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Automatic diagnosis is a significant application of AI in healthcare, where diagnoses are generated based on the symptom description of patients. Previous works have approached this task directly by modeling the relationship between the…

Computation and Language · Computer Science 2024-01-30 Haochun Wang , Sendong Zhao , Zewen Qiang , Nuwa Xi , Bing Qin , Ting Liu

Large Language Models (LLMs) show promise in biomedicine but lack true causal understanding, relying instead on correlations. This paper envisions causal LLM agents that integrate multimodal data (text, images, genomics, etc.) and perform…

Artificial Intelligence · Computer Science 2025-05-23 Adib Bazgir , Amir Habibdoust Lafmajani , Yuwen Zhang

Multimodal artificial intelligence (AI) systems have the potential to enhance clinical decision-making by interpreting various types of medical data. However, the effectiveness of these models across all medical fields is uncertain. Each…

Counterfactuals refer to minimally edited inputs that cause a model's prediction to change, serving as a promising approach to explaining the model's behavior. Large language models (LLMs) excel at generating English counterfactuals and…

Computation and Language · Computer Science 2026-04-07 Qianli Wang , Van Bach Nguyen , Yihong Liu , Fedor Splitt , Nils Feldhus , Christin Seifert , Hinrich Schütze , Sebastian Möller , Vera Schmitt

Large language models (LLMs) are increasingly deployed in clinical decision support, yet subtle demographic cues can influence their reasoning. Prior work has documented disparities in outputs across patient groups, but little is known…

Computation and Language · Computer Science 2025-10-16 Rajarshi Ghosh , Abhay Gupta , Hudson McBride , Anurag Vaidya , Faisal Mahmood

Large language models (LLMs) have demonstrated notable potential in medical applications, yet they face substantial challenges in handling complex real-world clinical diagnoses using conventional prompting methods. Current prompt…

Artificial Intelligence · Computer Science 2026-03-02 Wenliang Li , Rui Yan , Xu Zhang , Li Chen , Hongji Zhu , Jing Zhao , Junjun Li , Mengru Li , Wei Cao , Zihang Jiang , Wei Wei , Kun Zhang , Shaohua Kevin Zhou

Clinical Decision Support Systems (CDSS) utilize evidence-based knowledge and patient data to offer real-time recommendations, with Large Language Models (LLMs) emerging as a promising tool to generate plain-text explanations for medical…

Computation and Language · Computer Science 2023-10-04 D. Umerenkov , G. Zubkova , A. Nesterov

Medical diagnosis prediction plays a critical role in disease detection and personalized healthcare. While machine learning (ML) models have been widely adopted for this task, their reliance on supervised training limits their ability to…

Artificial Intelligence · Computer Science 2025-07-08 Yuzhang Xie , Hejie Cui , Ziyang Zhang , Jiaying Lu , Kai Shu , Fadi Nahab , Xiao Hu , Carl Yang

Clinical Decision Support Systems (CDSSs) provide reasoning and inquiry guidance for physicians, yet they face notable challenges, including high maintenance costs and low generalization capability. Recently, Large Language Models (LLMs)…

Computation and Language · Computer Science 2026-04-24 Yue Guo , Fanfu Wang , Jianwei Lv , Xincheng Shi , Yuchen Li , Youya Wang , Yunsheng Zeng , Yujing Liu , Yunhao Qiao , Gen Li , Junfeng Wang , Bo Yuan

Despite achieving high accuracy on medical benchmarks, LLMs exhibit the Einstellung Effect in clinical diagnosis--relying on statistical shortcuts rather than patient-specific evidence, causing misdiagnosis in atypical cases. Existing…

Computation and Language · Computer Science 2026-01-13 Wenting Chen , Zhongrui Zhu , Guolin Huang , Wenxuan Wang

Clinical decision-making requires reasoning over incomplete, imprecise, and linguistically expressed patient narratives. While large language models (LLMs) excel at extracting latent information from natural language, they lack the…

Artificial Intelligence · Computer Science 2026-05-26 Xiaoyang Fan , Yufan Cai , Zhe Hou , Jin Song Dong

Large language models (LLMs) have shown considerable potential in supporting medical diagnosis. However, their effective integration into clinical workflows is hindered by physicians' difficulties in perceiving and trusting LLM…

Human-Computer Interaction · Computer Science 2026-01-28 Yuansong Xu , Yichao Zhu , Haokai Wang , Yuchen Wu , Yang Ouyang , Hanlu Li , Wenzhe Zhou , Xinyu Liu , Chang Jiang , Quan Li

Clinical diagnosis begins with doctor-patient interaction, during which physicians iteratively gather information, determine examination and refine differential diagnosis through patients' response. This dynamic clinical-reasoning process…

Computation and Language · Computer Science 2025-12-30 Yuqi Tang , Jing Yu , Zichang Su , Kehua Feng , Zhihui Zhu , Libin Wang , Lei Liang , Qiang Zhang , Keyan Ding , Huajun Chen

Artificial intelligence (AI) has demonstrated strong potential in clinical diagnostics, often achieving accuracy comparable to or exceeding that of human experts. A key challenge, however, is that AI reasoning frequently diverges from…

Artificial Intelligence · Computer Science 2026-05-25 Belona Sonna , Alban Grastien

The proliferation of Large Language Models (LLMs) in medicine has enabled impressive capabilities, yet a critical gap remains in their ability to perform systematic, transparent, and verifiable reasoning, a cornerstone of clinical practice.…

Computation and Language · Computer Science 2025-08-04 Wenxuan Wang , Zizhan Ma , Meidan Ding , Shiyi Zheng , Shengyuan Liu , Jie Liu , Jiaming Ji , Wenting Chen , Xiang Li , Linlin Shen , Yixuan Yuan

Large language models (LLMs) are entering clinician workflows, yet evaluations rarely measure how clinician reasoning shapes model behavior during clinical interactions. We combined 61 New England Journal of Medicine Case Records with 92…

With the rise of Large Language Models(LLMs), it has become crucial to understand their capabilities and limitations in deciphering and explaining the complex web of causal relationships that language entails. Current methods use either…

Clinical decision-making requires nuanced reasoning over heterogeneous evidence and traceable justifications. While recent LLM multi-agent systems (MAS) show promise, they largely optimise for outcome accuracy while overlooking…

Artificial Intelligence · Computer Science 2026-02-17 Chaeeun Lee , T. Michael Yates , Pasquale Minervini , T. Ian Simpson

Hallucination continues to pose a major obstacle in the reasoning capabilities of large language models (LLMs). Although the Multi-Agent Debate (MAD) paradigm offers a promising solution by promoting consensus among multiple agents to…

Artificial Intelligence · Computer Science 2025-11-17 Dayong Liang , Xiao-Yong Wei , Changmeng Zheng

In modern medicine, clinical diagnosis relies on the comprehensive analysis of primarily textual and visual data, drawing on medical expertise to ensure systematic and rigorous reasoning. Recent advances in large Vision-Language Models…

Artificial Intelligence · Computer Science 2025-07-03 Ziyue Wang , Junde Wu , Linghan Cai , Chang Han Low , Xihong Yang , Qiaxuan Li , Yueming Jin