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Parkinson's disease (PD) presents a growing global challenge, affecting over 10 million individuals, with prevalence expected to double by 2040. Early diagnosis remains difficult due to the late emergence of motor symptoms and limitations…

Machine Learning · Computer Science 2025-10-21 Arianna Francesconi , Donato Cappetta , Fabio Rebecchi , Paolo Soda , Valerio Guarrasi , Rosa Sicilia

In the noisy intermediate-scale quantum (NISQ) era, quantum error mitigation (QEM) is essential for producing reliable outputs from quantum circuits. We present a statistical signal processing approach to QEM that estimates the most likely…

Quantitative Magnetic Resonance Imaging (qMRI) provides researchers insight into pathological and physiological alterations of living tissue, with the help of which researchers hope to predict (local) therapeutic efficacy early and…

Applications · Statistics 2008-07-30 Xiaoxi Zhang , Timothy D. Johnson , Roderick J. A. Little , Yue Cao

Parkinson disease (PD)'s speech recognition is an effective way for its diagnosis, which has become a hot and difficult research area in recent years. As we know, there are large corpuses (segments) within one subject. However, too large…

Sound · Computer Science 2021-11-18 Yiwen Wang , Fan Li , Xiaoheng Zhang , Pin Wang , Yongming Li

Introduction: Identifying neurobiological differences between patients suffering from Major Depressive Disorder (MDD) and healthy individuals has been a mainstay of clinical neuroscience for decades. However, recent meta- and mega-analyses…

In this paper, we analyze 48 signals of rest tremor velocity related to 12 distinct subjects affected by Parkinson's disease. The subjects belong to two different groups, formed by four and eight subjects with, respectively, high- and…

Medical Physics · Physics 2016-01-08 Lorenzo Livi , Alireza Sadeghian , Hamid Sadeghian

We study the signatures of quantum integrability (QI) in a spin chain model, having infinite-range Ising interaction and subjected to a periodic pulse of an external magnetic field. We analyze the unitary operator, its eigensystem, the…

Quantum Physics · Physics 2025-09-25 Harshit Sharma , Sashmita Rout , Avadhut V. Purohit , Udaysinh T. Bhosale

Parkinsons disease, the fastest growing neurodegenerative disorder globally, has seen a 50 percent increase in cases within just two years. As speech, memory, and motor symptoms worsen over time, early diagnosis is crucial for preserving…

Quantitative Methods · Quantitative Biology 2024-12-02 Diya Vatsavai , Anya Iyer , Ashwin A. Nair

Neuronal correlates of Parkinson's disease (PD) include a slowing of the electroencephalogram (EEG) and enhanced synchrony at 3-7 and 7-30 Hz in the basal ganglia, thalamus, and cortex. This study describes the dynamics of a physiologically…

Neurons and Cognition · Quantitative Biology 2018-01-08 Sacha Jennifer van Albada , Richard T. Gray , Peter M. Drysdale , Peter A. Robinson

This study investigates EEG as a potential early biomarker by applying deep learning techniques to resting-state EEG recordings from 31 subjects (15 with PD and 16 healthy controls). EEG signals underwent preprocessing to remove tremor…

Neurons and Cognition · Quantitative Biology 2025-03-25 Artem Lensky

Parkinsons Disease (PD) is a neurodegenerative disorder resulting in motor deficits due to advancing degeneration of dopaminergic neurons. PD patients report experiencing tremor, rigidity, visual impairment, bradykinesia, and several…

Computer Vision and Pattern Recognition · Computer Science 2023-04-05 Krish Desai

Uncertainty quantification (UQ) is essential for deploying machine learning models in safety-critical physical systems, yet classical Bayesian approaches incur substantial computational overhead. We establish a formal connection between…

The potential of deep learning in clinical speech processing is immense, yet the hurdles of limited and imbalanced clinical data samples loom large. This article addresses these challenges by showcasing the utilization of automatic speech…

Deep Brain Stimulation (DBS) is a highly effective treatment for Parkinson's Disease (PD). Recent research uses reinforcement learning (RL) for DBS, with RL agents modulating the stimulation frequency and amplitude. But, these models rely…

Machine Learning · Computer Science 2025-10-07 Nicholas Carter , Arkaprava Gupta , Prateek Ganguli , Benedikt Dietrich , Vibhor Krishna , Samarjit Chakraborty

Parkinsons disease (PD) is considered one of the most frequent neurological diseases in the world. There is a need to study the early and efficient biomarkers of Parkinsons, such as changes in structural disorders like DNA and chromatin,…

Parkinson's disease (PD) belongs to the class of neurodegenerative disorders that affect the central nervous system. It is usually defined as the gradual loss of dopaminergic neurons in the substantia nigra pars compacta, which causes both…

Neurons and Cognition · Quantitative Biology 2024-11-01 Hina Shaheen , Roderick Melnik

Structural magnetic resonance imaging (MRI) can be used to detect lesions in the brains of multiple sclerosis (MS) patients. The formation of these lesions is a complex process involving inflammation, tissue damage, and tissue repair, all…

The study of quasi-periodic oscillations (QPOs) and power density spectra (PDS) continuum properties can help shed light on the still illusive emission physics of magnetars and as a window into the interiors of neutron stars using…

We studied the statistical properties of a quantum system in the pseudo-integrable regime through the gap ratios between consecutive energy levels of the scattering spectra. A two-dimensional quantum billiard containing a point-like…

Quantum Physics · Physics 2025-05-23 Afshin Akhshani , Małgorzata Białous , Leszek Sirko

The overparameterization of variational quantum circuits, as a model of Quantum Neural Networks (QNN), not only improves their trainability but also serves as a method for evaluating the property of a given ansatz by investigating their…

Quantum Physics · Physics 2023-05-23 Ali Rad