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Clinical translation of quantitative imaging (QI) methods requires objective evaluation of these methods on reliably measuring the underlying true quantitative values. Ideally, such evaluation would be performed using ground truth or gold…

Medical Physics · Physics 2026-03-31 Yan Liu , Abhinav K. Jha

Objective evaluation of quantitative imaging (QI) methods with patient data, while important, is typically hindered by the lack of gold standards. To address this challenge, no-gold-standard evaluation (NGSE) techniques have been proposed.…

Medical Physics · Physics 2024-03-26 Yan Liu , Abhinav K. Jha

Objective evaluation of quantitative imaging (QI) methods using measurements directly obtained from patient images is highly desirable but hindered by the non-availability of gold standards. To address this issue, statistical techniques…

Methodology · Statistics 2020-06-04 Jinxin Liu , Ziping Liu , Joyce Mhlanga , Barry A. Siegel , Abhinav K. Jha

Quantitative imaging (QI) is demonstrating strong promise across multiple clinical applications. For clinical translation of QI methods, objective evaluation on clinically relevant tasks is essential. To address this need, multiple…

Objective evaluation of quantitative imaging (QI) methods with patient data is highly desirable, but is hindered by the lack or unreliability of an available gold standard. To address this issue, techniques that can evaluate QI methods…

Medical Physics · Physics 2022-03-07 Ziping Liu , Zekun Li , Joyce C. Mhlanga , Barry A. Siegel , Abhinav K. Jha

We present a generic method for assessing the quality of non-rigid registration (NRR) algorithms, that does not depend on the existence of any ground truth, but depends solely on the data itself. The data is a set of images. The output of…

Computer Vision and Pattern Recognition · Computer Science 2020-02-26 Carole J. Twining , Vladimir S. Petrović , Timothy F. Cootes , Roy S. Schestowitz , William R. Crum , Christopher J. Taylor

A central obstacle in the objective assessment of treatment effect (TE) estimators in randomized control trials (RCTs) is the lack of ground truth (or validation set) to test their performance. In this paper, we propose a novel…

Despite the increasing demand for safer machine learning practices, the use of Uncertainty Quantification (UQ) methods in production remains limited. This limitation is exacerbated by the challenge of validating UQ methods in absence of UQ…

Machine Learning · Computer Science 2025-03-03 Arthur Pignet , Chiara Regniez , John Klein

With the increasing availability of datasets, developing data fusion methods to leverage the strengths of different datasets to draw causal effects is of great practical importance to many scientific fields. In this paper, we consider…

Methodology · Statistics 2023-07-18 Yijiao Zhang , Zhongyi Zhu

Objective:To develop a no-reference image quality assessment method using automated distortion recognition to boost MRI-guided radiotherapy precision.Methods:We analyzed 106,000 MR images from 10 patients with liver metastasis,captured with…

Image and Video Processing · Electrical Eng. & Systems 2024-12-11 Zilin Wang , Shengqi Chen , Jianrong Dai , Shirui Qin , Ying Cao , Ruiao Zhao , Guohua Wu , Yuan Tang , Jiayun Chen

Real-World Data (RWD), with its large sample sizes and rich clinical detail, offers a compelling alternative to randomized controlled trials (RCTs) for studying treatment effects in diverse and complex patient populations. However, its…

Applications · Statistics 2026-05-26 Yifei Xu , Hwiyoung Lee , Zhenyao Ye , Yezhi Pan , Jingsong Zhou , Yun Yang , Chixiang Chen , Shuo Chen

In the field of quantitative imaging, the image information at a pixel or voxel in an underlying domain entails crucial information about the imaged matter. This is particularly important in medical imaging applications, such as…

Optimization and Control · Mathematics 2024-04-12 Guozhi Dong , Moritz Flaschel , Michael Hintermüller , Kostas Papafitsoros , Clemens Sirotenko , Karsten Tabelow

Over the last few years, debiased estimators have been proposed in order to establish rigorous confidence intervals for high-dimensional problems in machine learning and data science. The core argument is that the error of these estimators…

Signal Processing · Electrical Eng. & Systems 2024-07-19 Frederik Hoppe , Claudio Mayrink Verdun , Felix Krahmer , Marion I. Menzel , Holger Rauhut

AI models are often evaluated based on their ability to predict the outcome of interest. However, in many AI for social impact applications, the presence of an intervention that affects the outcome can bias the evaluation. Randomized…

Machine Learning · Computer Science 2025-11-18 Winston Chen , Michael W. Sjoding , Jenna Wiens

Confounding is a significant obstacle to unbiased estimation of causal effects from observational data. For settings with high-dimensional covariates -- such as text data, genomics, or the behavioral social sciences -- researchers have…

Artificial Intelligence · Computer Science 2024-02-01 Katherine A. Keith , Sergey Feldman , David Jurgens , Jonathan Bragg , Rohit Bhattacharya

Constructing valid prediction intervals rather than point estimates is a well-established approach for uncertainty quantification in the regression setting. Models equipped with this capacity output an interval of values in which the ground…

Machine Learning · Statistics 2025-02-07 Thomas Pouplin , Alan Jeffares , Nabeel Seedat , Mihaela van der Schaar

Causal weighted quantile treatment effects (WQTE) are a useful complement to standard causal contrasts that focus on the mean when interest lies at the tails of the counterfactual distribution. To-date, however, methods for estimation and…

Evaluating generative models for synthetic medical imaging is crucial yet challenging, especially given the high standards of fidelity, anatomical accuracy, and safety required for clinical applications. Standard evaluation of generated…

Image and Video Processing · Electrical Eng. & Systems 2025-05-13 Yash Deo , Yan Jia , Toni Lassila , William A. P. Smith , Tom Lawton , Siyuan Kang , Alejandro F. Frangi , Ibrahim Habli

Deep neural networks, while achieving remarkable success across diverse tasks, demand significant resources, including computation, GPU memory, bandwidth, storage, and energy. Network quantization, as a standard compression and acceleration…

Computer Vision and Pattern Recognition · Computer Science 2025-07-09 Minghao Fu , Hao Yu , Jie Shao , Junjie Zhou , Ke Zhu , Jianxin Wu

The development of large-scale platforms for quantum information requires new methods for verification and validation of quantum behavior. Quantum tomography (QT) is the standard tool for diagnosing quantum states, process, and readout…

Quantum Physics · Physics 2017-01-10 Charles H. Baldwin
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