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Denoising-based generative models, particularly diffusion and flow matching algorithms, have achieved remarkable success. However, aligning their output distributions with complex downstream objectives, such as human preferences,…

Machine Learning · Computer Science 2025-08-29 Luozhijie Jin , Zijie Qiu , Jie Liu , Zijie Diao , Lifeng Qiao , Ning Ding , Alex Lamb , Xipeng Qiu

The vision for precision medicine is to use individual patient characteristics to inform a personalized treatment plan that leads to the best healthcare possible for each patient. Mobile technologies have an important role to play in this…

In this paper, a new population-guided parallel learning scheme is proposed to enhance the performance of off-policy reinforcement learning (RL). In the proposed scheme, multiple identical learners with their own value-functions and…

Machine Learning · Computer Science 2020-01-10 Whiyoung Jung , Giseung Park , Youngchul Sung

In this paper, we study the problem of blood glucose forecasting and provide a deep personalized solution. Predicting blood glucose level in people with diabetes has significant value because health complications of abnormal glucose level…

Machine Learning · Computer Science 2021-09-08 Mohammadreza Armandpour , Brian Kidd , Yu Du , Jianhua Z. Huang

Algorithmic recourse seeks to provide individuals with actionable recommendations that increase their chances of receiving favorable outcomes from automated decision systems (e.g., loan approvals). While prior research has emphasized…

Machine Learning · Computer Science 2026-02-03 Marina Ceccon , Alessandro Fabris , Goran Radanović , Asia J. Biega , Gian Antonio Susto

Diabetes, a pervasive and enduring health challenge, imposes significant global implications on health, financial healthcare systems, and societal well-being. This study undertakes a comprehensive exploration of various structural learning…

Machine Learning · Computer Science 2024-03-22 Sheresh Zahoor , Anthony C. Constantinou , Tim M Curtis , Mohammed Hasanuzzaman

Due to the trial-and-error nature, it is typically challenging to apply RL algorithms to safety-critical real-world applications, such as autonomous driving, human-robot interaction, robot manipulation, etc, where such errors are not…

Machine Learning · Computer Science 2024-09-25 Weiye Zhao , Yifan Sun , Feihan Li , Rui Chen , Ruixuan Liu , Tianhao Wei , Changliu Liu

This work proposes a control-informed reinforcement learning (CIRL) framework that integrates proportional-integral-derivative (PID) control components into the architecture of deep reinforcement learning (RL) policies. The proposed…

Systems and Control · Electrical Eng. & Systems 2024-08-28 Maximilian Bloor , Akhil Ahmed , Niki Kotecha , Mehmet Mercangöz , Calvin Tsay , Ehecactl Antonio Del Rio Chanona

We present the design and \textit{in-silico} evaluation of a closed-loop insulin delivery algorithm to treat type 1 diabetes (T1D) consisting in a data-driven multi-step-ahead blood glucose (BG) predictor integrated into a Linear…

Systems and Control · Electrical Eng. & Systems 2023-07-25 Eleonora Maria Aiello , Mehrad Jaloli , Marzia Cescon

Reinforcement Learning (RL) is a method for learning decision-making tasks that could enable robots to learn and adapt to their situation on-line. For an RL algorithm to be practical for robotic control tasks, it must learn in very few…

Artificial Intelligence · Computer Science 2015-03-19 Todd Hester , Michael Quinlan , Peter Stone

We present a fully closed-loop design for an artificial pancreas (AP) which regulates the delivery of insulin for the control of Type I diabetes. Our AP controller operates in a fully automated fashion, without requiring any manual…

Systems and Control · Computer Science 2017-09-29 Nicola Paoletti , Kin Sum Liu , Scott A. Smolka , Shan Lin

Reinforcement learning (RL) agents with pre-specified reward functions cannot provide guaranteed safety across variety of circumstances that an uncertain system might encounter. To guarantee performance while assuring satisfaction of safety…

Artificial Intelligence · Computer Science 2021-04-20 Aquib Mustafa , Majid Mazouchi , Subramanya Nageshrao , Hamidreza Modares

We propose a reinforcement learning (RL)-based system that would automatically prescribe a hypothetical patient medication that may help the patient with their mental health-related speech disfluency, and adjust the medication and the…

A critical challenge facing clinicians managing chronic disease interventions is sustaining long-run patient health given limited information and resources. Digital therapeutics (DTs) provide a cost-effective way to manage interventions at…

Machine Learning · Computer Science 2026-05-26 Eric Pulick , Stephanie Carpenter , Matthew Buman , Yonatan Mintz

The goal of this paper is to propose a new mathematical model for the combined effect of different treatments and lifestyles on the glucose-insulin dynamics of Type 2 diabetes (T2D) patients. The model gives the possibility to take into…

Systems and Control · Electrical Eng. & Systems 2023-01-11 Mohamad Al Ahdab , John Leth , Torben Knudsen , Peter Vestergaard , Henrik Clausen

Reinforcement learning (RL) algorithms for real-world robotic applications need a data-efficient learning process and the ability to handle complex, unknown dynamical systems. These requirements are handled well by model-based and…

Robotics · Computer Science 2017-06-20 Yevgen Chebotar , Karol Hausman , Marvin Zhang , Gaurav Sukhatme , Stefan Schaal , Sergey Levine

Humanoid table tennis (TT) demands rapid perception, proactive whole-body motion, and agile footwork under strict timing--capabilities that remain difficult for end-to-end control policies. We propose a reinforcement learning (RL) framework…

Reinforcement Learning (RL) is increasingly applied to large-scale decision-making problems like logistics, scheduling, and recommender systems, but existing algorithms struggle with the curse of dimensionality in such large discrete action…

Machine Learning · Computer Science 2026-05-12 Heiko Hoppe , Fabian Akkerman , Wouter van Heeswijk , Maximilian Schiffer

Diabetes is a chronic metabolic disorder characterized by elevated blood glucose levels due to impaired insulin production or function. Two main forms are recognized: type 1 diabetes (T1D), which involves autoimmune destruction of…

Genomics · Quantitative Biology 2026-02-11 Maria De La Luz Lomboy Toledo , Daniel Onah

Attention-based sequential recommendation methods have shown promise in accurately capturing users' evolving interests from their past interactions. Recent research has also explored the integration of reinforcement learning (RL) into these…

Machine Learning · Computer Science 2024-04-19 Melissa Mozifian , Tristan Sylvain , Dave Evans , Lili Meng