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Evidence to guide healthcare decisions is often limited by a lack of relevant and trustworthy literature as well as difficulty in contextualizing existing research for a specific patient. Large language models (LLMs) could potentially…

Clinical problem-solving requires processing of semantic medical knowledge such as illness scripts and numerical medical knowledge of diagnostic tests for evidence-based decision-making. As large language models (LLMs) show promising…

Pre-consultation is a critical component of effective healthcare delivery. However, generating comprehensive pre-consultation questionnaires from complex, voluminous Electronic Medical Records (EMRs) is a challenging task. Direct Large…

Artificial Intelligence · Computer Science 2025-08-04 Ruiqing Ding , Qianfang Sun , Yongkang Leng , Hui Yin , Xiaojian Li

This study evaluates the capacity of large language models (LLMs) to generate structured clinical consultation templates for electronic consultation. Using 145 expert-crafted templates developed and routinely used by Stanford's eConsult…

Clinical Question Answering (QA) systems enable doctors to quickly access patient information from electronic health records (EHRs). However, training these systems requires significant annotated data, which is limited due to the expertise…

Computation and Language · Computer Science 2024-12-09 Fan Bai , Keith Harrigian , Joel Stremmel , Hamid Hassanzadeh , Ardavan Saeedi , Mark Dredze

The growing use of large language models (LLMs) for biomedical question answering raises concerns about the accuracy and evidentiary support of their responses. To address this, we present Answered with Evidence, a framework for evaluating…

Machine Learning · Computer Science 2025-07-08 Julian D Baldwin , Christina Dinh , Arjun Mukerji , Neil Sanghavi , Saurabh Gombar

Accurate and efficient question-answering systems are essential for delivering high-quality patient care in the medical field. While Large Language Models (LLMs) have made remarkable strides across various domains, they continue to face…

Computation and Language · Computer Science 2025-01-22 Hang Yang , Hao Chen , Hui Guo , Yineng Chen , Ching-Sheng Lin , Shu Hu , Jinrong Hu , Xi Wu , Xin Wang

Evidence-based medicine (EBM) plays a crucial role in the application of large language models (LLMs) in healthcare, as it provides reliable support for medical decision-making processes. Although it benefits from current…

Computation and Language · Computer Science 2025-03-24 Chengfeng Dou , Ying Zhang , Zhi Jin , Wenpin Jiao , Haiyan Zhao , Yongqiang Zhao , Zhengwei Tao

Large Language Models (LLMs) have exhibited remarkable capabilities in clinical scenarios. Despite their potential, existing works face challenges when applying LLMs to medical settings. Strategies relying on training with medical datasets…

Computation and Language · Computer Science 2025-10-10 Keer Lu , Zheng Liang , Da Pan , Shusen Zhang , Guosheng Dong , Zhonghai Wu , Huang Leng , Bin Cui , Wentao Zhang

When addressing professional questions in the biomedical domain, humans typically acquire multiple pieces of information as evidence and engage in multifaceted analysis to provide high-quality answers. Current LLM-based question answering…

Computation and Language · Computer Science 2025-09-03 Chang Zong , Jian Wan , Siliang Tang , Lei Zhang

Large Language Models (LLMs) have demonstrated substantial progress in biomedical and clinical applications, motivating rigorous evaluation of their ability to answer nuanced, evidence-based questions. We curate a multi-source benchmark…

Computation and Language · Computer Science 2025-09-16 Can Wang , Yiqun Chen

Large Language Models (LLMs), such as ChatGPT, have recently been applied to various NLP tasks due to its open-domain generation capabilities. However, there are two issues with applying LLMs to dialogue tasks. 1. During the dialogue…

Computation and Language · Computer Science 2023-10-06 Siwei Wu , Xiangqing Shen , Rui Xia

Generative Large Language Models (LLMs) hold significant promise in healthcare, demonstrating capabilities such as passing medical licensing exams and providing clinical knowledge. However, their current use as information retrieval tools…

The recent success of Large Language Models (LLMs) has had a significant impact on the healthcare field, providing patients with medical advice, diagnostic information, and more. However, due to a lack of professional medical knowledge,…

Computation and Language · Computer Science 2024-06-27 Wenya Xie , Qingying Xiao , Yu Zheng , Xidong Wang , Junying Chen , Ke Ji , Anningzhe Gao , Xiang Wan , Feng Jiang , Benyou Wang

This paper surveys the development of large language model (LLM)-based agents for question answering (QA). Traditional agents face significant limitations, including substantial data requirements and difficulty in generalizing to new…

Computation and Language · Computer Science 2025-03-26 Murong Yue

Large Language Models (LLMs) have demonstrated remarkable performance across various information-seeking and reasoning tasks. These computational systems drive state-of-the-art dialogue systems, such as ChatGPT and Bard. They also carry…

Computation and Language · Computer Science 2023-10-13 Siyuan Brandon Loh , Aravind Sesagiri Raamkumar

Evidence-based medicine (EBM) holds a crucial role in clinical application. Given suitable medical articles, doctors effectively reduce the incidence of misdiagnoses. Researchers find it efficient to use large language models (LLMs)…

Computation and Language · Computer Science 2025-11-07 Mengzhou Sun , Sendong Zhao , Jianyu Chen , Haochun Wang , Bing Qin

The severe shortage of medical doctors limits access to timely and reliable healthcare, leaving millions underserved. Large language models (LLMs) offer a potential solution but struggle in real-world clinical interactions. Many LLMs are…

Computation and Language · Computer Science 2026-05-11 Jiayuan Zhu , Jiazhen Pan , Yuyuan Liu , Fenglin Liu , Junde Wu

Objective: This study investigates the potential of Large Language Models (LLMs) as an alternative to human expert elicitation for extracting structured causal knowledge and facilitating causal modeling in biometric and healthcare…

Artificial Intelligence · Computer Science 2025-04-15 Olha Shaposhnyk , Daria Zahorska , Svetlana Yanushkevich

We evaluate questions generated by large language models (LLMs) from context, comparing them to human-authored questions across six dimensions: question type, question length, context coverage, answerability, uncommonness, and required…

Computation and Language · Computer Science 2025-06-19 Yueheng Zhang , Xiaoyuan Liu , Yiyou Sun , Atheer Alharbi , Hend Alzahrani , Tianneng Shi , Basel Alomair , Dawn Song
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