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Single-molecule approaches to biology offer a powerful new vision to elucidate the mechanisms that underpin the functioning of living cells. However, conventional optical single molecule spectroscopy techniques such as F\"orster…
Fast, volumetric imaging that integrates multiple imaging modalities is essential for probing dynamic, heterogeneous soft and biological matter. Here, we present the M3Scope, a simple yet versatile multiplane microscope that extends…
Confocal microscopy is the standard approach for obtaining volumetric images of a sample with high axial and lateral resolution, especially when dealing with scattering samples. Unfortunately, a confocal microscope is quite expensive…
Light field imaging extends the traditional photography by capturing both spatial and angular distribution of light, which enables new capabilities, including post-capture refocusing, post-capture aperture control, and depth estimation from…
We introduce and experimentally implement Fourier-plane phase synchronization for optical microscopy, and demonstrate its performance with interferometric scattering microscopy. By combining a photothermal phase plate and laser beam…
Photonic lanterns allow for a low-loss transformation of a multimode waveguide into a discrete number of single-mode waveguides and vice versa, thus, enabling the use of single-mode photonic technologies in multimode systems. In this…
When light propagates through a complex medium, such as a multimode optical fibre (MMF), the spatial information it carries is scrambled. In this work we experimentally demonstrate an all-optical strategy to unscramble this light again. We…
Photonic lanterns allow the decomposition of highly multimodal light into a simplified modal basis such as single-moded and/or few-moded. They are increasingly finding uses in astronomy, optics and telecommunications. Calculating…
Multi-Pixel Photon Counter (MPPC) has been recently emerged and realized as a great type of Silicon Photomultiplier to replace or compensate for the conventional vacuum-based Photomultiplier tubes. MPPC provides many striking features such…
We demonstrate a new computational illumination technique that achieves large space-bandwidth-time product, for quantitative phase imaging of unstained live samples in vitro. Microscope lenses can have either large field of view (FOV) or…
The next generations of ground-based cosmic microwave background experiments will require polarisation sensitive, multichroic pixels of large focal planes comprising several thousand detectors operating at the photon noise limit. One…
An integrated microscope that combines different optical techniques for simultaneous imaging is demonstrated. The microscope enables spectral-domain optical coherence microscopy based on optical backscatter, and multi-photon microscopy for…
Ground-based direct imaging of exoplanets at high contrast requires precise correction of atmospheric turbulence using adaptive optics (AO). The planet-to-star contrast ratio at small angular separations from the host star is often limited…
Ophthalmic image segmentation serves as a critical foundation for ocular disease diagnosis. Although fully convolutional neural networks (CNNs) are commonly employed for segmentation, they are constrained by inductive biases and face…
Lensless on-chip microscopy has shown great potential for biomedical imaging due to its large-area and high-throughput imaging capabilities. By combining the pixel super-resolution (PSR) technique, it can improve the resolution beyond the…
We have developed an automatic method for segmenting fluorescence lifetime (FLT) imaging microscopy (FLIM) images of cells inspired by a multi-resolution community detection (MCD) based network segmentation method. The image processing…
Accurate classification of histological subtypes of non-small cell lung cancer (NSCLC) is essential in the era of precision medicine, yet current invasive techniques are not always feasible and may lead to clinical complications. This study…
Phase and polarisation of coherent light are highly perturbed by interaction with microstructural changes in pre-malignant tissue, holding promise for label-free early cancer detection in endoscopically accessible tissues such as the…
Holographic multimode fibre endoscopes have recently shown their ability to unveil and monitor deep brain structures with sub-micrometre resolution, establishing themselves as a minimally-invasive technology with promising applications in…
Fluorescent observation of cells generally suffers from the limited axial resolution due to the elongated point spread function of the microscope optics. Consequently, three-dimensional imaging results in axial resolution being several…