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Data privacy is a critical challenge in modern medical workflows as the adoption of electronic patient records has grown rapidly. Stringent data protection regulations limit access to clinical records for training and integrating machine…

Synthetic data generation with Large Language Models (LLMs) has emerged as a promising solution in the medical domain to mitigate data scarcity and privacy constraints. However, existing approaches remain constrained by their derivative…

Artificial Intelligence · Computer Science 2026-01-07 Yunghwei Lai , Ziyue Wang , Weizhi Ma , Yang Liu

Large language models (LLMs) have shown promise for mental health support, yet training such models is constrained by the scarcity and sensitivity of real counseling dialogues. In this article, we present MindChat, a privacy-preserving LLM…

Artificial Intelligence · Computer Science 2026-01-27 Dong Xue , Jicheng Tu , Ming Wang , Xin Yan , Fangzhou Liu , Jie Hu

The development of robust clinical decision support systems is frequently impeded by the scarcity of high-fidelity, privacy-preserving biomedical data. While Generative Large Language Models (LLMs) offer a promising avenue for synthetic…

Machine Learning · Computer Science 2026-04-03 Arshia Ilaty , Hossein Shirazi , Amir Rahmani , Hajar Homayouni

An important issue impacting healthcare is a lack of available experts. Machine learning (ML) models could resolve this by aiding in diagnosing patients. However, creating datasets large enough to train these models is expensive. We…

Computation and Language · Computer Science 2024-05-14 Chancellor R. Woolsey , Prakash Bisht , Joshua Rothman , Gondy Leroy

The recent availability of electronic health records (EHRs) have provided enormous opportunities to develop artificial intelligence (AI) algorithms. However, patient privacy has become a major concern that limits data sharing across…

Machine Learning · Computer Science 2023-02-01 Jin Li , Benjamin J. Cairns , Jingsong Li , Tingting Zhu

Recent advancements in large language models (LLMs) have led to the development of highly potent models like OpenAI's ChatGPT. These models have exhibited exceptional performance in a variety of tasks, such as question answering, essay…

Computation and Language · Computer Science 2023-04-12 Ruixiang Tang , Xiaotian Han , Xiaoqian Jiang , Xia Hu

Preservation of private user data is of paramount importance for high Quality of Experience (QoE) and acceptability, particularly with services treating sensitive data, such as IT-based health services. Whereas anonymization techniques were…

Machine Learning · Computer Science 2024-03-04 Navid Ashrafi , Vera Schmitt , Robert P. Spang , Sebastian Möller , Jan-Niklas Voigt-Antons

Synthetic data from generative models emerges as the privacy-preserving data sharing solution. Such a synthetic data set shall resemble the original data without revealing identifiable private information. Till date, the prior focus on…

Machine Learning · Computer Science 2025-07-23 Chaoyi Zhu , Jiayi Tang , Juan F. Pérez , Marten van Dijk , Lydia Y. Chen

While data sharing is crucial for knowledge development, privacy concerns and strict regulation (e.g., European General Data Protection Regulation (GDPR)) unfortunately limits its full effectiveness. Synthetic tabular data emerges as an…

Machine Learning · Computer Science 2021-08-24 Aditya Kunar

Synthetic data generation, a cornerstone of Generative Artificial Intelligence, promotes a paradigm shift in data science by addressing data scarcity and privacy while enabling unprecedented performance. As synthetic data becomes more…

Machine Learning · Statistics 2024-03-12 Xiaotong Shen , Yifei Liu , Rex Shen

Tabular data is one of the most prevalent and important data formats in real-world applications such as healthcare, finance, and education. However, its effective use in machine learning is often constrained by data scarcity, privacy…

Machine Learning · Computer Science 2025-07-18 Ruxue Shi , Yili Wang , Mengnan Du , Xu Shen , Yi Chang , Xin Wang

Machine learning (ML) models frequently rely on training data that may include sensitive or personal information, raising substantial privacy concerns. Legislative frameworks such as the General Data Protection Regulation (GDPR) and the…

Machine Learning · Computer Science 2024-12-31 Md Mahadi Hasan Nahid , Sadid Bin Hasan

The continued promise of Large Language Models (LLMs), particularly in their natural language understanding and generation capabilities, has driven a rapidly increasing interest in identifying and developing LLM use cases. In an effort to…

Cryptography and Security · Computer Science 2026-01-08 Andreea-Elena Bodea , Stephen Meisenbacher , Alexandra Klymenko , Florian Matthes

Machine Learning (ML) in low-data settings remains an underappreciated yet crucial problem. Hence, data augmentation methods to increase the sample size of datasets needed for ML are key to unlocking the transformative potential of ML in…

Machine Learning · Computer Science 2024-07-02 Nabeel Seedat , Nicolas Huynh , Boris van Breugel , Mihaela van der Schaar

Passively collected behavioral health data from ubiquitous sensors holds significant promise to provide mental health professionals insights from patient's daily lives; however, developing analysis tools to use this data in clinical…

Privacy represents one of the most critical yet underaddressed barriers to AI adoption in mental healthcare -- particularly in high-sensitivity operational environments such as military, correctional, and remote healthcare settings, where…

Synthetic data offers a promising path to train models while preserving data privacy. Differentially private (DP) finetuning of large language models (LLMs) as data generator is effective, but is impractical when computation resources are…

Computation and Language · Computer Science 2025-07-18 Bowen Tan , Zheng Xu , Eric Xing , Zhiting Hu , Shanshan Wu

Healthcare research and development face significant obstacles due to data scarcity and stringent privacy regulations, such as HIPAA and the GDPR, restricting access to essential real-world medical data. These limitations impede innovation,…

Machine Learning · Computer Science 2025-10-17 Md Ibrahim Shikder Mahin , Md Shamsul Arefin , Md Tanvir Hasan

Training generative machine learning models to produce synthetic tabular data has become a popular approach for enhancing privacy in data sharing. As this typically involves processing sensitive personal information, releasing either the…

Cryptography and Security · Computer Science 2026-02-02 Georgi Ganev , Emiliano De Cristofaro