu

The safe deployment of large language models (LLMs) in high-stakes fields like biomedicine, requires them to be able to reason about cause and effect. We investigate this ability by testing 13 open-source LLMs on a fundamental task:…

Computation and Language · Computer Science 2026-03-13 Sydney Anuyah , Sneha Shajee-Mohan , Ankit-Singh Chauhan , Sunandan Chakraborty

Retrosynthesis planning, essential in organic synthesis and drug discovery, has greatly benefited from recent AI-driven advancements. Nevertheless, existing methods frequently face limitations in both applicability and explainability.…

Computational Engineering, Finance, and Science · Computer Science 2025-07-24 Situo Zhang , Hanqi Li , Lu Chen , Zihan Zhao , Xuanze Lin , Zichen Zhu , Bo Chen , Xin Chen , Kai Yu

The development of highly fluent large language models (LLMs) has prompted increased interest in assessing their reasoning and problem-solving capabilities. We investigate whether several LLMs can solve a classic type of deductive reasoning…

Computation and Language · Computer Science 2024-04-16 Spencer M. Seals , Valerie L. Shalin

Large Language Models (LLMs) have demonstrated strong reasoning capabilities in solving complex problems. However, current approaches primarily enhance reasoning through the elaboration of thoughts while neglecting the diversity of…

Computation and Language · Computer Science 2025-04-25 Danqing Wang , Jianxin Ma , Fei Fang , Lei Li

While Large Language Models (LLMs) achieve near-human performance on standard benchmarks, their capabilities often fail to generalize to complex, real-world problems. To bridge this gap, we introduce DeepQuestion, a scalable, automated…

Computation and Language · Computer Science 2026-03-02 Ali Khoramfar , Ali Ramezani , Mohammad Mahdi Mohajeri , Mohammad Javad Dousti , Majid Nili Ahmadabadi , Heshaam Faili

Recent advances in large language models (LLMs) and biomedical foundation models (BioFMs) have achieved strong results in biological text reasoning, molecular modeling, and single-cell analysis, yet they remain siloed in disjoint embedding…

Quantitative Methods · Quantitative Biology 2025-10-03 Ching-Huei Tsou , Michal Ozery-Flato , Ella Barkan , Diwakar Mahajan , Ben Shapira

Large language models (LLMs) excel in many natural language tasks, yet they struggle with complex mathemat-ical problem-solving, particularly in symbolic reasoning and maintaining consistent output. This study evalu-ates 10 LLMs with 7 to 8…

Machine Learning · Computer Science 2025-01-29 Evgenii Evstafev

Reasoning-capable language models achieve state-of-the-art performance in diverse complex tasks by generating long, explicit Chain-of-Thought (CoT) traces. While recent works show that base models can acquire such reasoning traces via…

With the increasing use of large language models (LLMs) for generating answers to biomedical questions, it is crucial to evaluate the quality of the generated answers and the references provided to support the facts in the generated…

Computation and Language · Computer Science 2026-02-10 Deepak Gupta , Davis Bartels , Dina Demner-Fushman
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