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Related papers: Few-Shot Distribution-Aligned Flow Matching for Da…

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Generative models like Flow Matching have achieved state-of-the-art performance but are often hindered by a computationally expensive iterative sampling process. To address this, recent work has focused on few-step or one-step generation by…

Machine Learning · Computer Science 2025-07-24 Yi Guo , Wei Wang , Zhihang Yuan , Rong Cao , Kuan Chen , Zhengyang Chen , Yuanyuan Huo , Yang Zhang , Yuping Wang , Shouda Liu , Yuxuan Wang

Sampling useful three-dimensional molecular structures along with their most favorable conformations is a key challenge in drug discovery. Current state-of-the-art 3D de-novo design flow matching or diffusion-based models are limited to…

Machine Learning · Computer Science 2025-11-24 Riccardo Tedoldi , Ola Engkvist , Patrick Bryant , Hossein Azizpour , Jon Paul Janet , Alessandro Tibo

Diffusion models and Flow Matching generate high-quality samples but are slow at inference, and distilling them into few-step models often leads to instability and extensive tuning. To resolve these trade-offs, we propose Inductive Moment…

Machine Learning · Computer Science 2025-05-16 Linqi Zhou , Stefano Ermon , Jiaming Song

Diffusion and flow-based models have enabled significant progress in generation tasks across various modalities and have recently found applications in predictive learning. However, unlike typical generation tasks that encourage sample…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Yu Zhang , Xingzhuo Guo , Haoran Xu , Jialong Wu , Mingsheng Long

Surgical video datasets are essential for scene understanding, enabling procedural modeling and intra-operative support. However, these datasets are often heavily imbalanced, with rare actions and tools under-represented, which limits the…

Quantitative Methods · Quantitative Biology 2025-10-10 Danush Kumar Venkatesh , Adam Schmidt , Muhammad Abdullah Jamal , Omid Mohareri

Predictive models trained on imbalanced data tend to produce biased results. This problem is exacerbated when there is not just one output label, but a set of them. This is the case for multilabel learning (MLL) algorithms used to classify…

Machine Learning · Computer Science 2025-01-22 Francisco Charte , Miguel Ángel Dávila , María Dolores Pérez-Godoy , María José del Jesus

Current auto-regressive (AR) LLMs, diffusion-based text/image generative models, and recent flow matching (FM) algorithms are capable of generating premium quality text/image samples. However, the inference or sample generation in these…

Machine Learning · Computer Science 2026-03-23 Minyoung Kim

Diffusion and flow-matching models scale because pretraining is supervised regression: a clean sample is noised analytically, and a model regresses against a closed-form target. RL post-training aligns the model with a reward. In image…

Machine Learning · Computer Science 2026-05-19 Andreas Bergmeister , Stefanie Jegelka , Nikolas Nüsken , Carles Domingo-Enrich , Jakiw Pidstrigach

Strong semantic representations improve the convergence and generation quality of diffusion and flow models. Existing approaches largely rely on external models, which require separate training, operate on misaligned objectives, and exhibit…

Computer Vision and Pattern Recognition · Computer Science 2026-03-09 Hila Chefer , Patrick Esser , Dominik Lorenz , Dustin Podell , Vikash Raja , Vinh Tong , Antonio Torralba , Robin Rombach

Estimating causal effects from observational data has become increasingly critical in diverse fields including healthcare, economics, and social policy. The fundamental challenge in causal inference arises from the missing counterfactuals…

Machine Learning · Computer Science 2026-05-08 Yifei Xie , Jian Huang

Most recent diffusion-based methods still show a large gap compared to non-diffusion methods for video frame interpolation, in both accuracy and efficiency. Most of them formulate the problem as a denoising procedure in latent space…

Computer Vision and Pattern Recognition · Computer Science 2025-04-02 Yang Hai , Guo Wang , Tan Su , Wenjie Jiang , Yinlin Hu

While diffusion distillation has enabled one-step generation through methods like Variational Score Distillation, adapting distilled models to emerging new controls -- such as novel structural constraints or latest user preferences --…

Computer Vision and Pattern Recognition · Computer Science 2025-03-13 Yihong Luo , Tianyang Hu , Yifan Song , Jiacheng Sun , Zhenguo Li , Jing Tang

Many approaches have been proposed to use diffusion models to augment training datasets for downstream tasks, such as classification. However, diffusion models are themselves trained on large datasets, often with noisy annotations, and it…

Computer Vision and Pattern Recognition · Computer Science 2023-12-01 Max F. Burg , Florian Wenzel , Dominik Zietlow , Max Horn , Osama Makansi , Francesco Locatello , Chris Russell

Many real-world applications of flow-based generative models desire a diverse set of samples that cover multiple modes of the target distribution. However, the predominant approach for obtaining diverse sets is not sample-efficient, as it…

Machine Learning · Computer Science 2025-04-11 Mashrur M. Morshed , Vishnu Boddeti

We propose a framework using normalizing-flow based models, SELF-Referencing Embedded Strings, and multi-objective optimization that efficiently generates small molecules. With an initial training set of only 100 small molecules, FastFlows…

Chemical Physics · Physics 2022-02-01 Nathan C. Frey , Vijay Gadepally , Bharath Ramsundar

In generative modeling, we often wish to produce samples that maximize a user-specified reward such as aesthetic quality or alignment with human preferences, a problem known as \textit{guidance}. Despite their widespread use, existing…

Machine Learning · Computer Science 2026-05-21 Jerry Y. Huang , Justin Lin , Sheel Shah , Kartik Nair , Nicholas M. Boffi

Image enhancement holds extensive applications in real-world scenarios due to complex environments and limitations of imaging devices. Conventional methods are often constrained by their tailored models, resulting in diminished robustness…

Computer Vision and Pattern Recognition · Computer Science 2024-06-04 Yixuan Zhu , Wenliang Zhao , Ao Li , Yansong Tang , Jie Zhou , Jiwen Lu

The adversarial methods showed advanced performance by producing synthetic images to mitigate the domain shift, a common problem due to the hardship of acquiring labelled data in medical field. Most existing studies focus on modifying the…

Image and Video Processing · Electrical Eng. & Systems 2023-05-09 Xinwen Zhang , Chaoyi Zhang , Dongnan Liu , Qianbi Yu , Weidong Cai

Diffusion models exhibit remarkable generative capability, but their high latency limits practical deployment. Many studies have attempted to reduce sampling steps to accelerate inference. Among them, MeanFlow has attracted considerable…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Xiao He , Yang Li , Peizhen Zhang , Songtao Liu , Zhao Zhong , Nannan Wang

We present a new method for making diffusion models faster to sample. The method distills many-step diffusion models into few-step models by matching conditional expectations of the clean data given noisy data along the sampling trajectory.…

Machine Learning · Computer Science 2024-06-07 Tim Salimans , Thomas Mensink , Jonathan Heek , Emiel Hoogeboom
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