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Related papers: PubMed Reasoner: Dynamic Reasoning-based Retrieval…

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Large language models (LLM) hold significant potential for applications in biomedicine, but they struggle with hallucinations and outdated knowledge. While retrieval-augmented generation (RAG) is generally employed to address these issues,…

Computation and Language · Computer Science 2025-09-23 Jiwoong Sohn , Yein Park , Chanwoong Yoon , Sihyeon Park , Hyeon Hwang , Mujeen Sung , Hyunjae Kim , Jaewoo Kang

The emergent abilities of large language models (LLMs) have demonstrated great potential in solving medical questions. They can possess considerable medical knowledge, but may still hallucinate and are inflexible in the knowledge updates.…

Computation and Language · Computer Science 2024-10-14 Guangzhi Xiong , Qiao Jin , Xiao Wang , Minjia Zhang , Zhiyong Lu , Aidong Zhang

Medical tasks such as diagnosis and treatment planning require precise and complex reasoning, particularly in life-critical domains. Unlike mathematical reasoning, medical reasoning demands meticulous, verifiable thought processes to ensure…

Computation and Language · Computer Science 2025-04-08 Juncheng Wu , Wenlong Deng , Xingxuan Li , Sheng Liu , Taomian Mi , Yifan Peng , Ziyang Xu , Yi Liu , Hyunjin Cho , Chang-In Choi , Yihan Cao , Hui Ren , Xiang Li , Xiaoxiao Li , Yuyin Zhou

We introduce PubMedQA, a novel biomedical question answering (QA) dataset collected from PubMed abstracts. The task of PubMedQA is to answer research questions with yes/no/maybe (e.g.: Do preoperative statins reduce atrial fibrillation…

Computation and Language · Computer Science 2019-09-16 Qiao Jin , Bhuwan Dhingra , Zhengping Liu , William W. Cohen , Xinghua Lu

Medical question answering (QA) requires extensive access to domain-specific knowledge. A promising direction is to enhance large language models (LLMs) with external knowledge retrieved from medical corpora or parametric knowledge stored…

Computation and Language · Computer Science 2025-10-22 Lei Li , Xiao Zhou , Yingying Zhang , Xian Wu

Large Language Models (LLMs) with reasoning capabilities have recently demonstrated strong potential in medical Question Answering (QA). Existing approaches are largely English-focused and primarily rely on distillation from general-purpose…

Computation and Language · Computer Science 2026-03-31 Pietro Ferrazzi , Aitor Soroa , Rodrigo Agerri

Large language models (LLMs) are transforming the landscape of medicine, yet two fundamental challenges persist: keeping up with rapidly evolving medical knowledge and providing verifiable, evidence-grounded reasoning. Retrieval-augmented…

Assessing the veracity of online content has become increasingly critical. Large language models (LLMs) have recently enabled substantial progress in automated veracity assessment, including automated fact-checking and claim verification…

Computation and Language · Computer Science 2026-04-14 Yupeng Cao , Chengyang He , Yangyang Yu , Ping Wang , K. P. Subbalakshmi

As LLM-driven autonomous agents evolve to perform complex, multi-step tasks that require integrating multiple datasets, the problem of discovering relevant data sources becomes a key bottleneck. Beyond the challenge posed by the sheer…

Databases · Computer Science 2026-04-23 Jiani Zhang , Sercan O. Arik , Cosmin Arad , Fatma Ozcan , Alon Halevy

Retrieval-Augmented Generation (RAG) systems for Large Language Models (LLMs) hold promise in knowledge-intensive tasks but face limitations in complex multi-step reasoning. While recent methods have integrated RAG with chain-of-thought…

Computation and Language · Computer Science 2025-01-15 Zhongxiang Sun , Qipeng Wang , Weijie Yu , Xiaoxue Zang , Kai Zheng , Jun Xu , Xiao Zhang , Song Yang , Han Li

Predicting future clinical outcomes from electronic health records (EHR) remains challenging due to the complexity and heterogeneity of patient data. LLMs have shown strong potential for such predictive tasks, yet existing approaches mainly…

Computation and Language · Computer Science 2026-05-05 Yushi Cao , Yiming Chen , Hongchao Jiang , Hung-yi Lee , Robby T. Tan

Professional domain knowledge underpins human civilization, serving as both the basis for industry entry and the core of complex decision-making and problem-solving. However, existing large language models often suffer from opaque inference…

Computation and Language · Computer Science 2026-04-30 Xudong Wang , Zilong Wang , Zhaoyan Ming

Knowledge graphs and large language models (LLMs) are key tools for biomedical knowledge integration and reasoning, facilitating structured organization of scientific articles and discovery of complex semantic relationships. However,…

Computation and Language · Computer Science 2025-04-01 Yichun Feng , Jiawei Wang , Ruikun He , Lu Zhou , Yixue Li

Automated question-answering (QA) systems increasingly rely on retrieval-augmented generation (RAG) to ground large language models (LLMs) in authoritative medical knowledge, ensuring clinical accuracy and patient safety in Artificial…

Computation and Language · Computer Science 2026-03-05 Aswini Sivakumar , Vijayan Sugumaran , Yao Qiang

Retrieval-augmented generation has achieved strong performance on knowledge-intensive tasks where query-document relevance can be identified through direct lexical or semantic matches. However, many real-world queries involve abstract…

Information Retrieval · Computer Science 2026-04-03 Duolin Sun , Meixiu Long , Dan Yang , Junjie Wang , Yecheng Luo , Yue Shen , Jian Wang , Hualei Zhou , Chunxiao Guo , Peng Wei , Jiahai Wang , Jinjie Gu

Retrieval-Augmented Generation (RAG) is a powerful technique for enriching Large Language Models (LLMs) with external knowledge, allowing for factually grounded responses, a critical requirement in high-stakes domains such as healthcare.…

Computation and Language · Computer Science 2025-10-07 Eduardo Martínez Rivera , Filippo Menolascina

The integration of Large Language Models (LLMs) into healthcare is constrained by knowledge limitations, hallucinations, and a disconnect from Evidence-Based Medicine (EBM). While Retrieval-Augmented Generation (RAG) offers a solution,…

Computation and Language · Computer Science 2026-02-03 Qiaoyu Zheng , Yuze Sun , Chaoyi Wu , Weike Zhao , Pengcheng Qiu , Yongguo Yu , Kun Sun , Jian Zhang , Yanfeng Wang , Ya Zhang , Weidi Xie

While large language models show promise in medical applications, achieving expert-level clinical reasoning remains challenging due to the need for both accurate answers and transparent reasoning processes. To address this challenge, we…

Machine Learning · Computer Science 2025-09-22 Chi Liu , Derek Li , Yan Shu , Robin Chen , Derek Duan , Teng Fang , Bryan Dai

Biomedical Question Answering systems play a critical role in processing complex medical queries, yet they often struggle with the intricate nature of medical data and the demand for multi-hop reasoning. In this paper, we propose a model…

Computation and Language · Computer Science 2026-01-13 Quoc-An Nguyen , Thi-Minh-Thu Vu , Bich-Dat Nguyen , Dinh-Quang-Minh Tran , Hoang-Quynh Le

Biomedical question answering often requires decisions from retrieved literature whose relevance, quality, and support for candidate answers are uneven. Most retrieval-augmented large language model (LLM) methods feed this literature to the…

Computation and Language · Computer Science 2026-05-19 Chang Zong , Hao Ning , Siliang Tang , Jie Huang , Jian Wan