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Recent advancements in Large Language Models (LLMs) have positioned them as powerful tools for clinical decision-making, with rapidly expanding applications in healthcare. However, concerns about bias remain a significant challenge in the…

Artificial Intelligence · Computer Science 2024-10-23 Kenza Benkirane , Jackie Kay , Maria Perez-Ortiz

Causal explanations of the predictions of NLP systems are essential to ensure safety and establish trust. Yet, existing methods often fall short of explaining model predictions effectively or efficiently and are often model-specific. In…

Computation and Language · Computer Science 2023-11-23 Yair Gat , Nitay Calderon , Amir Feder , Alexander Chapanin , Amit Sharma , Roi Reichart

Verification of biomedical claims is critical for healthcare decision-making, public health policy and scientific research. We present an interactive biomedical claim verification system by integrating LLMs, transparent model explanations,…

Human-Computer Interaction · Computer Science 2025-03-03 Siting Liang , Daniel Sonntag

Large language models (LLMs) have demonstrated remarkable capabilities in language generation, understanding, and few-shot learning in recent years. An extensive body of work has explored how their performance may be further improved…

Computation and Language · Computer Science 2023-05-24 Yilun Du , Shuang Li , Antonio Torralba , Joshua B. Tenenbaum , Igor Mordatch

Counterfactual reasoning has emerged as a crucial technique for generalizing the reasoning capabilities of large language models (LLMs). By generating and analyzing counterfactual scenarios, researchers can assess the adaptability and…

Artificial Intelligence · Computer Science 2026-02-17 Shuai Yang , Qi Yang , Luoxi Tang , Yuqiao Meng , Nancy Guo , Jeremy Blackburn , Zhaohan Xi

The growing integration of machine learning (ML) and artificial intelligence (AI) models into high-stakes domains such as healthcare and scientific research calls for models that are not only accurate but also interpretable. Among the…

Machine Learning · Computer Science 2025-10-23 Zhuo Cao , Xuan Zhao , Lena Krieger , Hanno Scharr , Ira Assent

Estimating individualized treatment effects from observational data presents a persistent challenge due to unmeasured confounding and structural bias. Causal Machine Learning (causal ML) methods, such as causal trees and doubly robust…

Machine Learning · Computer Science 2025-08-12 Po-Han Lee , Yu-Cheng Lin , Chan-Tung Ku , Chan Hsu , Pei-Cing Huang , Ping-Hsun Wu , Yihuang Kang

Large Language Models (LLMs) have shown remarkable capabilities in general natural language processing tasks but often fall short in complex reasoning tasks. Recent studies have explored human-like problem-solving strategies, such as…

Computation and Language · Computer Science 2023-12-19 Zhenran Xu , Senbao Shi , Baotian Hu , Jindi Yu , Dongfang Li , Min Zhang , Yuxiang Wu

Recent advances in large language models (LLMs) have shown promising results in medical diagnosis, with some studies indicating superior performance compared to human physicians in specific scenarios. However, the diagnostic capabilities of…

Artificial Intelligence · Computer Science 2025-03-24 Zhoujian Sun , Ziyi Liu , Cheng Luo , Jiebin Chu , Zhengxing Huang

Machine learning (ML) systems for medical imaging have demonstrated remarkable diagnostic capabilities, but their susceptibility to biases poses significant risks, since biases may negatively impact generalization performance. In this…

Machine Learning · Computer Science 2025-04-29 Haroui Ma , Francesco Quinzan , Theresa Willem , Stefan Bauer

Multimodal clinical reasoning in the field of gastrointestinal (GI) oncology necessitates the integrated interpretation of endoscopic imagery, radiological data, and biochemical markers. Despite the evident potential exhibited by Multimodal…

Large language models (LLMs) have shown promise in medical domains, but their ability to handle specialized neurological reasoning requires systematic evaluation. We developed a comprehensive benchmark using 305 questions from Israeli Board…

Information Retrieval · Computer Science 2025-08-21 Moran Sorka , Alon Gorenshtein , Dvir Aran , Shahar Shelly

Large Language Models (LLMs) can produce verbalized self-explanations, yet prior studies suggest that such rationales may not reliably reflect the model's true decision process. We ask whether these explanations nevertheless help users…

Computation and Language · Computer Science 2026-01-08 Pingjun Hong , Benjamin Roth

The development of large language models (LLMs) has brought unprecedented possibilities for artificial intelligence (AI) based medical diagnosis. However, the application perspective of LLMs in real diagnostic scenarios is still unclear…

Computation and Language · Computer Science 2024-05-21 Zhoujian Sun , Cheng Luo , Ziyi Liu , Zhengxing Huang

Clinical dialogue represents a complex duality requiring both the empathetic fluency of natural conversation and the rigorous precision of evidence-based medicine. While Large Language Models possess unprecedented linguistic capabilities,…

Other Quantitative Biology · Quantitative Biology 2025-12-02 Xiaoquan Zhi , Hongke Zhao , Likang Wu , Chuang Zhao , Hengshu Zhu

The reliance of text classifiers on spurious correlations can lead to poor generalization at deployment, raising concerns about their use in safety-critical domains such as healthcare. In this work, we propose to use counterfactual data…

Machine Learning · Computer Science 2024-01-10 Amir Feder , Yoav Wald , Claudia Shi , Suchi Saria , David Blei

Matching patients effectively and efficiently for clinical trials is a significant challenge due to the complexity and variability of patient profiles and trial criteria. This paper introduces \textbf{Multi-Agent for Knowledge Augmentation…

Multiagent Systems · Computer Science 2026-05-19 Hanwen Shi , Jin Zhang , Kunpeng Zhang

Large language models (LLMs) have demonstrated strong potential in clinical question answering, with recent multi-agent frameworks further improving diagnostic accuracy via collaborative reasoning. However, we identify a recurring issue of…

Computation and Language · Computer Science 2025-05-28 Yihan Wang , Qiao Yan , Zhenghao Xing , Lihao Liu , Junjun He , Chi-Wing Fu , Xiaowei Hu , Pheng-Ann Heng

Large language models (LLMs) are increasingly envisioned as decision-support tools in clinical practice, yet safe clinical reasoning demands integrating heterogeneous knowledge bases -- trials, primary studies, regulatory documents, and…

Computation and Language · Computer Science 2025-05-22 Shan Chen , Pedro Moreira , Yuxin Xiao , Sam Schmidgall , Jeremy Warner , Hugo Aerts , Thomas Hartvigsen , Jack Gallifant , Danielle S. Bitterman

Causality is vital for understanding true cause-and-effect relationships between variables within predictive models, rather than relying on mere correlations, making it highly relevant in the field of Explainable AI. In an automated…

Machine Learning · Computer Science 2024-08-28 Arturo Fredes , Jordi Vitria