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Multimodal clinical reasoning in the field of gastrointestinal (GI) oncology necessitates the integrated interpretation of endoscopic imagery, radiological data, and biochemical markers. Despite the evident potential exhibited by Multimodal…

Large language models are increasingly being assembled into medical multi-agent systems that emulate multidisciplinary consultation through specialist roles, peer review and consensus formation. In clinical decision support, however,…

Computation and Language · Computer Science 2026-05-28 Yinghao Zhu , Lei Gu , Zixiang Wang , Haoran Sang , Dehao Sui , Wen Tang , Lan Mi , Yasha Wang , Junyi Gao , Liang Yao , Tianfan Fu , Ewen Harrison , Lequan Yu , Liantao Ma

While large language models are capable diagnostic tools, the impact of multi-agent topology on diagnostic accuracy remains underexplored. This study evaluates four agent topologies, Control (single agent), Hierarchical, Adversarial, and…

Multiagent Systems · Computer Science 2026-03-10 Ahmed Almasoud

Multidisciplinary team (MDT) consultations are the gold standard for cancer care decision-making, yet current practice lacks structured mechanisms for quantifying consensus and ensuring decision traceability. We introduce a Multi-Agent…

Multiagent Systems · Computer Science 2025-12-17 Xudong Han , Xianglun Gao , Xiaoyi Qu , Zhenyu Yu

There is growing interest in using machine learning (ML) to support clinical diagnosis, but most approaches rely on static, fully observed datasets and fail to reflect the sequential, resource-aware reasoning clinicians use in practice.…

Artificial Intelligence · Computer Science 2025-11-18 Silas Ruhrberg Estévez , Nicolás Astorga , Mihaela van der Schaar

We propose GAM-Agent, a game-theoretic multi-agent framework for enhancing vision-language reasoning. Unlike prior single-agent or monolithic models, GAM-Agent formulates the reasoning process as a non-zero-sum game between base…

Artificial Intelligence · Computer Science 2025-05-30 Jusheng Zhang , Yijia Fan , Wenjun Lin , Ruiqi Chen , Haoyi Jiang , Wenhao Chai , Jian Wang , Keze Wang

Building effective clinical decision support systems requires the synthesis of complex heterogeneous multimodal data. Such modalities include temporal electronic health records data, medical images, radiology reports, and clinical notes.…

Artificial Intelligence · Computer Science 2026-05-12 Baraa Al Jorf , Farah E. Shamout

Recent multi-agent frameworks have broadened the ability to tackle oncology decision support tasks that require reasoning over dynamic, heterogeneous patient data. We propose Contribution-Aware Medical Multi-Agents (CoMMa), a decentralized…

Artificial Intelligence · Computer Science 2026-02-11 Yichen Wu , Yujin Oh , Sangjoon Park , Kailong Fan , Dania Daye , Hana Farzaneh , Xiang Li , Raul Uppot , Quanzheng Li

Collective intelligence from multiple medical experts consistently surpasses individual expertise in clinical diagnosis, particularly for ambiguous medical image segmentation tasks involving unclear tissue boundaries or pathological…

Image and Video Processing · Electrical Eng. & Systems 2025-11-18 Mingzhou Jiang , Jiaying Zhou , Junde Wu , Tianyang Wang , Yueming Jin , Min Xu

With advancements in reasoning capabilities, Large Language Models (LLMs) are increasingly employed for automated judgment tasks. While LLMs-as-Judges offer promise in automating evaluations, current approaches often rely on simplistic…

Artificial Intelligence · Computer Science 2025-10-15 Tianyu Hu , Zhen Tan , Song Wang , Huaizhi Qu , Tianlong Chen

This paper is concerned with evaluating different multiagent learning (MAL) algorithms in problems where individual agents may be heterogenous, in the sense of utilizing different learning strategies, without the opportunity for prior…

Multiagent Systems · Computer Science 2019-07-23 Stefano V. Albrecht , Subramanian Ramamoorthy

Evaluating large language models (LLM) in clinical scenarios is crucial to assessing their potential clinical utility. Existing benchmarks rely heavily on static question-answering, which does not accurately depict the complex, sequential…

Human-Computer Interaction · Computer Science 2025-05-27 Samuel Schmidgall , Rojin Ziaei , Carl Harris , Eduardo Reis , Jeffrey Jopling , Michael Moor

Multimodal artificial intelligence (AI) systems have the potential to enhance clinical decision-making by interpreting various types of medical data. However, the effectiveness of these models across all medical fields is uncertain. Each…

Large Language Models (LLMs) and multi-agent systems have shown impressive capabilities in natural language tasks but face challenges in clinical trial applications, primarily due to limited access to external knowledge. Recognizing the…

Computation and Language · Computer Science 2024-07-23 Ling Yue , Sixue Xing , Jintai Chen , Tianfan Fu

Literature on the modeling and simulation of complex adaptive systems (cas) has primarily advanced vertically in different scientific domains with scientists developing a variety of domain-specific approaches and applications. However,…

Multiagent Systems · Computer Science 2017-08-09 Muaz A. Niazi

Large language models (LLMs) have proven effective in artificial intelligence, where the multi-agent system (MAS) holds considerable promise for healthcare development by achieving the collaboration of LLMs. However, the absence of a…

Artificial Intelligence · Computer Science 2026-05-13 Zhihao Peng , Liuxin Bao , Yixuan Yuan

The impressive performance of generalist large language models (LLMs) such as GPT and Claude in healthcare raises a critical question: will domain-specific medical specialist models become obsolete? We argue that the future of medical…

Artificial Intelligence · Computer Science 2026-05-29 Yanan Wang , Shuaicong Hu , Jian Liu , Guohui Zhou , Aiguo Wang , Cuiwei Yang

Multi-agent debate improves LLM reasoning, yet agreement among agents is not evidence of correctness. When agents converge on a wrong answer through social reinforcement, consensus-based stopping commits that error to an automated action…

Artificial Intelligence · Computer Science 2026-04-10 Mengdie Flora Wang , Haochen Xie , Guanghui Wang , Aijing Gao , Guang Yang , Ziyuan Li , Qucy Wei Qiu , Fangwei Han , Hengzhi Qiu , Yajing Huang , Bing Zhu , Jae Oh Woo

Mental health assessment is crucial for early intervention and effective treatment, yet traditional clinician-based approaches are limited by the shortage of qualified professionals. Recent advances in artificial intelligence have sparked…

Computation and Language · Computer Science 2025-08-18 Jinpeng Hu , Ao Wang , Qianqian Xie , Hui Ma , Zhuo Li , Dan Guo

The selection of appropriate medical imaging procedures is a critical and complex clinical decision, guided by extensive evidence-based standards such as the ACR Appropriateness Criteria (ACR-AC). However, the underutilization of these…

Quantitative Methods · Quantitative Biology 2025-10-07 Satrio Pambudi , Filippo Menolascina