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The limited data availability due to strict privacy regulations and significant resource demands severely constrains biomedical time-series AI development, which creates a critical gap between data requirements and accessibility. Synthetic…

Machine Learning · Computer Science 2025-11-25 Youngjoon Lee , Seongmin Cho , Yehhyun Jo , Jinu Gong , Hyunjoo Jenny Lee , Joonhyuk Kang

Large language models (LLMs) hold potential for innovative HCI research, including the creation of synthetic personae. However, their black-box nature and propensity for hallucinations pose challenges. To address these limitations, this…

Artificial Intelligence · Computer Science 2024-04-18 Rafael Arias Gonzalez , Steve DiPaola

Large language models (LLMs), including zero-shot and few-shot paradigms, have shown promising capabilities in clinical text generation. However, real-world applications face two key challenges: (1) patient data is highly unstructured,…

Computation and Language · Computer Science 2025-07-10 Garapati Keerthana , Manik Gupta

Synthetic tabular data is essential for machine learning workflows, especially for expanding small or imbalanced datasets and enabling privacy-preserving data sharing. However, state-of-the-art generative models (GANs, VAEs, diffusion…

Machine Learning · Computer Science 2025-07-24 Jessup Byun , Xiaofeng Lin , Joshua Ward , Guang Cheng

The generation of synthetic medical records using Generative Adversarial Networks (GANs) is becoming crucial for addressing privacy concerns and facilitating data sharing in the medical domain. In this paper, we introduce a novel method to…

Image and Video Processing · Electrical Eng. & Systems 2023-09-20 Tomohiro Kikuchi , Shouhei Hanaoka , Takahiro Nakao , Tomomi Takenaga , Yukihiro Nomura , Harushi Mori , Takeharu Yoshikawa

Swarm learning (SL) is an emerging promising decentralized machine learning paradigm and has achieved high performance in clinical applications. SL solves the problem of a central structure in federated learning by combining edge computing…

Machine Learning · Computer Science 2022-12-05 Zirui Wang , Shaoming Duan , Chengyue Wu , Wenhao Lin , Xinyu Zha , Peiyi Han , Chuanyi Liu

Recently, powerful Large Language Models (LLMs) have become easily accessible to hundreds of millions of users world-wide. However, their strong capabilities and vast world knowledge do not come without associated privacy risks. In this…

Machine Learning · Computer Science 2024-11-05 Hanna Yukhymenko , Robin Staab , Mark Vero , Martin Vechev

With the increasing prevalence of mental health conditions worldwide, AI-powered chatbots and conversational agents have emerged as accessible tools to support mental health. However, deploying Large Language Models (LLMs) in mental…

Computation and Language · Computer Science 2026-01-27 Nobin Sarwar

The increasing use of synthetic data generated by Large Language Models (LLMs) presents both opportunities and challenges in data-driven applications. While synthetic data provides a cost-effective, scalable alternative to real-world data…

Computation and Language · Computer Science 2025-07-25 Tevin Atwal , Chan Nam Tieu , Yefeng Yuan , Zhan Shi , Yuhong Liu , Liang Cheng

Large Language Models (LLMs) are increasingly utilized for mental health support; however, current safety benchmarks often fail to detect the complex, longitudinal risks inherent in therapeutic dialogue. We introduce an evaluation framework…

Computation and Language · Computer Science 2026-03-06 Ian Steenstra , Paola Pedrelli , Weiyan Shi , Stacy Marsella , Timothy W. Bickmore

The performance of modern machine learning systems depends on access to large, high-quality datasets, often sourced from user-generated content or proprietary, domain-specific corpora. However, these rich datasets inherently contain…

Cryptography and Security · Computer Science 2025-08-28 Zhan Shi , Yefeng Yuan , Yuhong Liu , Liang Cheng , Yi Fang

Medical question-answering (QA) systems can benefit from advances in large language models (LLMs), but directly applying LLMs to the clinical domain poses challenges such as maintaining factual accuracy and avoiding hallucinations. In this…

Computation and Language · Computer Science 2025-12-08 Tasnimul Hassan , Md Faisal Karim , Haziq Jeelani , Elham Behnam , Robert Green , Fayeq Jeelani Syed

How much information about training samples can be leaked through synthetic data generated by Large Language Models (LLMs)? Overlooking the subtleties of information flow in synthetic data generation pipelines can lead to a false sense of…

Computation and Language · Computer Science 2026-02-13 Matthieu Meeus , Lukas Wutschitz , Santiago Zanella-Béguelin , Shruti Tople , Reza Shokri

The process of matching patients with suitable clinical trials is essential for advancing medical research and providing optimal care. However, current approaches face challenges such as data standardization, ethical considerations, and a…

Computation and Language · Computer Science 2023-08-08 Jiayi Yuan , Ruixiang Tang , Xiaoqian Jiang , Xia Hu

Artificial intelligence (AI) is reshaping modern healthcare by advancing disease diagnosis, treatment decision-making, and biomedical research. Among AI technologies, large language models (LLMs) have become especially impactful, enabling…

Artificial Intelligence · Computer Science 2025-11-18 Zhengda Wang , Daqian Shi , Jingyi Zhao , Xiaolei Diao , Xiongfeng Tang , Yanguo Qin

Health monitoring systems have revolutionized modern healthcare by enabling the continuous capture of physiological and behavioral data, essential for preventive measures and early health intervention. While integrating this data with Large…

Machine Learning · Computer Science 2024-06-26 Ajan Subramanian , Zhongqi Yang , Iman Azimi , Amir M. Rahmani

Large language models (LLMs) have demonstrated significant success in various domain-specific tasks, with their performance often improving substantially after fine-tuning. However, fine-tuning with real-world data introduces privacy risks.…

Cryptography and Security · Computer Science 2025-01-30 Atilla Akkus , Masoud Poorghaffar Aghdam , Mingjie Li , Junjie Chu , Michael Backes , Yang Zhang , Sinem Sav

Large language models (LLMs) in biomedicine face a fundamental conflict between static parameter knowledge and the dynamic nature of clinical evidence. Retrieval-Augmented Generation (RAG) addresses this by grounding generation in external…

Other Quantitative Biology · Quantitative Biology 2025-12-19 Jiawei He , Boya Zhang , Hossein Rouhizadeh , Yingjian Chen , Rui Yang , Jin Lu , Xudong Chen , Nan Liu , Douglas Teodoro

The success of large language models (LLMs) facilitate many parties to fine-tune LLMs on their own private data. However, this practice raises privacy concerns due to the memorization of LLMs. Existing solutions, such as utilizing synthetic…

Cryptography and Security · Computer Science 2024-10-11 Wenhao Wang , Xiaoyu Liang , Rui Ye , Jingyi Chai , Siheng Chen , Yanfeng Wang

Mental health disorders affect over one-fifth of adults globally, yet detecting such conditions from text remains challenging due to the subtle and varied nature of symptom expression. This study evaluates multiple approaches for mental…

Computation and Language · Computer Science 2025-12-23 Mihael Arcan , David-Paul Niland