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Multimodal deep learning has shown strong potential in medical applications by integrating heterogeneous data sources such as medical images and structured clinical variables. However, most existing approaches implicitly assume complete…

Machine Learning · Computer Science 2026-05-13 Camillo Maria Caruso , Valerio Guarrasi , Paolo Soda

Multimodal pathology-genomic analysis has become increasingly prominent in cancer survival prediction. However, existing studies mainly utilize multi-instance learning to aggregate patch-level features, neglecting the information loss of…

Computer Vision and Pattern Recognition · Computer Science 2025-05-21 Mingcheng Qu , Guang Yang , Donglin Di , Tonghua Su , Yue Gao , Yang Song , Lei Fan

Predicting survival outcomes for non-small cell lung cancer (NSCLC) patients is challenging due to the different individual prognostic features. This task can benefit from the integration of whole-slide images, bulk transcriptomics, and DNA…

Accurate brain tumor segmentation is essential for preoperative evaluation and personalized treatment. Multi-modal MRI is widely used due to its ability to capture complementary tumor features across different sequences. However, in…

Computer Vision and Pattern Recognition · Computer Science 2025-09-19 Shenghao Zhu , Yifei Chen , Weihong Chen , Shuo Jiang , Guanyu Zhou , Yuanhan Wang , Feiwei Qin , Changmiao Wang , Qiyuan Tian

In clinical practice, full imaging is not always feasible, often due to complex acquisition protocols, stringent privacy regulations, or specific clinical needs. However, missing MR modalities pose significant challenges for tasks like…

Computer Vision and Pattern Recognition · Computer Science 2025-01-23 Aghiles Kebaili , Jérôme Lapuyade-Lahorgue , Pierre Vera , Su Ruan

Multimodal MRI provides critical complementary information for accurate brain tumor segmentation. However, conventional methods struggle when certain modalities are missing due to issues such as image quality, protocol inconsistencies,…

Computer Vision and Pattern Recognition · Computer Science 2025-07-03 Runze Cheng , Xihang Qiu , Ming Li , Ye Zhang , Chun Li , Fei Yu

Cancer prognosis and survival outcome predictions are crucial for therapeutic response estimation and for stratifying patients into various treatment groups. Medical domains concerned with cancer prognosis are abundant with multiple…

Image and Video Processing · Electrical Eng. & Systems 2024-02-29 Ruining Deng , Nazim Shaikh , Gareth Shannon , Yao Nie

Multimodal data collected from the real world are often imperfect due to missing modalities. Therefore multimodal models that are robust against modal-incomplete data are highly preferred. Recently, Transformer models have shown great…

Computer Vision and Pattern Recognition · Computer Science 2022-04-13 Mengmeng Ma , Jian Ren , Long Zhao , Davide Testuggine , Xi Peng

While multimodal data integrating diverse imaging and clinical tabular records is crucial for accurate medical diagnosis, the arbitrary absence of specific modalities is prevalent in clinical practice, severely degrading the performance of…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Tianling Liu , Lequan Yu , Tong Han , Liang Wan

Multimodal learning has demonstrated incredible successes by integrating diverse data sources, yet it often relies on the availability of all modalities - an assumption that rarely holds in real-world applications. Pretrained multimodal…

Machine Learning · Computer Science 2025-04-21 Duy A. Nguyen , Quan Huu Do , Khoa D. Doan , Minh N. Do

Learning multimodal representations from medical images and other data sources can provide richer information for decision-making. While various multimodal models have been developed for this, they overlook learning features that are both…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Boyu Chen , Weiye Bao , Junjie Liu , Michael Shen , Bo Peng , Paul Taylor , Zhu Li , Mengyue Yang

Histo-genomic multimodal survival prediction has garnered growing attention for its remarkable model performance and potential contributions to precision medicine. However, a significant challenge in clinical practice arises when only…

Machine Learning · Computer Science 2025-03-17 Fengchun Liu , Linghan Cai , Zhikang Wang , Zhiyuan Fan , Jin-gang Yu , Hao Chen , Yongbing Zhang

Histopathology and transcriptomics are fundamental modalities in oncology, encapsulating the morphological and molecular aspects of the disease. Multi-modal self-supervised learning has demonstrated remarkable potential in learning…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Tianyi Wang , Jianan Fan , Dingxin Zhang , Dongnan Liu , Yong Xia , Heng Huang , Weidong Cai

Brain tumor segmentation is often based on multiple magnetic resonance imaging (MRI). However, in clinical practice, certain modalities of MRI may be missing, which presents an even more difficult scenario. To cope with this challenge,…

Image and Video Processing · Electrical Eng. & Systems 2025-01-16 Tianyi Liu , Zhaorui Tan , Haochuan Jiang , Xi Yang , Kaizhu Huang

In multi-modal learning, some modalities are more influential than others, and their absence can have a significant impact on classification/segmentation accuracy. Addressing this challenge, we propose a novel approach called Meta-learned…

Computer Vision and Pattern Recognition · Computer Science 2025-08-27 Hu Wang , Salma Hassan , Yuyuan Liu , Congbo Ma , Yuanhong Chen , Qing Li , Jiahui Geng , Bingjie Wang , Yu Tian , Yutong Xie , Jodie Avery , Louise Hull , Ian Reid , Mohammad Yaqub , Gustavo Carneiro

Aggregating multi-modality data to obtain reliable data representation attracts more and more attention. Recent studies demonstrate that Transformer models usually work well for multi-modality tasks. Existing Transformers generally either…

Computer Vision and Pattern Recognition · Computer Science 2023-03-17 Xixi Wang , Xiao Wang , Bo Jiang , Jin Tang , Bin Luo

Cancer subtype classification is crucial for personalized treatment and prognostic assessment. However, effectively integrating multi-omic data remains challenging due to the heterogeneous nature of genomic, epigenomic, and transcriptomic…

Machine Learning · Computer Science 2025-06-10 Sajib Acharjee Dip , Uddip Acharjee Shuvo , Dipanwita Mallick , Abrar Rahman Abir , Liqing Zhang

Continual learning is essential for adapting models to new tasks while retaining previously acquired knowledge. While existing approaches predominantly focus on uni-modal data, multi-modal learning offers substantial benefits by utilizing…

Machine Learning · Computer Science 2025-11-11 Evelyn Chee , Wynne Hsu , Mong Li Lee

Brain tumor segmentation based on multi-modal magnetic resonance imaging (MRI) plays a pivotal role in assisting brain cancer diagnosis, treatment, and postoperative evaluations. Despite the achieved inspiring performance by existing…

Image and Video Processing · Electrical Eng. & Systems 2022-11-16 Haoran Li , Cheng Li , Weijian Huang , Xiawu Zheng , Yan Xi , Shanshan Wang

With the growing success of multi-modal learning, research on the robustness of multi-modal models, especially when facing situations with missing modalities, is receiving increased attention. Nevertheless, previous studies in this domain…

Artificial Intelligence · Computer Science 2023-10-11 Siting Li , Chenzhuang Du , Yue Zhao , Yu Huang , Hang Zhao