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The paradigm shift toward structure-driven molecule generation has been propelled by advances in deep generative models, such as variational auto-encoders and diffusion models. However, these generative models for molecular design remain…

Machine Learning · Computer Science 2026-04-17 Peidong Liu , Wenbo Zhang , Wei Ju , Jiancheng Lv , Xianggen Liu

Recent successes in Generative Adversarial Networks (GAN) have affirmed the importance of using more data in GAN training. Yet it is expensive to collect data in many domains such as medical applications. Data Augmentation (DA) has been…

Computer Vision and Pattern Recognition · Computer Science 2021-02-24 Ngoc-Trung Tran , Viet-Hung Tran , Ngoc-Bao Nguyen , Trung-Kien Nguyen , Ngai-Man Cheung

We study the problem of distribution shift generally arising in machine-learning augmented hybrid simulation, where parts of simulation algorithms are replaced by data-driven surrogates. We first establish a mathematical framework to…

Numerical Analysis · Mathematics 2025-06-17 Jiaxi Zhao , Qianxiao Li

Detecting out of distribution (OOD) samples is of paramount importance in all Machine Learning applications. Deep generative modeling has emerged as a dominant paradigm to model complex data distributions without labels. However, prior work…

Machine Learning · Computer Science 2021-01-05 Gowthami Somepalli , Yexin Wu , Yogesh Balaji , Bhanukiran Vinzamuri , Soheil Feizi

We propose a framework for adversarial training that relies on a sample rather than a single sample point as the fundamental unit of discrimination. Inspired by discrepancy measures and two-sample tests between probability distributions, we…

Machine Learning · Computer Science 2017-07-11 Chengtao Li , David Alvarez-Melis , Keyulu Xu , Stefanie Jegelka , Suvrit Sra

The Generative Adversarial Network (GAN) was recently introduced in the literature as a novel machine learning method for training generative models. It has many applications in statistics such as nonparametric clustering and nonparametric…

Machine Learning · Statistics 2023-06-26 Sehwan Kim , Qifan Song , Faming Liang

Simulating complex physical systems often involves solving partial differential equations (PDEs) with some closures due to the presence of multi-scale physics that cannot be fully resolved. Therefore, reliable and accurate closure models…

Computational Physics · Physics 2020-02-19 Jin-Long Wu , Karthik Kashinath , Adrian Albert , Dragos Chirila , Prabhat , Heng Xiao

Protein dynamics play a crucial role in protein biological functions and properties, and their traditional study typically relies on time-consuming molecular dynamics (MD) simulations conducted in silico. Recent advances in generative…

Biomolecules · Quantitative Biology 2025-06-02 Jiarui Lu , Xiaoyin Chen , Stephen Zhewen Lu , Aurélie Lozano , Vijil Chenthamarakshan , Payel Das , Jian Tang

The fact that image datasets are often imbalanced poses an intense challenge for deep learning techniques. In this paper, we propose a method to restore the balance in imbalanced images, by coalescing two concurrent methods, generative…

Machine Learning · Computer Science 2020-04-09 Pourya Shamsolmoali , Masoumeh Zareapoor , Linlin Shen , Abdul Hamid Sadka , Jie Yang

Using simulations or experiments performed at some set of temperatures to learn about the physics or chemistry at some other arbitrary temperature is a problem of immense practical and theoretical relevance. Here we develop a framework…

Statistical Mechanics · Physics 2022-10-17 Yihang Wang , Lukas Herron , Pratyush Tiwary

Conditional Generative Adversarial Networks (cGANs) extend the standard unconditional GAN framework to learning joint data-label distributions from samples, and have been established as powerful generative models capable of generating…

Computer Vision and Pattern Recognition · Computer Science 2021-11-30 Ligong Han , Martin Renqiang Min , Anastasis Stathopoulos , Yu Tian , Ruijiang Gao , Asim Kadav , Dimitris Metaxas

Most current studies on survey analysis and risk tolerance modelling lack professional knowledge and domain-specific models. Given the effectiveness of generative adversarial learning in cross-domain information, we design an Asymmetric…

Machine Learning · Computer Science 2020-10-07 Zhe Liu , Lina Yao , Xianzhi Wang , Lei Bai , Jake An

Domain Adaptation is an actively researched problem in Computer Vision. In this work, we propose an approach that leverages unsupervised data to bring the source and target distributions closer in a learned joint feature space. We…

Computer Vision and Pattern Recognition · Computer Science 2018-04-16 Swami Sankaranarayanan , Yogesh Balaji , Carlos D. Castillo , Rama Chellappa

Test-Time Adaptation (TTA) has emerged as a promising paradigm for enhancing the generalizability of models. However, existing mainstream TTA methods, predominantly operating at batch level, often exhibit suboptimal performance in complex…

Machine Learning · Computer Science 2024-10-15 Yige Yuan , Bingbing Xu , Teng Xiao , Liang Hou , Fei Sun , Huawei Shen , Xueqi Cheng

Anomaly detection suffered from the lack of anomalies due to the diversity of abnormalities and the difficulties of obtaining large-scale anomaly data. Semi-supervised anomaly detection methods are often used to solely leverage normal data…

Computer Vision and Pattern Recognition · Computer Science 2023-04-11 Jian Shi , Ni Zhang

We introduce and motivate generative modeling as a central task for machine learning and provide a critical view of the algorithms which have been proposed for solving this task. We overview how generative modeling can be defined…

Machine Learning · Computer Science 2021-03-02 Alex Lamb

Despite remarkable achievements in deep learning across various domains, its inherent vulnerability to adversarial examples still remains a critical concern for practical deployment. Adversarial training has emerged as one of the most…

Machine Learning · Computer Science 2024-11-06 Junhao Dong , Xinghua Qu , Z. Jane Wang , Yew-Soon Ong

Adversarial learning methods are a promising approach to training robust deep networks, and can generate complex samples across diverse domains. They also can improve recognition despite the presence of domain shift or dataset bias: several…

Computer Vision and Pattern Recognition · Computer Science 2017-02-20 Eric Tzeng , Judy Hoffman , Kate Saenko , Trevor Darrell

Test-time adaptation (TTA) enhances the zero-shot robustness under distribution shifts by leveraging unlabeled test data during inference. Despite notable advances, several challenges still limit its broader applicability. First, most…

Computer Vision and Pattern Recognition · Computer Science 2026-05-04 Youjia Zhang , Youngeun Kim , Young-Geun Choi , Hongyeob Kim , Huiling Liu , Sungeun Hong

Learning to sample from complex unnormalized distributions is a fundamental challenge in computational physics and machine learning. While score-based and variational methods have achieved success in continuous domains, extending them to…

Machine Learning · Statistics 2026-03-11 Lei Li , Zhen Wang , Lishuo Zhang