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We present a nonlinear data-driven Model Predictive Control (MPC) algorithm for deep brain stimulation (DBS) for the treatment of Parkinson's disease (PD). Although DBS is typically implemented in open-loop, closed-loop DBS (CLDBS) uses the…

Optimization and Control · Mathematics 2025-09-09 Sebastian Steffen , Mark Cannon

Parkinson's Disease (PD) is a chronic, degenerative disorder which leads to a range of motor and cognitive symptoms. PD diagnosis is a challenging task since its symptoms are very similar to other diseases such as normal ageing and…

Machine Learning · Computer Science 2021-01-15 Mohamad Alissa

Parkinson's disease (PD) presents a growing global challenge, affecting over 10 million individuals, with prevalence expected to double by 2040. Early diagnosis remains difficult due to the late emergence of motor symptoms and limitations…

Machine Learning · Computer Science 2025-10-21 Arianna Francesconi , Donato Cappetta , Fabio Rebecchi , Paolo Soda , Valerio Guarrasi , Rosa Sicilia

Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide and affects around 1% of the (60+ years old) elderly population in industrial nations. More than 80% of PD patients suffer from motor symptoms, which…

Parkinson's disease (PD), a severe and progressive neurological illness, affects millions of individuals worldwide. For effective treatment and management of PD, an accurate and early diagnosis is crucial. This study presents a deep…

Signal Processing · Electrical Eng. & Systems 2023-08-16 Niloufar Delfan , Mohammadreza Shahsavari , Sadiq Hussain , Robertas Damaševičius , U. Rajendra Acharya

Parkinson's disease (PD) belongs to the class of neurodegenerative disorders that affect the central nervous system. It is usually defined as the gradual loss of dopaminergic neurons in the substantia nigra pars compacta, which causes both…

Neurons and Cognition · Quantitative Biology 2024-11-01 Hina Shaheen , Roderick Melnik

Parkinson's disease (PD) is a progressive neurodegenerative disorder that, in addition to directly impairing functional mobility, is frequently associated with vocal impairments such as hypophonia and dysarthria, which typically manifest in…

The paper presents a novel approach, based on deep learning, for diagnosis of Parkinson's disease through medical imaging. The approach includes analysis and use of the knowledge extracted by Deep Convolutional and Recurrent Neural Networks…

Machine Learning · Computer Science 2019-11-26 James Wingate , Ilianna Kollia , Luc Bidaut , Stefanos Kollias

In many clinical trials studying neurodegenerative diseases such as Parkinson's disease (PD), multiple longitudinal outcomes are collected to fully explore the multidimensional impairment caused by this disease. If the outcomes deteriorate…

Applications · Statistics 2017-05-18 Jue Wang , Sheng Luo , Liang Li

PPINtonus is a system for the early detection of Parkinson's Disease (PD) utilizing deep-learning tonal analysis, providing a cost-effective and accessible alternative to traditional neurological examinations. Partnering with the…

Audio and Speech Processing · Electrical Eng. & Systems 2024-06-06 Varun Reddy

Parkinson's disease (PD), characterized by its incurable nature, rapid progression, and severe disability, poses significant challenges to the lives of patients and their families. Given the aging population, the need for early detection of…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Wei Huang , Yinxuan Xu , Yintao Zhou , Zhengyu Li , Jing Huang , Meng Pang

Parkinsons disease, the fastest growing neurodegenerative disorder globally, has seen a 50 percent increase in cases within just two years. As speech, memory, and motor symptoms worsen over time, early diagnosis is crucial for preserving…

Quantitative Methods · Quantitative Biology 2024-12-02 Diya Vatsavai , Anya Iyer , Ashwin A. Nair

Parkinson's Disease (PD) is one of the most common types of neurological diseases caused by progressive degeneration of dopamin- ergic neurons in the brain. Even though there is no fixed cure for this neurodegenerative disease, earlier…

Computer Vision and Pattern Recognition · Computer Science 2018-06-21 Sara Soltaninejad , Irene Cheng , Anup Basu

Preoperative improvement rate prediction for Parkinson's disease surgery is clinically important yet difficult because imaging signals are subtle and patients are heterogeneous. We address this setting, where only information available…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Yand Wang , Chen Zhang , Lanyun Zhu , Yixin Chen , Qunbo Wang , Yutong Bai , Jurgen Germann , Yinghong Wen , Shuai Shao

One of the most catastrophic neurological disorders worldwide is Parkinson's Disease. Along with it, the treatment is complicated and abundantly expensive. The only effective action to control the progression is diagnosing it in the early…

Machine Learning · Computer Science 2023-10-23 Md. Taufiqul Haque Khan Tusar , Md. Touhidul Islam , Abul Hasnat Sakil

Background: Parkinson's disease (PD) is a prevalent long-term neurodegenerative disease. Though the diagnostic criteria of PD are relatively well defined, the current medical imaging diagnostic procedures are expertise-demanding, and thus…

Quantitative Methods · Quantitative Biology 2019-02-27 Jiahang Xu , Fangyang Jiao , Yechong Huang , Xinzhe Luo , Qian Xu , Ling Li , Xueling Liu , Chuantao Zuo , Ping Wu , Xiahai Zhuang

Parkinson's disease (PD) is projected to increase substantially due to population aging, making early diagnosis increasingly important, as timely detection may delay progression and reduce long-term complications. Retinal microvasculature…

Parkinson's disease (PD), a degenerative disorder of the central nervous system, is commonly diagnosed using functional medical imaging techniques such as single-photon emission computed tomography (SPECT). In this study, we utilized two…

Machine Learning · Computer Science 2025-01-22 Guan-Hua Huang , Wan-Chen Lai , Tai-Been Chen , Chien-Chin Hsu , Huei-Yung Chen , Yi-Chen Wu , Li-Ren Yeh

This paper presents a new method for medical diagnosis of neurodegenerative diseases, such as Parkinson's, by extracting and using latent information from trained Deep convolutional, or convolutional-recurrent Neural Networks (DNNs). In…

Machine Learning · Computer Science 2019-01-24 Ilianna Kollia , Andreas-Georgios Stafylopatis , Stefanos Kollias

Parkinson's Disease (PD) is a devastating neurodegenerative disorder that affects millions of people around the globe. Many researchers are continuously working to understand PD and develop treatments to improve the condition of PD…

Applications · Statistics 2025-12-16 Malinda Iluppangama , Dilmi Abeywardana , Chris Tsokos