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Each year, hundreds of clinical trials are conducted to evaluate new medical interventions, but sharing patient records from these trials with other institutions can be challenging due to privacy concerns and federal regulations. To help…

Machine Learning · Computer Science 2025-02-19 Trisha Das , Zifeng Wang , Afrah Shafquat , Mandis Beigi , Jason Mezey , Jacob Aptekar , Jimeng Sun

Difficult-to-treat depression (DTD) has been proposed as a broader and more clinically comprehensive perspective on a person's depressive disorder where despite treatment, they continue to experience significant burden. We sought to develop…

Computation and Language · Computer Science 2024-02-13 Isabelle Lorge , Dan W. Joyce , Niall Taylor , Alejo Nevado-Holgado , Andrea Cipriani , Andrey Kormilitzin

Synthetic data sets are used across linguistic domains and NLP tasks, particularly in scenarios where authentic data is limited (or even non-existent). One such domain is that of clinical (healthcare) contexts, where there exist significant…

Computation and Language · Computer Science 2026-03-17 Steven Bedrick , A. Seza Doğruöz , Sergiu Nisioi

Accurate and comprehensive clinical documentation is crucial for delivering high-quality healthcare, facilitating effective communication among providers, and ensuring compliance with regulatory requirements. However, manual transcription…

Computation and Language · Computer Science 2024-06-12 Anjanava Biswas , Wrick Talukdar

Clinical information extraction, which involves structuring clinical concepts from unstructured medical text, remains a challenging problem that could benefit from the inclusion of tabular background information available in electronic…

Artificial Intelligence · Computer Science 2025-12-10 Paloma Rabaey , Stefan Heytens , Thomas Demeester

Synthetic data generation has the potential to impact applications and domains with scarce data. However, before such data is used for sensitive tasks such as mental health, we need an understanding of how different demographics are…

Artificial Intelligence · Computer Science 2024-03-26 Shinka Mori , Oana Ignat , Andrew Lee , Rada Mihalcea

Artificial Intelligence and digital health have the potential to transform global health. However, having access to representative data to test and validate algorithms in realistic production environments is essential. We introduce…

Ensuring the generalisability of clinical machine learning (ML) models across diverse healthcare settings remains a significant challenge due to variability in patient demographics, disease prevalence, and institutional practices. Existing…

Machine Learning · Computer Science 2025-04-30 Bradley Segal , Joshua Fieggen , David Clifton , Lei Clifton

Diffusion models have recently been employed to generate high-quality images, reducing the need for manual data collection and improving model generalization in tasks such as object detection, instance segmentation, and image perception.…

Computer Vision and Pattern Recognition · Computer Science 2024-12-03 You Li , Fan Ma , Yi Yang

The scarcity of high-quality annotated medical data, particularly in mental health, poses a significant bottleneck for training robust machine learning models. Privacy regulations restrict data sharing, making synthetic data generation a…

Medical dialogue systems (MDS) enhance patient-physician communication, improve healthcare accessibility, and reduce costs. However, acquiring suitable data to train these systems poses significant challenges. Privacy concerns prevent the…

Computation and Language · Computer Science 2024-08-13 Trisha Das , Dina Albassam , Jimeng Sun

Synthetic clinical data are increasingly important for advancing AI in healthcare, given strict privacy constraints on real-world EHRs, limited availability of annotated rare-condition data, and systemic biases in observational datasets.…

Machine Learning · Computer Science 2025-09-16 Rumeng Li , Xun Wang , Hong Yu

Recognizing pain in video is crucial for improving patient-computer interaction systems, yet traditional data collection in this domain raises significant ethical and logistical challenges. This study introduces a novel approach that…

Computer Vision and Pattern Recognition · Computer Science 2024-09-26 Jonas Nasimzada , Jens Kleesiek , Ken Herrmann , Alina Roitberg , Constantin Seibold

The increasing use of synthetic data generated by Large Language Models (LLMs) presents both opportunities and challenges in data-driven applications. While synthetic data provides a cost-effective, scalable alternative to real-world data…

Computation and Language · Computer Science 2025-07-25 Tevin Atwal , Chan Nam Tieu , Yefeng Yuan , Zhan Shi , Yuhong Liu , Liang Cheng

Synthetic data generation using large language models (LLMs) demonstrates substantial promise in addressing biomedical data challenges and shows increasing adoption in biomedical research. This study systematically reviews recent advances…

Computation and Language · Computer Science 2026-02-18 Hanshu Rao , Weisi Liu , Haohan Wang , I-Chan Huang , Zhe He , Xiaolei Huang

Large language models (LLMs) hold significant potential for mental health support, capable of generating empathetic responses and simulating therapeutic conversations. However, existing LLM-based approaches often lack the clinical grounding…

Computation and Language · Computer Science 2025-11-04 He Hu , Yucheng Zhou , Juzheng Si , Qianning Wang , Hengheng Zhang , Fuji Ren , Fei Ma , Laizhong Cui , Qi Tian

Physician-physician discussions of patient cases represent a rich source of clinical knowledge and reasoning that could feed AI agents to enrich and even participate in subsequent interactions. However, privacy regulations and ethical…

Computation and Language · Computer Science 2026-04-13 Beny Rubinstein , Sergio Matos

Users of social platforms often perceive these sites as supportive spaces to post about their mental health issues. Those conversations contain important traces about individuals' health risks. Recently, researchers have exploited this…

Computation and Language · Computer Science 2024-08-21 Eliseo Bao , Anxo Pérez , Javier Parapar

Recent advances in deep generative models have greatly expanded the potential to create realistic synthetic health datasets. These synthetic datasets aim to preserve the characteristics, patterns, and overall scientific conclusions derived…

Machine Learning · Computer Science 2024-07-04 Jennifer A Bartell , Sander Boisen Valentin , Anders Krogh , Henning Langberg , Martin Bøgsted

Personalized prompting offers large opportunities for deploying large language models (LLMs) to diverse users, yet existing prompt optimization methods primarily focus on task-level optimization while largely overlooking user-specific…

Machine Learning · Computer Science 2026-02-16 Yuchen Ma , Yue Huang , Wenjie Wang , Xiaonan Luo , Xiangliang Zhang , Stefan Feuerriegel