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Spatial transcriptomics (ST) is essential for understanding diseases and developing novel treatments. It measures gene expression of each fine-grained area (i.e., different windows) in the tissue slide with low throughput. This paper…

Computer Vision and Pattern Recognition · Computer Science 2022-11-01 Yan Yang , Md Zakir Hossain , Eric A Stone , Shafin Rahman

Spatial transcriptomics (ST) maps gene expression within tissue at individual spots, making it a valuable resource for multimodal representation learning. Additionally, ST inherently contains rich hierarchical information both across and…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Xulin Chen , Junzhou Huang

Recent advancements in Spatial Transcriptomics (ST) technology have facilitated detailed gene expression analysis within tissue contexts. However, the high costs and methodological limitations of ST necessitate a more robust predictive…

Computer Vision and Pattern Recognition · Computer Science 2024-04-26 Youngmin Chung , Ji Hun Ha , Kyeong Chan Im , Joo Sang Lee

Representation learning is a fundamental but challenging problem, especially when the distribution of data is unknown. We propose a new representation learning method, termed Structure Transfer Machine (STM), which enables feature learning…

Machine Learning · Computer Science 2019-08-06 Baochang Zhang , Lian Zhuo , Ze Wang , Jungong Han , Xiantong Zhen

Spatial studies of transcriptome provide biologists with gene expression maps of heterogeneous and complex tissues. However, most experimental protocols for spatial transcriptomics suffer from the need to select beforehand a small fraction…

Machine Learning · Computer Science 2019-05-08 Romain Lopez , Achille Nazaret , Maxime Langevin , Jules Samaran , Jeffrey Regier , Michael I. Jordan , Nir Yosef

It has always been a big challenge to identify subtle changes in Electroencephalogram (EEG) signals. Minor differences often lead to vital decisions, for example, which grade a certain tumour belong to or whether a haemorrhage can result in…

Systems and Control · Electrical Eng. & Systems 2022-06-01 Debojyoti Seth

Spatial Transcriptomics (ST) profiles thousands of gene expression values at discrete spots with precise coordinates on tissue sections, preserving spatial context essential for clinical and pathological studies. With rising sequencing…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Yishun Zhu , Jiaxin Qi , Jian Wang , Yuhua Zheng , Jianqiang Huang

Higher-order tensors have received increased attention across science and engineering. While most tensor decomposition methods are developed for a single tensor observation, scientific studies often collect side information, in the form of…

Methodology · Statistics 2021-10-29 Jiaxin Hu , Chanwoo Lee , Miaoyan Wang

Spatial transcriptomics (ST) technologies enable transcriptome-wide gene expression profiling while preserving spatial resolution, offering unprecedented opportunities to uncover complex spatial structures. Due to the ultra-high…

Applications · Statistics 2026-03-11 Changhu Wang , Qiyun Huang , Zihao Chen , Jin Liu , Ruibin Xi

The rapid adoption of synthetic data for training Large Language Models (LLMs) has introduced the technical challenge of "model collapse"-a degenerative process where recursive training on model-generated content leads to a contraction of…

Machine Learning · Computer Science 2026-03-24 Yi Gu , Lingyou Pang , Xiangkun Ye , Tianyu Wang , Jianyu Lin , Carey E. Priebe , Alexander Aue

Spatial transcriptomics technologies enable the measurement of gene expression with spatial context, providing opportunities to understand how gene regulatory networks vary across tissue regions. However, existing graphical models focus…

Methodology · Statistics 2025-12-15 Trisha Dawn , Yang Ni

Handling sparse and unstructured geometric data, such as point clouds or event-based vision, is a pressing challenge in the field of machine vision. Recently, sequence models such as Transformers and state-space models entered the domain of…

Computer Vision and Pattern Recognition · Computer Science 2024-11-25 Mark Schöne , Yash Bhisikar , Karan Bania , Khaleelulla Khan Nazeer , Christian Mayr , Anand Subramoney , David Kappel

Low-rank matrix approximation (LRMA) is a powerful technique for signal processing and pattern analysis. However, its potential for data compression has not yet been fully investigated in the literature. In this paper, we propose sparse…

Multimedia · Computer Science 2016-02-22 Junhui Hou , Lap-Pui Chau , Nadia Magnenat-Thalmann , Ying He

SLAM (Simultaneous Localisation and Mapping) is a crucial component for robotic systems, providing a map of an environment, the current location and previous trajectory of a robot. While 3D LiDAR SLAM has received notable improvements in…

Robotics · Computer Science 2025-04-29 Leon Davies , Baihua Li , Mohamad Saada , Simon Sølvsten , Qinggang Meng

Performing simultaneous localization and mapping (SLAM) in low-visibility conditions, such as environments filled with smoke, dust and transparent objets, has long been a challenging task. Sensors like cameras and Light Detection and…

Robotics · Computer Science 2024-12-24 Fuhua Jia , Xiaoying Yang , Mengshen Yang , Yang Li , Hang Xu , Adam Rushworth , Salman Ijaz , Heng Yu , Tianxiang Cui

Spatial Transcriptomics (ST) reveals the spatial distribution of gene expression in tissues, offering critical insights into biological processes and disease mechanisms. However, the high cost, limited coverage, and technical complexity of…

Computer Vision and Pattern Recognition · Computer Science 2025-04-22 Yi Niu , Jiashuai Liu , Yingkang Zhan , Jiangbo Shi , Di Zhang , Marika Reinius , Ines Machado , Mireia Crispin-Ortuzar , Jialun Wu , Chen Li , Zeyu Gao

Single-cell-resolution spatial transcriptomics profiles gene expression at cellular locations in native tissues, yet accurate cell-type annotation remains challenging: imaging-based platforms are constrained by targeted gene panels, whereas…

Cell Behavior · Quantitative Biology 2026-05-27 Yiyang Zhang , Bokai Zhao , Xiaoru Zhang , Zongchang Du , Xiaojuan Sun , Tianzi Jiang

This paper explores adaptive variance reduction methods for stochastic optimization based on the STORM technique. Existing adaptive extensions of STORM rely on strong assumptions like bounded gradients and bounded function values, or suffer…

Optimization and Control · Mathematics 2024-10-24 Wei Jiang , Sifan Yang , Yibo Wang , Lijun Zhang

Spatial transcriptomics enables spatial gene expression profiling, motivating computational models that capture spatially conditioned regulatory relationships. We introduce SAGE-FM, a lightweight spatial transcriptomics foundation model…

Machine Learning · Computer Science 2026-01-23 Xianghao Zhan , Jingyu Xu , Yuanning Zheng , Zinaida Good , Olivier Gevaert

Spectral clustering and co-clustering are well-known techniques in data analysis, and recent work has extended spectral clustering to square, symmetric tensors and hypermatrices derived from a network. We develop a new tensor spectral…

Social and Information Networks · Computer Science 2016-03-02 Tao Wu , Austin R. Benson , David F. Gleich
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