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The bottleneck in enhanced sampling lies in finding collective variables (CVs) that can effectively accelerate protein conformational changes. True reaction coordinates (tRCs) that can predict the committor are considered the optimal CVs,…

Chemical Physics · Physics 2024-12-06 Huiyu Li , Ao Ma

Enhanced sampling methods are indispensable in computational physics and chemistry, where atomistic simulations cannot exhaustively sample the high-dimensional configuration space of dynamical systems due to the sampling problem. A class of…

Chemical Physics · Physics 2024-04-04 Jakub Rydzewski , Ming Chen , Tushar K. Ghosh , Omar Valsson

We propose a novel measure valued process which models the behaviour of chemical reaction networks in spatially heterogeneous systems. It models reaction dynamics between different molecular species and continuous movement of molecules in…

Probability · Mathematics 2022-01-12 Lea Popovic , Amandine Veber

In modern day simulations of many-body systems much of the computational complexity is shifted to the identification of slowly changing molecular order parameters called collective variables (CV) or reaction coordinates. A vast array of…

Statistical Mechanics · Physics 2016-04-27 Pratyush Tiwary , B. J. Berne

Computing accurate reaction rates is a central challenge in computational chemistry and biology because of the high cost of free energy estimation with unbiased molecular dynamics. In this work, a data-driven machine learning algorithm is…

Computational Physics · Physics 2020-12-08 Lixin Sun , Jonathan Vandermause , Simon Batzner , Yu Xie , David Clark , Wei Chen , Boris Kozinsky

We introduce EChemDID, a model to describe electrochemical driving force in reactive molecular dynamics simulations. The method describes the equilibration of external electrochemical potentials (voltage) within metallic structures and…

Materials Science · Physics 2015-09-02 Nicolas Onofrio , Alejandro Strachan

Understanding the evolution of electrified solid-liquid interfaces during electrochemical reactions is crucial. However, capturing the dynamic behavior of the interfaces with high temporal resolution and accuracy over long timescales…

Chemical Physics · Physics 2024-11-26 Letian Chen , Yun Tian , Xu Hu , Suya Chen , Huijuan Wang , Xu Zhang , Zhen Zhou

Accurately predicting chemical reaction outcomes and potential byproducts is a fundamental task of modern chemistry, enabling the efficient design of synthetic pathways and driving progress in chemical science. Reaction mechanism, which…

Chemical Physics · Physics 2025-03-14 Shuan Chen , Kye Sung Park , Taewan Kim , Sunkyu Han , Yousung Jung

Collective variable (CV) or order parameter based enhanced sampling algorithms have achieved great success due to their ability to efficiently explore the rough potential energy landscapes of complex systems. However, the degeneracy of…

Chemical Physics · Physics 2018-07-11 Jing Zhang , Ming Chen

A mathematical model for chemical reactions in electrolytes is developed using an Energy variational method consistent with classical thermodynamics. Electrostatics and chemical reactions are included in properly defined energetic and…

Chemical Physics · Physics 2022-07-08 Shixin Xu , Robert Eisenberg , Zilong Song , Huaxiong Huang

Quantum-mechanically-driven charge polarization and charge transfer are ubiquitous in biomolecular systems, controlling reaction rates, allosteric interactions, ligand-protein binding, membrane transport, and dynamically-driven structural…

Chemical Physics · Physics 2021-06-09 Susan R. Atlas

We lay the foundation of a circuit theory for chemical reaction networks. Chemical reactions are grouped into chemical modules solely characterized by their current-concentration characteristic, as electrical devices by their…

Molecular Networks · Quantitative Biology 2023-07-27 Francesco Avanzini , Nahuel Freitas , Massimiliano Esposito

Quantum Molecular Dynamics (QMD) calculations of central collisions between heavy nuclei are used to study fragment production and the creation of collective flow. It is shown that the final phase space distributions are compatible with the…

Electronic coherences are key to understanding and controlling photo-induced molecular transformations. We identify a crucial quantum-mechanical feature of electron-nuclear correlation, the projected nuclear quantum momenta, essential to…

Chemical Physics · Physics 2024-11-13 Evaristo Villaseco Arribas , Neepa T. Maitra

The study of electronic transitions within a molecule connected to the absorption or emission of light is a common task in the process of the design of new materials. The transitions are complex quantum mechanical processes and a detailed…

Human-Computer Interaction · Computer Science 2021-06-03 Talha Bin Masood , Signe Sidwall Thygesen , Mathieu Linares , Alexei I. Abrikosov , Vijay Natarajan , Ingrid Hotz

Classical theories of chemical kinetics assume independent reactions in dilute solutions, whose rates are determined by mean concentrations. In condensed matter, strong interactions alter chemical activities and create inhomogeneities that…

Materials Science · Physics 2013-04-17 Martin Z. Bazant

Chemical bonding is the stabilization of a composite molecular system caused by different interactions in and between the subsystems, among the strong kinds of bonding is covalent bonding especially important. Characteristic for covalent…

Chemical Physics · Physics 2022-05-03 Alexander F. Sax

Investigating processes in complex molecular systems, which are characterized by many variables, is a crucial problem in computational physics. These systems can be reduced to a few meaningful degrees of freedom known as collective…

Chemical Physics · Physics 2024-05-27 Tuğçe Gökdemir , Jakub Rydzewski

We propose a new and general formalism for elementary chemical reactions where quantum electronic variables are used as reaction coordinates. This formalism is in principle applicable to all kinds of chemical reactions ionic or covalent.…

Chemical Physics · Physics 2014-01-29 S. Aubry

In this second paper we complete the classical description of an isolated system of "charged positive-energy particles, with Grassmann-valued electric charges and mutual Coulomb interaction, plus a transverse electro-magnetic field" in the…

High Energy Physics - Theory · Physics 2015-05-13 David Alba , Horace W. Crater , Luca Lusanna