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Recent work by Chatzi et al. and Ravfogel et al. has developed, for the first time, a method for generating counterfactuals of probabilistic Large Language Models. Such counterfactuals tell us what would - or might - have been the output of…

Artificial Intelligence · Computer Science 2026-04-21 Sander Beckers

Rare disease diagnosis is inherently challenging due to heterogeneous symptoms, limited clinical familiarity, and fragmented evidence across specialties. Recent large language model (LLM)-based agentic systems have shown promise by…

Human-Computer Interaction · Computer Science 2026-03-31 Peng Kuai , Yukun Yang , Shaolun Ruan , Junchi Xu , Yanjie Zhang , Lin Zhang , Min Zhu , Rui Sheng

The rise of AI has fueled growing concerns about ``hype'' in machine learning papers, yet a reliable way to quantify rhetorical style independently of substantive content has remained elusive. Because bold language can stem from either…

Computation and Language · Computer Science 2025-12-24 Jingyi Qiu , Hong Chen , Zongyi Li

Evaluating medical AI systems using expert clinician panels is costly and slow, motivating the use of large language models (LLMs) as alternative adjudicators. Here, we evaluate an LLM jury composed of three frontier AI models scoring 3333…

The diagnosis of most mental disorders, including psychiatric evaluations, primarily depends on dialogues between psychiatrists and patients. This subjective process can lead to variability in diagnoses across clinicians and patients,…

Artificial Intelligence · Computer Science 2025-10-30 Eranga Bandara , Ross Gore , Atmaram Yarlagadda , Anita H. Clayton , Preston Samuel , Christopher K. Rhea , Sachin Shetty

Causal discovery is an imperative foundation for decision-making across domains, such as smart health, AI for drug discovery and AIOps. Traditional statistical causal discovery methods, while well-established, predominantly rely on…

Machine Learning · Computer Science 2025-06-03 ChengAo Shen , Zhengzhang Chen , Dongsheng Luo , Dongkuan Xu , Haifeng Chen , Jingchao Ni

We propose a clinical decision support system (CDSS) for mental health diagnosis that combines the strengths of large language models (LLMs) and constraint logic programming (CLP). Having a CDSS is important because of the high complexity…

Artificial Intelligence · Computer Science 2025-02-24 Brian Hyeongseok Kim , Chao Wang

Large language models (LLMs) are gaining increasing interests to improve clinical efficiency for medical diagnosis, owing to their unprecedented performance in modelling natural language. Ensuring the safe and reliable clinical…

Computation and Language · Computer Science 2024-03-26 Lei Liu , Xiaoyan Yang , Fangzhou Li , Chenfei Chi , Yue Shen , Shiwei Lyu Ming Zhang , Xiaowei Ma , Xiangguo Lyu , Liya Ma , Zhiqiang Zhang , Wei Xue , Yiran Huang , Jinjie Gu

Clinical practice in psychiatry is burdened with the increased demand for healthcare services and the scarce resources available. New paradigms of health data powered with machine learning techniques could open the possibility to improve…

Artificial Intelligence · Computer Science 2023-06-08 Juan Sebastian Canas , Francisco Gomez , Omar Costilla-Reyes

Emergency departments worldwide face rising patient volumes, workforce shortages, and variability in triage decisions that threaten the delivery of timely and accurate care. Current triage methods rely primarily on vital signs, routine…

Quantitative Methods · Quantitative Biology 2025-10-21 Kerem Delikoyun , Qianyu Chen , Win Sen Kuan , John Tshon Yit Soong , Matthew Edward Cove , Oliver Hayden

Medical imaging has revolutionized diagnosis, yet unnecessary procedures are rising, exposing patients to radiation and stress, limiting equitable access, and straining healthcare systems. The American College of Radiology Appropriateness…

Quantitative Methods · Quantitative Biology 2025-10-08 Anni Tziakouri , Filippo Menolascina

Large language models (LLMs) remain unreliable for high-stakes claim verification due to hallucinations and shallow reasoning. While retrieval-augmented generation (RAG) and multi-agent debate (MAD) address this, they are limited by…

Computation and Language · Computer Science 2026-05-13 Masnun Nuha Chowdhury , Nusrat Jahan Beg , Umme Hunny Khan , Syed Rifat Raiyan , Md Kamrul Hasan , Hasan Mahmud

LLM-based agents have emerged as transformative tools capable of executing complex tasks through iterative planning and action, achieving significant advancements in understanding and addressing user needs. Yet, their effectiveness remains…

Human-Computer Interaction · Computer Science 2025-08-26 Mithat Can Ozgun , Jiahuan Pei , Koen Hindriks , Lucia Donatelli , Qingzhi Liu , Junxiao Wang

Conversational diagnosis requires multi-turn history-taking, where an agent asks clarifying questions to refine differential diagnoses under incomplete information. Existing approaches often rely on the parametric knowledge of a model or…

Artificial Intelligence · Computer Science 2026-02-04 Jeongmoon Won , Seungwon Kook , Yohan Jo

Artificial intelligence has significantly advanced healthcare, particularly through large language models (LLMs) that excel in medical question answering benchmarks. However, their real-world clinical application remains limited due to the…

Computation and Language · Computer Science 2024-07-01 Zhihao Fan , Jialong Tang , Wei Chen , Siyuan Wang , Zhongyu Wei , Jun Xi , Fei Huang , Jingren Zhou

A decade of rapid advances in artificial intelligence (AI) has opened new opportunities for clinical decision support systems (CDSS), with large language models (LLMs) demonstrating strong reasoning abilities on timely medical tasks.…

Computation and Language · Computer Science 2025-11-25 Heejoon Koo

As the field of healthcare increasingly adopts artificial intelligence, it becomes important to understand which types of explanations increase transparency and empower users to develop confidence and trust in the predictions made by…

Artificial Intelligence · Computer Science 2025-05-16 Felix Liedeker , Olivia Sanchez-Graillet , Moana Seidler , Christian Brandt , Jörg Wellmer , Philipp Cimiano

While current Automated Essay Scoring (AES) methods demonstrate high scoring agreement with human raters, their decision-making mechanisms are not fully understood. Our proposed method, using counterfactual intervention assisted by Large…

Computation and Language · Computer Science 2024-10-10 Yupei Wang , Renfen Hu , Zhe Zhao

Large Language Models (LLMs) are increasingly used for clinical decision support, where hallucinations and unsafe suggestions may pose direct risks to patient safety. These risks are hard to assess: subtle clinical errors are often missed…

Computation and Language · Computer Science 2026-05-14 Yinzhu Chen , Abdine Maiga , Hossein A. Rahmani , Emine Yilmaz

Large Language Models (LLMs) are increasingly deployed for clinical reasoning tasks, which inherently require eliciting calibrated probabilistic beliefs based on available evidence. However, real-world clinical data are frequently…

Artificial Intelligence · Computer Science 2026-03-19 Yuta Kobayashi , Vincent Jeanselme , Shalmali Joshi