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Large Language Models (LLMs) like LLaMA, Mistral, and Gemma are increasingly used in decision-critical domains such as healthcare, law, and finance, yet their reliability remains uncertain. They often make overconfident errors, degrade…

Computation and Language · Computer Science 2026-01-01 Rohit Kumar Salla , Manoj Saravanan , Shrikar Reddy Kota

Computational pathology demands both visual pattern recognition and dynamic integration of structured domain knowledge, including taxonomy, grading criteria, and clinical evidence. In practice, diagnostic reasoning requires linking…

Artificial Intelligence · Computer Science 2026-05-26 Jinyue Li , Yuci Liang , Qiankun Li , Xinheng Lyu , Jiayu Qian , Huabao Chen , Kun Wang , Zhigang Zeng , Anil Anthony Bharath , Yang Liu

Large language model (LLM) systems are increasingly used to support high-stakes decision-making, but they typically perform worse when the available evidence is internally inconsistent. Such a scenario exists in real-world healthcare…

Computation and Language · Computer Science 2026-04-02 Haochen Liu , Weien Li , Rui Song , Zeyu Li , Chun Jason Xue , Xiao-Yang Liu , Sam Nallaperuma , Xue Liu , Ye Yuan

Robust tooling and publicly available pre-trained models have helped drive recent advances in mechanistic interpretability for language models. However, similar progress in vision mechanistic interpretability has been hindered by the lack…

Computer Vision and Pattern Recognition · Computer Science 2025-06-04 Sonia Joseph , Praneet Suresh , Lorenz Hufe , Edward Stevinson , Robert Graham , Yash Vadi , Danilo Bzdok , Sebastian Lapuschkin , Lee Sharkey , Blake Aaron Richards

Personalized alignment is crucial for enabling Large Language Models (LLMs) to engage effectively in user-centric interactions. However, current methods face a dual challenge: they fail to infer users' deep implicit preferences (including…

Artificial Intelligence · Computer Science 2026-04-29 Peiming Li , Zhiyuan Hu , Yang Tang , Shiyu Li , Xi Chen

Language agents powered by large language models (LLMs) have demonstrated remarkable capabilities in understanding, reasoning, and executing complex tasks. However, developing robust agents presents significant challenges: substantial…

Computation and Language · Computer Science 2025-06-02 Qianqian Zhang , Jiajia Liao , Heting Ying , Yibo Ma , Haozhan Shen , Jingcheng Li , Peng Liu , Lu Zhang , Chunxin Fang , Kyusong Lee , Ruochen Xu , Tiancheng Zhao

Harmonizing medication data across Electronic Health Record (EHR) systems is a persistent barrier to monitoring medications for opioid use disorder (MOUD). In heterogeneous EHR systems, key prescription attributes are scattered across…

Artificial Intelligence · Computer Science 2025-10-27 Zhe Fei , Mehmet Yigit Turali , Shreyas Rajesh , Xinyang Dai , Huyen Pham , Pavan Holur , Yuhui Zhu , Larissa Mooney , Yih-Ing Hser , Vwani Roychowdhury

The extraction of pharmacological knowledge from regulatory documents has become a key focus in biomedical natural language processing, with applications ranging from adverse event monitoring to AI-assisted clinical decision support.…

Computation and Language · Computer Science 2025-10-22 Mariano Barone , Antonio Laudante , Giuseppe Riccio , Antonio Romano , Marco Postiglione , Vincenzo Moscato

Background: Medication review is a structured interview of the patient, performed by the pharmacist and aimed at optimizing drug treatments. In practice, medication review is a long and cognitively-demanding task that requires specific…

Industrial processes must be robust and adaptable, as environments and tasks are often unpredictable, while operational errors remain costly and difficult to detect. AI-based control systems offer a path forward, yet typically depend on…

Artificial Intelligence · Computer Science 2025-06-11 Christos Margadji , Sebastian W. Pattinson

Software supply chain attacks have revealed blind spots in existing SCA tools, which are often limited to a single ecosystem and assess either software artifacts or community activity in isolation. This fragmentation across tools and…

Software Engineering · Computer Science 2025-12-02 Ziheng Liu , Runzhi He , Minghui Zhou

Efficiently updating Large Language Models (LLMs) with new or evolving factual knowledge remains a central challenge, as even parameter-efficient adaptation can erode previously acquired reasoning abilities. This tension reflects a…

Artificial Intelligence · Computer Science 2026-05-26 Mustafa Hayri Bilgin , Mariam Barry , Albert Bifet , Azzedine Idir Ait Said , Soumya Banerjee

Automated interpretability research aims to identify concepts encoded in neural network features to enhance human understanding of model behavior. Within the context of large language models (LLMs) for natural language processing (NLP),…

Machine Learning · Computer Science 2025-11-13 Laura Kopf , Nils Feldhus , Kirill Bykov , Philine Lou Bommer , Anna Hedström , Marina M. -C. Höhne , Oliver Eberle

The deployment of Large Language Models (LLMs) for structuring clinical data is critically hindered by their tendency to hallucinate facts and their inability to follow domain-specific rules. To address this, we introduce MedPAO, a novel…

Current Large Language Models (LLMs) exhibit significant limitations, notably in structured, interpretable, and verifiable medical reasoning, alongside practical deployment challenges related to computational resources and data privacy.…

Computation and Language · Computer Science 2025-06-06 Boqin Zhuang , Chenxiao Song , Huitong Lu , Jiacheng Qiao , Mingqian Liu , Mingxing Yu , Ping Hong , Rui Li , Xiaoxia Song , Xiangjun Xu , Xu Chen , Yaoyao Ma , Yujie Gao

Annotation pipelines in Natural Language Processing (NLP) commonly assume a single latent ground truth per instance and resolve disagreement through label aggregation. Perspectivist approaches challenge this view by treating disagreement as…

Computation and Language · Computer Science 2026-04-23 Olga Kellert , Sriya Kondury , Candice Koo , Nemika Tyagi , Steffen Eikenberry

The exponential increase in scientific literature and online information necessitates efficient methods for extracting knowledge from textual data. Natural language processing (NLP) plays a crucial role in addressing this challenge,…

Computation and Language · Computer Science 2025-10-22 Zhyar Rzgar K. Rostam , Gábor Kertész

Drug recommendation requires a deep understanding of individual patient context, especially for complex conditions like Parkinson's disease. While LLMs possess broad medical knowledge, they fail to capture the subtle nuances of actual…

Computation and Language · Computer Science 2026-03-19 Chaeyoung Huh , Hyunmin Hwang , Jung Hwan Shin , Jinse Park , Jong Chul Ye

We present Athena-PRM, a multimodal process reward model (PRM) designed to evaluate the reward score for each step in solving complex reasoning problems. Developing high-performance PRMs typically demands significant time and financial…

Machine Learning · Computer Science 2026-05-27 Shuai Wang , Zhenhua Liu , Jiaheng Wei , Xuanwu Yin , Dong Li , Emad Barsoum

When automated decision systems fail, organizations frequently discover that formally compliant governance infrastructure cannot reconstruct what happened or why. This paper synthesizes an operational governance evidence framework --…

Computers and Society · Computer Science 2026-04-27 Oleg Solozobov