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Convolutional neural networks (CNNs) have achieved remarkable performance in hyperspectral image (HSI) classification over the last few years. Despite the progress that has been made, rich and informative spectral information of HSI has…

Computer Vision and Pattern Recognition · Computer Science 2024-07-09 Huiling Wang

We propose a novel efficient architecture for learning long-term evolution in complex multi-scale physical systems which is based on the idea of separation of scales. Structures of various scales that dynamically emerge in the system…

Artificial Intelligence · Computer Science 2025-05-27 Alexander Khrabry , Edward Startsev , Andrew Powis , Igor Kaganovich

Analysis of single-cell transcriptomics often relies on clustering cells and then performing differential gene expression (DGE) to identify genes that vary between these clusters. These discrete analyses successfully determine cell types…

Quantitative Methods · Quantitative Biology 2022-10-07 Renee S. Hoekzema , Lewis Marsh , Otto Sumray , Thomas M. Carroll , Xin Lu , Helen M. Byrne , Heather A. Harrington

With ongoing developments and innovations in single-cell RNA sequencing methods, advancements in sequencing performance could empower significant discoveries as well as new emerging possibilities to address biological and medical…

Applications · Statistics 2019-12-19 Jiawei Long , Yu Xia

Long non-coding RNA, microRNA, and messenger RNA enable key regulations of various biological processes through a variety of diverse interaction mechanisms. Identifying the interactions and cross-talk between these heterogeneous RNA classes…

Molecular Networks · Quantitative Biology 2020-12-10 Nhat Tran , Jean Gao

Single-cell RNA sequencing (scRNA-seq) data exhibit strong and reproducible statistical structure. This has motivated the development of large-scale foundation models, such as TranscriptFormer, that use transformer-based architectures to…

Genomics · Quantitative Biology 2026-02-19 Huan Souza , Pankaj Mehta

Improving the scalability of GNNs is critical for large graphs. Existing methods leverage three sampling paradigms including node-wise, layer-wise and subgraph sampling, then design unbiased estimator for scalability. However, the high…

Machine Learning · Computer Science 2022-11-21 Yang Li , Bingbing Xu , Qi Cao , Yige Yuan , Huawei Shen

Hyperspectral satellite imagery offers sub-30 m views of Earth in hundreds of contiguous spectral bands, enabling fine-grained mapping of soils, crops, and land cover. While self-supervised Masked Autoencoders excel on RGB and low-band…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Tanjim Bin Faruk , Abdul Matin , Shrideep Pallickara , Sangmi Lee Pallickara

Sparse autoencoders (SAEs) have lately been used to uncover interpretable latent features in large language models. By projecting dense embeddings into a much higher-dimensional and sparse space, learned features become disentangled and…

Machine Learning · Computer Science 2025-07-30 Viktoria Schuster

We propose a probabilistic model for interpreting gene expression levels that are observed through single-cell RNA sequencing. In the model, each cell has a low-dimensional latent representation. Additional latent variables account for…

Machine Learning · Computer Science 2017-10-18 Romain Lopez , Jeffrey Regier , Michael Cole , Michael Jordan , Nir Yosef

Identifying meaningful structure across multiple scales remains a central challenge in network science. We introduce Hierarchical Clustering Entropy (HCE), a general and model-agnostic framework for detecting informative levels in…

Social and Information Networks · Computer Science 2025-08-07 Jorge Martinez Armas

A Sheaf Neural Network (SNN) is a type of Graph Neural Network (GNN) that operates on a sheaf, an object that equips a graph with vector spaces over its nodes and edges and linear maps between these spaces. SNNs have been shown to have…

Nonlinear data visualization using t-distributed stochastic neighbor embedding (t-SNE) enables the representation of complex single-cell transcriptomic landscapes in two or three dimensions to depict biological populations accurately.…

Genomics · Quantitative Biology 2024-10-02 Hui Ma , Kai Chen

Deep neural networks have exhibited promising performance in image super-resolution (SR). Most SR models follow a hierarchical architecture that contains both the cell-level design of computational blocks and the network-level design of the…

Computer Vision and Pattern Recognition · Computer Science 2020-08-26 Yong Guo , Yongsheng Luo , Zhenhao He , Jin Huang , Jian Chen

We introduce Locally Linear Embedding (LLE) to the astronomical community as a new classification technique, using SDSS spectra as an example data set. LLE is a nonlinear dimensionality reduction technique which has been studied in the…

Instrumentation and Methods for Astrophysics · Physics 2015-05-13 J. T. VanderPlas , A. J. Connolly

Single-cell RNA-sequencing technologies may provide valuable insights to the understanding of the composition of different cell types and their functions within a tissue. Recent technologies such as spatial transcriptomics, enable the…

Applications · Statistics 2023-05-16 Arhit Chakrabarti , Yang Ni , Bani K. Mallick

Single-cell RNA sequencing (scRNA-seq) enables dissecting cellular heterogeneity in tissues, resulting in numerous biological discoveries. Various computational methods have been devised to delineate cell types by clustering scRNA-seq data…

Quantitative Methods · Quantitative Biology 2023-09-18 Tram Huynh , Zixuan Cang

Node representations, or embeddings, are low-dimensional vectors that capture node properties, typically learned through unsupervised structural similarity objectives or supervised tasks. While recent efforts have focused on explaining…

Machine Learning · Computer Science 2025-10-17 Simone Piaggesi , André Panisson , Megha Khosla

Recent work has developed Bayesian methods for the automatic statistical analysis and description of single time series as well as of homogeneous sets of time series data. We extend prior work to create an interpretable kernel embedding for…

Machine Learning · Computer Science 2019-08-27 Andre T. Nguyen , Edward Raff

Single-cell RNA sequencing (scRNA-seq) has revolutionized our ability to analyze gene expression at the resolution of individual cells, providing unprecedented insights into cellular heterogeneity and complex biological systems. This paper…

Other Quantitative Biology · Quantitative Biology 2024-06-11 Megha Patel , Nimish Magre , Himanshi Motwani , Nik Bear Brown
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