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Fetal brain magnetic resonance imaging (MRI) offers exquisite images of the developing brain but is not suitable for second-trimester anomaly screening, for which ultrasound (US) is employed. Although expert sonographers are adept at…

Image and Video Processing · Electrical Eng. & Systems 2020-08-21 Jianbo Jiao , Ana I. L. Namburete , Aris T. Papageorghiou , J. Alison Noble

Deep learning models have emerged as a powerful tool for various medical applications. However, their success depends on large, high-quality datasets that are challenging to obtain due to privacy concerns and costly annotation. Generative…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Milad Yazdani , Yasamin Medghalchi , Pooria Ashrafian , Ilker Hacihaliloglu , Dena Shahriari

Abdominal CT data are limited by high annotation costs and privacy constraints, which hinder the development of robust segmentation and diagnostic models. We present a Prior-Integrated Variation Modeling (PIVM) framework, a diffusion-based…

Computer Vision and Pattern Recognition · Computer Science 2026-03-25 Dinglun He , Baoming Zhang , Xu Wang , Yao Hao , Deshan Yang , Ye Duan

Attenuation correction is an essential requirement of positron emission tomography (PET) image reconstruction to allow for accurate quantification. However, attenuation correction is particularly challenging for PET-MRI as neither PET nor…

Objective: Cone-beam computed tomography (CBCT) provides a low-dose imaging alternative to conventional CT, but suffers from noise, scatter, and artifacts that degrade image quality. Synthetic CT (sCT) aims to translate CBCT to high-quality…

Medical Physics · Physics 2025-09-23 Alzahra Altalib , Chunhui Li , Alessandro Perelli

Accurate targeting is critical for the effectiveness of transcranial focused ultrasound (tFUS) neuromodulation. While CT provides accurate skull acoustic properties, its ionizing radiation and poor soft tissue contrast limit clinical…

Medical Physics · Physics 2025-07-14 Hengyu Gao , Shaodong Ding , Ziyang Liu , Jiefu Zhang , Bolun Li , Zhiwu An , Li Wang , Jing Jing , Tao Liu , Yubo Fan , Zhongtao Hu

Magnetic Resonance (MR) Imaging and Computed Tomography (CT) are the primary diagnostic imaging modalities quite frequently used for surgical planning and analysis. A general problem with medical imaging is that the acquisition process is…

Image and Video Processing · Electrical Eng. & Systems 2020-06-08 Vismay Agrawal , Avinash Kori , Vikas Kumar Anand , Ganapathy Krishnamurthi

Low-dose CT (LDCT) denoising remains an important yet challenging problem in medical imaging. Although recent learning-based methods have shown promising performance, those optimized using classical pixel-level objectives often produce…

Image and Video Processing · Electrical Eng. & Systems 2026-05-19 Jianxu Wang , Qing Lyu , Ge Wang

The cycleGAN is becoming an influential method in medical image synthesis. However, due to a lack of direct constraints between input and synthetic images, the cycleGAN cannot guarantee structural consistency between these two images, and…

Computer Vision and Pattern Recognition · Computer Science 2018-09-13 Heran Yang , Jian Sun , Aaron Carass , Can Zhao , Junghoon Lee , Zongben Xu , Jerry Prince

Purpose A Magnetic Resonance Imaging (MRI) exam typically consists of several sequences that yield different image contrasts. Each sequence is parameterized through multiple acquisition parameters that influence image contrast,…

Image and Video Processing · Electrical Eng. & Systems 2022-02-23 Jonas Denck , Jens Guehring , Andreas Maier , Eva Rothgang

This study aims to develop a novel Cycle-guided Denoising Diffusion Probability Model (CG-DDPM) for cross-modality MRI synthesis. The CG-DDPM deploys two DDPMs that condition each other to generate synthetic images from two different MRI…

Image and Video Processing · Electrical Eng. & Systems 2023-05-02 Shaoyan Pan , Chih-Wei Chang , Junbo Peng , Jiahan Zhang , Richard L. J. Qiu , Tonghe Wang , Justin Roper , Tian Liu , Hui Mao , Xiaofeng Yang

In recent advancements in proton therapy, MR-based treatment planning is gaining momentum to minimize additional radiation exposure compared to traditional CT-based methods. This transition highlights the critical need for accurate MR-to-CT…

Medical Physics · Physics 2024-07-02 Muheng Li , Xia Li , Sairos Safai , Damien Weber , Antony Lomax , Ye Zhang

Purpose: Different Magnetic resonance imaging (MRI) modalities of the same anatomical structure are required to present different pathological information from the physical level for diagnostic needs. However, it is often difficult to…

Image and Video Processing · Electrical Eng. & Systems 2021-09-15 Yuchen Fei , Bo Zhan , Mei Hong , Xi Wu , Jiliu Zhou , Yan Wang

Data scarcity in medical imaging poses significant challenges due to privacy concerns. Diffusion models, a recent generative modeling technique, offer a potential solution by generating synthetic and realistic data. However, questions…

Image and Video Processing · Electrical Eng. & Systems 2024-12-24 Abdullah al Nomaan Nafi , Md. Alamgir Hossain , Rakib Hossain Rifat , Md Mahabub Uz Zaman , Md Manjurul Ahsan , Shivakumar Raman

Synthesizing high-quality images from low-field MRI holds significant potential. Low-field MRI is cheaper, more accessible, and safer, but suffers from low resolution and poor signal-to-noise ratio. This synthesis process can reduce…

Computer Vision and Pattern Recognition · Computer Science 2025-10-16 Zhenxuan Zhang , Peiyuan Jing , Zi Wang , Ula Briski , Coraline Beitone , Yue Yang , Yinzhe Wu , Fanwen Wang , Liutao Yang , Jiahao Huang , Zhifan Gao , Zhaolin Chen , Kh Tohidul Islam , Guang Yang , Peter J. Lally

The ability to synthesise Computed Tomography images - commonly known as pseudo CT, or pCT - from MRI input data is commonly assessed using an intensity-wise similarity, such as an L2-norm between the ground truth CT and the pCT. However,…

Image and Video Processing · Electrical Eng. & Systems 2020-04-15 Kerstin Kläser , Thomas Varsavsky , Pawel Markiewicz , Tom Vercauteren , David Atkinson , Kris Thielemans , Brian Hutton , M Jorge Cardoso , Sebastien Ourselin

Synthetic CT image generation from MRI scan is necessary to create radiotherapy plans without the need of co-registered MRI and CT scans. The chosen baseline adversarial model with cycle consistency permits unpaired image-to-image…

Image and Video Processing · Electrical Eng. & Systems 2023-08-16 Denis Prokopenko , Joël Valentin Stadelmann , Heinrich Schulz , Steffen Renisch , Dmitry V. Dylov

Non-contrast CT (NCCT) imaging may reduce image contrast and anatomical visibility, potentially increasing diagnostic uncertainty. In contrast, contrast-enhanced CT (CECT) facilitates the observation of regions of interest (ROI). Leading…

Image and Video Processing · Electrical Eng. & Systems 2024-11-18 Tingyi Lin , Pengju Lyu , Jie Zhang , Yuqing Wang , Cheng Wang , Jianjun Zhu

Generative AI models hold great potential in creating synthetic brain MRIs that advance neuroimaging studies by, for example, enriching data diversity. However, the mainstay of AI research only focuses on optimizing the visual quality (such…

Image and Video Processing · Electrical Eng. & Systems 2023-10-10 Wei Peng , Tomas Bosschieter , Jiahong Ouyang , Robert Paul , Ehsan Adeli , Qingyu Zhao , Kilian M. Pohl

Generating synthetic CT (sCT) from MRI or CBCT plays a crucial role in enabling MRI-only and CBCT-based adaptive radiotherapy, improving treatment precision while reducing patient radiation exposure. To address this task, we adopt a fully…

Computer Vision and Pattern Recognition · Computer Science 2026-04-24 Arnela Hadzic , Simon Johannes Joham , Martin Urschler