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Large language models (LLMs) solve complex problems by generating multi-step reasoning traces. Yet these traces are typically analyzed from only one of two perspectives: the sequence of tokens across different reasoning steps in the…

Computation and Language · Computer Science 2026-03-25 Ruidi Chang , Jiawei Zhou , Hanjie Chen

This paper presents a tri-agent cross-validation framework for analyzing stability and explainability in multi-model large language systems. The architecture integrates three heterogeneous LLMs-used for semantic generation, analytical…

Computation and Language · Computer Science 2026-01-15 Toshiyuki Shigemura

Large language models are increasingly integrated into decision-making in areas such as healthcare, law, finance, engineering, and government. Yet they share a critical limitation: they produce fluent outputs even when their internal…

Artificial Intelligence · Computer Science 2026-04-17 Rikard Rosenbacke , Carl Rosenbacke , Victor Rosenbacke , Martin McKee

Proteins are essential biological macromolecules that execute life functions. Local structural motifs, such as active sites, are the most critical components for linking structure to function and are key to understanding protein evolution…

Quantitative Methods · Quantitative Biology 2026-04-10 Zhiyu Wang , Bingxin Zhou , Jing Wang , Yang Tan , Weishu Zhao , Pietro Liò , Liang Hong

Laboratory workflows in pharmaceutical and biomedical research encode substantial tacit knowledge -- expert judgment about failure conditions, decision branching logic, and contextual dependencies -- that remains inaccessible to protocol…

Learning medical visual representations from image-report pairs through joint learning has garnered increasing research attention due to its potential to alleviate the data scarcity problem in the medical domain. The primary challenges stem…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Jun Wang , Lixing Zhu , Xiaohan Yu , Abhir Bhalerao , Yulan He

Medical document analysis plays a crucial role in extracting essential clinical insights from unstructured healthcare records, supporting critical tasks such as differential diagnosis. Determining the most probable condition among…

Artificial Intelligence · Computer Science 2025-06-25 Lei Kang , Xuanshuo Fu , Oriol Ramos Terrades , Javier Vazquez-Corral , Ernest Valveny , Dimosthenis Karatzas

Linear relaxation based perturbation analysis (LiRPA) for neural networks, which computes provable linear bounds of output neurons given a certain amount of input perturbation, has become a core component in robustness verification and…

Machine Learning · Computer Science 2020-10-27 Kaidi Xu , Zhouxing Shi , Huan Zhang , Yihan Wang , Kai-Wei Chang , Minlie Huang , Bhavya Kailkhura , Xue Lin , Cho-Jui Hsieh

Since 2022, AI-powered coding assistants have produced contradictory evidence: controlled studies report 20-56% productivity gains on well-scoped tasks, while the most rigorous RCT documents a 19% slowdown for experienced developers, and…

Software Engineering · Computer Science 2026-05-05 Sabry E. Farrag

Large Language Models (LLMs) have exhibited remarkable capabilities in understanding and interacting with natural language across various sectors. However, their effectiveness is limited in specialized areas requiring high accuracy, such as…

Computation and Language · Computer Science 2024-01-04 Xianjun Yang , Junfeng Gao , Wenxin Xue , Erik Alexandersson

Clinical Decision Support Systems (CDSSs) provide reasoning and inquiry guidance for physicians, yet they face notable challenges, including high maintenance costs and low generalization capability. Recently, Large Language Models (LLMs)…

Computation and Language · Computer Science 2026-04-24 Yue Guo , Fanfu Wang , Jianwei Lv , Xincheng Shi , Yuchen Li , Youya Wang , Yunsheng Zeng , Yujing Liu , Yunhao Qiao , Gen Li , Junfeng Wang , Bo Yuan

Justifying the correct implementation of the non-functional requirements (e.g., safety, security) of mission-critical systems is crucial to prevent system failure. The later could have severe consequences such as the death of people and…

Software Engineering · Computer Science 2024-07-09 Oluwafemi Odu , Alvine Boaye Belle , Song Wang , Kimya Khakzad Shahandashti

Importance: We introduce a novel Retrieval Augmented Generation (RAG)-Large Language Model (LLM) framework as a Clinical Decision Support Systems (CDSS) to support safe medication prescription. Objective: To evaluate the efficacy of…

Medical diagnosis requires the effective synthesis of visual manifestations and clinical metadata. However, existing methods often treat metadata as isolated tags, failing to exploit the rich semantic knowledge embedded in clinical…

Computer Vision and Pattern Recognition · Computer Science 2026-02-27 Yiqing Wang , Chunming He , Ming-Chen Lu , Mercy Pawar , Leslie Niziol , Maria Woodward , Sina Farsiu

Large language models (LLMs) show promise for healthcare question answering, but clinical use is limited by weak verification, insufficient evidence grounding, and unreliable confidence signalling. We propose a multi-agent medical QA…

Computation and Language · Computer Science 2026-02-17 Naeimeh Nourmohammadi , Md Meem Hossain , The Anh Han , Safina Showkat Ara , Zia Ush Shamszaman

We present a novel framework that bridges the gap between the interpretability of decision trees and the advanced reasoning capabilities of large language models (LLMs) to predict startup success. Our approach leverages chain-of-thought…

Artificial Intelligence · Computer Science 2025-04-17 Jack Preuveneers , Joseph Ternasky , Fuat Alican , Yigit Ihlamur

Large visual language models (VLMs) have shown strong multi-modal medical reasoning ability, but most operate as end-to-end black boxes, diverging from clinicians' evidence-based, staged workflows and hindering clinical accountability.…

Artificial Intelligence · Computer Science 2026-03-12 Yuexi Du , Jinglu Wang , Shujie Liu , Nicha C. Dvornek , Yan Lu

The automation of the medical evidence acquisition and diagnosis process has recently attracted increasing attention in order to reduce the workload of doctors and democratize access to medical care. However, most works proposed in the…

Computation and Language · Computer Science 2022-10-14 Arsene Fansi Tchango , Rishab Goel , Julien Martel , Zhi Wen , Gaetan Marceau Caron , Joumana Ghosn

The rapid growth in submissions to machine learning venues has strained the scientific peer-review system and intensified interest in LLM-based automated peer reviewers. However, how good these systems are actually, especially compared to…

Answering complex medical questions requires not only domain expertise and patient-specific information, but also structured and multi-perspective reasoning. Existing multi-agent approaches often rely on fixed roles or shallow interaction…

Artificial Intelligence · Computer Science 2026-03-04 Siqi Ma , Jiajie Huang , Fan Zhang , Yue Shen , Jinlin Wu , Guohui Fan , Zhu Zhang , Zelin Zang
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