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Multi-modal foundation models are typically trained on millions of pairs of natural images and text captions, frequently obtained through web-crawling approaches. Although such models depict excellent generative capabilities, they do not…

Computer Vision and Pattern Recognition · Computer Science 2023-01-03 Pierre Chambon , Christian Bluethgen , Curtis P. Langlotz , Akshay Chaudhari

Spatial Transcriptomics (ST) technologies provide biologists with rich insights into single-cell biology by preserving spatial context of cells. Building foundational models for ST can significantly enhance the analysis of vast and complex…

Genomics · Quantitative Biology 2025-07-24 Suyuan Zhao , Yizhen Luo , Ganbo Yang , Yan Zhong , Hao Zhou , Zaiqing Nie

While learned image compression (LIC) focuses on efficient data transmission, generative image compression (GIC) extends this framework by integrating generative modeling to produce photo-realistic reconstructed images. In this paper, we…

Image and Video Processing · Electrical Eng. & Systems 2025-05-28 Minghao Han , Weiyi You , Jinhua Zhang , Leheng Zhang , Ce Zhu , Shuhang Gu

The rapid growth of digital pathology and advances in self-supervised deep learning have enabled the development of foundational models for various pathology tasks across diverse diseases. While multimodal approaches integrating diverse…

Computer Vision and Pattern Recognition · Computer Science 2025-10-15 Ekaterina Redekop , Mara Pleasure , Zichen Wang , Kimberly Flores , Anthony Sisk , William Speier , Corey W. Arnold

Stable Diffusion (SD) has gained a lot of attention in recent years in the field of Generative AI thus helping in synthesizing medical imaging data with distinct features. The aim is to contribute to the ongoing effort focused on overcoming…

Computer Vision and Pattern Recognition · Computer Science 2024-02-13 Ayman Abaid , Muhammad Ali Farooq , Niamh Hynes , Peter Corcoran , Ihsan Ullah

Pathology image are essential for accurately interpreting lesion cells in cytopathology screening, but acquiring high-resolution digital slides requires specialized equipment and long scanning times. Though super-resolution (SR) techniques…

Computer Vision and Pattern Recognition · Computer Science 2024-06-27 Wenting Chen , Jie Liu , Tommy W. S. Chow , Yixuan Yuan

A generative modeling framework is proposed that combines diffusion models and manifold learning to efficiently sample data densities on manifolds. The approach utilizes Diffusion Maps to uncover possible low-dimensional underlying (latent)…

Machine Learning · Computer Science 2025-04-22 Dimitris G. Giovanis , Ellis Crabtree , Roger G. Ghanem , Ioannis G. Kevrekidis

Predicting spatial gene expression from routine H\&E enables large-scale molecular profiling, yet current models treat this as isolated pointwise tasks, thereby overlooking essential biological structures like gene coordination and spatial…

Machine Learning · Computer Science 2026-05-19 Qi Si , Penglei Wang , Yushuai Wu , Yifeng Jiao , Xuyang Liu , Xin Guo , Yuan Qi , Yuan Cheng

Spatially resolved transcriptomics represents a significant advancement in single-cell analysis by offering both gene expression data and their corresponding physical locations. However, this high degree of spatial resolution entails a…

Genomics · Quantitative Biology 2024-03-19 Xiaoyu Li , Wenwen Min , Shunfang Wang , Changmiao Wang , Taosheng Xu

Spatial-temporal graph learning has emerged as a promising solution for modeling structured spatial-temporal data and learning region representations for various urban sensing tasks such as crime forecasting and traffic flow prediction.…

Machine Learning · Computer Science 2023-06-21 Qianru Zhang , Chao Huang , Lianghao Xia , Zheng Wang , Siuming Yiu , Ruihua Han

Spatial transcriptomics enables interrogating the molecular composition of tissue with ever-increasing resolution and sensitivity. However, costs, rapidly evolving technology, and lack of standards have constrained computational methods in…

Text-to-Image Diffusion Models such as Stable-Diffusion and Imagen have achieved unprecedented quality of photorealism with state-of-the-art FID scores on MS-COCO and other generation benchmarks. Given a caption, image generation requires…

Computer Vision and Pattern Recognition · Computer Science 2023-10-24 Samyadeep Basu , Nanxuan Zhao , Vlad Morariu , Soheil Feizi , Varun Manjunatha

Recent advances in generative artificial intelligence have enabled the creation of high-quality synthetic data that closely mimics real-world data. This paper explores the adaptation of the Stable Diffusion 2.0 model for generating…

Machine Learning · Computer Science 2024-05-07 Eugenio Lomurno , Matteo D'Oria , Matteo Matteucci

With the rapid advancement of diffusion-based generative models, Stable Diffusion (SD) has emerged as a state-of-the-art framework for high-fidelity im-age synthesis. However, existing SD models suffer from suboptimal feature aggregation,…

Graphics · Computer Science 2025-07-21 Zhen-Qi Chen , Yuan-Fu Yang

Hyperspectral Image (HSI) classification is an important issue in remote sensing field with extensive applications in earth science. In recent years, a large number of deep learning-based HSI classification methods have been proposed.…

Computer Vision and Pattern Recognition · Computer Science 2023-09-04 Ning Chen , Jun Yue , Leyuan Fang , Shaobo Xia

Inferring spatially resolved gene expression from histology images offers a cost-effective complement to spatial transcriptomics (ST). However, existing methods reduce this task to a simple morphology-to-expression mapping, where visual…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Junchao Zhu , Ruining Deng , Junlin Guo , Tianyuan Yao , Chongyu Qu , Juming Xiong , Zhengyi Lu , Yanfan Zhu , Marilyn Lionts , Yuechen Yang , Yu Wang , Shilin Zhao , Haichun Yang , Yuankai Huo

Diffusion models dominate image editing, yet their global denoising mechanism entangles edited regions with surrounding context, causing modifications to propagate into areas that should remain intact. We propose a fundamentally different…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Wei Chow , Linfeng Li , Xian Sun , Lingdong Kong , Zefeng Li , Qi Xu , Hang Song , Tian Ye , Xian Wang , Jinbin Bai , Shilin Xu , Xiangtai Li , Junting Pan , Shaoteng Liu , Ran Zhou , Tianshu Yang , Songhua Liu

The rapid advancement of generative models, such as Stable Diffusion, raises a key question: how can synthetic data from these models enhance predictive modeling? While they can generate vast amounts of datasets, only a subset meaningfully…

Machine Learning · Statistics 2025-05-09 Jialong Jiang , Wenkang Hu , Jian Huang , Yuling Jiao , Xu Liu

The tremendous progress in neural image generation, coupled with the emergence of seemingly omnipotent vision-language models has finally enabled text-based interfaces for creating and editing images. Handling generic images requires a…

Computer Vision and Pattern Recognition · Computer Science 2023-07-27 Omri Avrahami , Ohad Fried , Dani Lischinski

Self-supervised learning has demonstrated considerable potential in hyperspectral representation, yet its application in cross-domain transfer scenarios remains under-explored. Existing methods, however, still rely on source domain…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Jianshu Chao , Tianhua Lv , Qiqiong Ma , Yunfei Qiu , Li Fang , Huifang Shen , Wei Yao