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Large reasoning models excel in domains like mathematics where intermediate reasoning is straightforward to verify, but struggle to self-correct in medicine fields where evaluating intermediate reasoning is cumbersome and expensive. This…

Artificial Intelligence · Computer Science 2026-02-26 Zongxian Yang , Jiayu Qian , Zegao Peng , Haoyu Zhang , Yu-An Huang , KC Tan , Zhi-An Huang

Clinical reasoning in medicine is a hypothesis-driven process where physicians refine diagnoses from limited information through targeted history, physical examination, and diagnostic investigations. In contrast, current medical benchmarks…

Machine Learning · Computer Science 2025-10-14 Christopher Chiu , Silviu Pitis , Mihaela van der Schaar

Reasoning Large Language Models (LLMs) with enhanced accuracy and explainability are increasingly being adopted in the medical domain, as the life-critical nature of clinical decision-making demands reliable support. Despite these…

Computation and Language · Computer Science 2025-11-12 Sung-Min Lee , Siyoon Lee , Juyeon Kim , Kyoungmin Roh

Retrieval-augmented generation (RAG) improves large language models (LLMs) by incorporating external evidence, but it also introduces knowledge conflicts when retrieved contextual knowledge (CK) and parametric knowledge (PK) disagree or are…

Information Retrieval · Computer Science 2026-05-20 Xi Zhu , Ziqi Wang , Kai Mei , Wujiang Xu , Minghao Guo , Bangji Yang , Jiajun Fan , Dimitris N. Metaxas

Retrieval plays a central role in multi-hop question answering (QA), where answering complex questions requires gathering multiple pieces of evidence. We introduce an Agentic Retrieval System that leverages large language models (LLMs) in a…

Computation and Language · Computer Science 2025-10-17 Md Mahadi Hasan Nahid , Davood Rafiei

Personalization in Question Answering (QA) requires answers that are both accurate and aligned with users' background, preferences, and historical context. Existing state-of-the-art methods primarily rely on retrieval-augmented generation…

Computation and Language · Computer Science 2026-02-24 Maryam Amirizaniani , Alireza Salemi , Hamed Zamani

Terminology substitution errors in clinical notes, where one medical term is replaced by a linguistically valid but clinically different term, pose a persistent challenge for automated error detection in healthcare. We introduce BLUEmed, a…

Computation and Language · Computer Science 2026-04-14 Saukun Thika You , Nguyen Anh Khoa Tran , Wesley K. Marizane , Hanshu Rao , Qiunan Zhang , Xiaolei Huang

Large language models have shown promise in clinical decision making, but current approaches struggle to localize and correct errors at specific steps of the reasoning process. This limitation is critical in medicine, where identifying and…

Large language models face challenges in long-context question answering, where key evidence of a query may be dispersed across millions of tokens. Existing works equip large language models with a memory buffer that is dynamically updated…

Computation and Language · Computer Science 2026-03-03 Yaorui Shi , Yuxin Chen , Siyuan Wang , Sihang Li , Hengxing Cai , Qi Gu , Xiang Wang , An Zhang

Pre-trained multimodal models have achieved significant success in retrieval-based question answering. However, current multimodal retrieval question-answering models face two main challenges. Firstly, utilizing compressed evidence features…

Artificial Intelligence · Computer Science 2023-10-17 Shuwen Yang , Anran Wu , Xingjiao Wu , Luwei Xiao , Tianlong Ma , Cheng Jin , Liang He

The Retrieval-Augmented Language Model (RALM) has shown remarkable performance on knowledge-intensive tasks by incorporating external knowledge during inference, which mitigates the factual hallucinations inherited in large language models…

Computation and Language · Computer Science 2024-12-20 Yuan Xia , Jingbo Zhou , Zhenhui Shi , Jun Chen , Haifeng Huang

Biomedical retrieval-augmented generation (RAG) can ground LLM answers in medical literature, yet long-form outputs often contain isolated unsupported or contradictory claims with safety implications. We introduce MedRAGChecker, a…

Computation and Language · Computer Science 2026-01-13 Yuelyu Ji , Min Gu Kwak , Hang Zhang , Xizhi Wu , Chenyu Li , Yanshan Wang

Agentic Retrieval Augmented Generation (RAG) and 'deep research' systems aim to enable autonomous search processes where Large Language Models (LLMs) iteratively refine outputs. However, applying these systems to domain-specific…

Computation and Language · Computer Science 2025-08-08 Samy Ateia , Udo Kruschwitz

Retrieval-Augmented Generation (RAG) grounds Large Language Models (LLMs) in external knowledge but often suffers from flat context representations and stateless retrieval, leading to unstable performance. We propose Stateful…

Computation and Language · Computer Science 2026-04-17 Qi Dong , Ziheng Lin , Ning Ding

Retrieval-augmented generation combined with reinforcement learning has shown promise for grounding large language models in trustworthy medical evidence. However, existing methods rely on exact-match binary rewards, which in clinical…

Artificial Intelligence · Computer Science 2026-05-28 Yuwei Miao , Gen Li , Yunsheng Zeng , Xiandong Li , Yujin Wang , Siyu Chen , Luning Wang , Yunhao Qiao , Junfeng Wang , Jianwei Lv , Bo Yuan

Evaluating large language models (LLMs) in the biomedical domain requires benchmarks that can distinguish reasoning from pattern matching and remain discriminative as model capabilities improve. Existing biomedical question answering (QA)…

This paper presents the development and evaluation of a Retrieval-Augmented Generation (RAG) system for querying the United Kingdom's National Institute for Health and Care Excellence (NICE) clinical guidelines using Large Language Models…

Large Reasoning Models (LRMs) exhibit remarkable reasoning abilities but rely primarily on parametric knowledge, limiting factual accuracy. While recent works equip reinforcement learning (RL)-based LRMs with retrieval capabilities, they…

Computation and Language · Computer Science 2025-05-20 Zhicheng Lee , Shulin Cao , Jinxin Liu , Jiajie Zhang , Weichuan Liu , Xiaoyin Che , Lei Hou , Juanzi Li

Access to the right evidence does not guarantee that large language models (LLMs) will reason with it correctly. This gap between retrieval and reasoning is especially concerning in clinical settings, where outputs must align with…

Artificial Intelligence · Computer Science 2025-11-21 Deepthi Potluri , Aby Mammen Mathew , Jeffrey B DeWitt , Alexander L. Rasgon , Yide Hao , Junyuan Hong , Ying Ding

Question answering is a task that answers factoid questions using a large collection of documents. It aims to provide precise answers in response to the user's questions in natural language. Question answering relies on efficient passage…

Computation and Language · Computer Science 2023-08-09 Shashank Gupta