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While large language models are capable diagnostic tools, the impact of multi-agent topology on diagnostic accuracy remains underexplored. This study evaluates four agent topologies, Control (single agent), Hierarchical, Adversarial, and…

Multiagent Systems · Computer Science 2026-03-10 Ahmed Almasoud

Deep research agents autonomously conduct open-ended investigations, integrating complex information retrieval with multi-step reasoning across diverse sources to solve real-world problems. To sustain this capability on long-horizon tasks,…

Computation and Language · Computer Science 2026-03-31 Bin Zhu , Qianghuai Jia , Tian Lan , Junyang Ren , Feng Gu , Feihu Jiang , Longyue Wang , Zhao Xu , Weihua Luo

The efficacy of AI agents in healthcare research is hindered by their reliance on static, predefined strategies. This creates a critical limitation: agents can become better tool-users but cannot learn to become better strategic planners, a…

Artificial Intelligence · Computer Science 2025-08-08 Huiya Zhao , Yinghao Zhu , Zixiang Wang , Yasha Wang , Junyi Gao , Liantao Ma

Clinical expertise improves not only by acquiring medical knowledge, but by accumulating experience that yields reusable diagnostic patterns. Recent LLMs-based diagnostic agents have shown promising progress in clinical reasoning for…

Computation and Language · Computer Science 2026-04-09 Bingxuan Li , Simo Du , Yue Guo

AI agents deployed as persistent assistants must maintain correct beliefs as their information environment evolves. In practice, evidence is scattered across heterogeneous sources that often contradict one another, new information can…

Machine Learning · Computer Science 2026-05-19 Haonian Ji , Kaiwen Xiong , Siwei Han , Peng Xia , Shi Qiu , Yiyang Zhou , Jiaqi Liu , Jinlong Li , Bingzhou Li , Zeyu Zheng , Cihang Xie , Huaxiu Yao

Chest X-ray (CXR) interpretation is a fundamental yet complex clinical task that increasingly relies on artificial intelligence for automation. However, traditional monolithic models often lack the nuanced reasoning required for trustworthy…

Computer Vision and Pattern Recognition · Computer Science 2026-04-06 Shawn Young , Lijian Xu

Increasing a ML model accuracy is not enough, we must also increase its trustworthiness. This is an important step for building resilient AI systems for safety-critical applications such as automotive, finance, and healthcare. For that…

Artificial Intelligence · Computer Science 2022-05-03 Gusseppe Bravo-Rocca , Peini Liu , Jordi Guitart , Ajay Dholakia , David Ellison , Miroslav Hodak

Large language models (LLMs) show promise for extracting information from Electronic Health Records (EHR) and supporting clinical decisions. However, deployment in clinical settings faces challenges due to hallucination risks. We propose…

Artificial Intelligence · Computer Science 2025-08-27 Yongwoo Song , Minbyul Jeong , Mujeen Sung

Motivated by the challenge to improve the adversarial robustness, security, and trust of medical decision making intelligent agents, this study develops a full-link security enhancement framework, which describes "input risk perception -…

Cryptography and Security · Computer Science 2026-05-12 Saisai Hu

Human-in-the-loop validation is essential in safety-critical clinical AI, yet the transition between initial model inference and expert correction is rarely analyzed as a structured signal. We introduce a diagnostic alignment framework in…

Artificial Intelligence · Computer Science 2026-02-27 Dimitrios P. Panagoulias , Evangelia-Aikaterini Tsichrintzi , Georgios Savvidis , Evridiki Tsoureli-Nikita

Foundation models are becoming valuable tools in medicine. Yet despite their promise, the best way to leverage Large Language Models (LLMs) in complex medical tasks remains an open question. We introduce a novel multi-agent framework, named…

Computation and Language · Computer Science 2024-10-31 Yubin Kim , Chanwoo Park , Hyewon Jeong , Yik Siu Chan , Xuhai Xu , Daniel McDuff , Hyeonhoon Lee , Marzyeh Ghassemi , Cynthia Breazeal , Hae Won Park

In modern medicine, clinical diagnosis relies on the comprehensive analysis of primarily textual and visual data, drawing on medical expertise to ensure systematic and rigorous reasoning. Recent advances in large Vision-Language Models…

Artificial Intelligence · Computer Science 2025-07-03 Ziyue Wang , Junde Wu , Linghan Cai , Chang Han Low , Xihong Yang , Qiaxuan Li , Yueming Jin

Autonomous agents based on large language models (LLMs) are rapidly evolving to handle multi-turn tasks, but ensuring their trustworthiness remains a critical challenge. A fundamental pillar of this trustworthiness is calibration, which…

Computation and Language · Computer Science 2026-01-13 Weihao Xuan , Qingcheng Zeng , Heli Qi , Yunze Xiao , Junjue Wang , Naoto Yokoya

PET theranostics is transforming precision oncology, yet treatment response varies substantially; many patients receiving 177Lu-PSMA radioligand therapy (RLT) for metastatic castration-resistant prostate cancer (mCRPC) fail to respond,…

The integration of large language models (LLMs) into healthcare IoT systems promises faster decisions and improved medical support. LLMs are also deployed as multi-agent teams to assist AI doctors by debating, voting, or advising on…

Cryptography and Security · Computer Science 2025-12-04 Adeela Bashir , The Anh han , Zia Ush Shamszaman

Verifiers--functions assigning rewards to agent behavior--have been key to AI progress in math, code, and games. However, extending gains to domains without clear-cut success criteria remains a challenge: while humans can recognize desired…

Artificial Intelligence · Computer Science 2026-03-10 Moises Andrade , Joonhyuk Cha , Brandon Ho , Vriksha Srihari , Karmesh Yadav , Zsolt Kira

Aligning large language models (LLMs) with human values is a central challenge for ensuring trustworthy and safe deployment. While existing methods such as Reinforcement Learning from Human Feedback (RLHF) and its variants have improved…

Multiagent Systems · Computer Science 2026-03-13 Yuanhong Wu , Djallel Bouneffouf , D. Frank Hsu

Matching patients effectively and efficiently for clinical trials is a significant challenge due to the complexity and variability of patient profiles and trial criteria. This paper introduces \textbf{Multi-Agent for Knowledge Augmentation…

Multiagent Systems · Computer Science 2026-05-19 Hanwen Shi , Jin Zhang , Kunpeng Zhang

Large language models (LLMs) are increasingly grounded in sensor data to perceive and reason about human physiology and the physical world. However, accurately interpreting heterogeneous multimodal sensor data remains a fundamental…

Artificial Intelligence · Computer Science 2026-01-13 Hyungjun Yoon , Mohammad Malekzadeh , Sung-Ju Lee , Fahim Kawsar , Lorena Qendro

Background: Agent skills are increasingly deployed as modular, reusable capability units in AI agent systems. Medical research agent skills require safeguards beyond general-purpose evaluation, including scientific integrity, methodological…

Artificial Intelligence · Computer Science 2026-04-23 Yingyong Hou , Xinyuan Lao , Huimei Wang , Qianyu Yao , Wei Chen , Bocheng Huang , Fei Sun , Yuxian Lv , Weiqi Lei , Xueqian Wen , Pengfei Xia , Zhujun Tan , Shengyang Xie