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The increasing demand for mental health services has outpaced the availability of real training data to develop clinical professionals, leading to limited support for the diagnosis of depression. This shortage has motivated the development…

Computation and Language · Computer Science 2025-08-07 Xi Wang , Anxo Perez , Javier Parapar , Fabio Crestani

Doctor-patient consultations require multi-turn, context-aware communication tailored to diverse patient personas. Training or evaluating doctor LLMs in such settings requires realistic patient interaction systems. However, existing…

Artificial Intelligence · Computer Science 2025-10-30 Daeun Kyung , Hyunseung Chung , Seongsu Bae , Jiho Kim , Jae Ho Sohn , Taerim Kim , Soo Kyung Kim , Edward Choi

Simulating human clients in mental health counseling is crucial for training and evaluating counselors (both human or simulated) in a scalable manner. Nevertheless, past research on client simulation did not focus on complex conversation…

Problem: Effective patient-centered communication is a core competency for physicians. However, both seasoned providers and medical trainees report decreased confidence in leading conversations on sensitive topics such as goals of care or…

Human-Computer Interaction · Computer Science 2024-05-31 Simon N. Chu , Alex J. Goodell

Simulation is a powerful tool for exploring uncertainty. Its potential in clinical medicine is transformative and includes personalized treatment planning and virtual clinical trials. However, simulating patient trajectories is challenging…

Artificial Intelligence · Computer Science 2026-01-27 Yu Akagi , Tomohisa Seki , Hiromasa Ito , Toru Takiguchi , Kazuhiko Ohe , Yoshimasa Kawazoe

An effective healthcare agent must be able to recall and reason over a patient's longitudinal medical history. However, the absence of datasets with realistic long-term dialogue timelines limits systematic evaluation. Real clinical text is…

Computation and Language · Computer Science 2026-05-20 Hebin Hu , Renke Dai , Ah-Hwee Tan , Yilin Kang

Synthetic data adoption in healthcare is driven by privacy concerns, data access limitations, and high annotation costs. We explore synthetic Prolonged Exposure (PE) therapy conversations for PTSD as a scalable alternative for training…

Computation and Language · Computer Science 2025-09-23 Suhas BN , Dominik Mattioli , Saeed Abdullah , Rosa I. Arriaga , Chris W. Wiese , Andrew M. Sherrill

As Large Language Models increasingly power role-playing applications, simulating patients has become a valuable tool for training counselors and scaling therapeutic assessment. However, prior work is fragmented: existing approaches rely on…

Computation and Language · Computer Science 2026-02-13 Sahand Sabour , TszYam NG , Minlie Huang

The simulation of realistic clinical interactions plays a pivotal role in advancing clinical Large Language Models (LLMs) and supporting medical diagnostic education. Existing approaches and benchmarks rely on generic or LLM-generated…

Computation and Language · Computer Science 2026-01-19 Shijie Jiang , Zefan Zhang , Kehua Zhu , Tian Bai , Ruihong Zhao

Data scarcity and unreliable self-reporting -- such as concealment or exaggeration -- pose fundamental challenges to psychiatric intake and assessment. We propose a multi-agent synthesis framework that explicitly models patient deception to…

Databases · Computer Science 2026-01-15 Xinyuan Zhang , Zijian Wang , Chang Dao , Juexiao Zhou

The psychological profile that structurally documents the case of a depression patient is essential for psychotherapy. Large language models can be applied to summarize the profiles from counseling speech, however, it may suffer from…

Sound · Computer Science 2026-04-14 Xingjian Yang , Yudong Yang , Zhixing Guo , Yongjie Zhou , Nan Yan , Lan Wang

Training medical personnel using standardized patients (SPs) remains a complex challenge, requiring extensive domain expertise and role-specific practice. Previous research on Large Language Model (LLM)-based SPs mostly focuses on improving…

Computation and Language · Computer Science 2025-06-10 Zhuoyun Du , Lujie Zheng , Renjun Hu , Yuyang Xu , Xiawei Li , Ying Sun , Wei Chen , Jian Wu , Haolei Cai , Haohao Ying

Training mental health clinicians to conduct standardized clinical assessments is challenging due to a lack of scalable, realistic practice opportunities, which can impact data quality in clinical trials. To address this gap, we introduce a…

Human-Computer Interaction · Computer Science 2025-12-30 Veronica Bossio Botero , Vijay Yadav , Jacob Ouyang , Anzar Abbas , Michelle Worthington

Synthetic data generation with Large Language Models (LLMs) has emerged as a promising solution in the medical domain to mitigate data scarcity and privacy constraints. However, existing approaches remain constrained by their derivative…

Artificial Intelligence · Computer Science 2026-01-07 Yunghwei Lai , Ziyue Wang , Weizhi Ma , Yang Liu

Since the COVID-19 pandemic, clinicians have seen a large and sustained influx in patient portal messages, significantly contributing to clinician burnout. To the best of our knowledge, there are no large-scale public patient portal…

Artificial Intelligence · Computer Science 2024-11-12 Joseph Gatto , Parker Seegmiller , Timothy E. Burdick , Sarah Masud Preum

Background: We present a Patient Simulator that leverages real world patient encounters which cover a broad range of conditions and symptoms to provide synthetic test subjects for development and testing of healthcare agentic models. The…

Computation and Language · Computer Science 2025-06-05 Sina Rashidian , Nan Li , Jonathan Amar , Jong Ha Lee , Sam Pugh , Eric Yang , Geoff Masterson , Myoung Cha , Yugang Jia , Akhil Vaid

Digital footprints (records of individuals' interactions with digital systems) are essential for studying behavior, developing personalized applications, and training machine learning models. However, research in this area is often hindered…

Computation and Language · Computer Science 2026-03-13 Minjia Wang , Yunfeng Wang , Xiao Ma , Dexin Lv , Qifan Guo , Lynn Zheng , Benliang Wang , Lei Wang , Jiannan Li , Yongwei Xing , David Xu , Zheng Sun

We present an end-to-end framework for generating synthetic users for evaluating interactive agents designed to encourage positive behavior changes, such as in health and lifestyle coaching. The synthetic users are grounded in health and…

Mental illness remains one of the most critical public health issues. Despite its importance, many mental health professionals highlight a disconnect between their training and actual real-world patient practice. To help bridge this gap, we…

LLM-based client simulation has emerged as a promising tool for training novice counselors and evaluating automated counseling systems. However, existing client simulation approaches face three key challenges: (1) limited diversity and…

Computation and Language · Computer Science 2026-01-13 Huachuan Qiu , Zhaoming Chen , Yuqian Chen , Yuan Xie , Yu Lu , Zhenzhong Lan
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