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Most supervised machine learning tasks are subject to irreducible prediction errors. Probabilistic predictive models address this limitation by providing probability distributions that represent a belief over plausible targets, rather than…

Machine Learning · Statistics 2022-10-25 David Widmann , Fredrik Lindsten , Dave Zachariah

Understanding the complex and stochastic nature of Gene Regulatory Networks (GRNs) remains a central challenge in systems biology. Existing modeling paradigms often struggle to effectively capture the intricate, multi-factor regulatory…

Molecular Networks · Quantitative Biology 2025-08-20 Yiyang Jia , Zheng Wei , Zheng Yang , Guohong Peng

Advances in foundation modeling have reshaped computational pathology. However, the increasing number of available models and lack of standardized benchmarks make it increasingly complex to assess their strengths, limitations, and potential…

Computer Vision and Pattern Recognition · Computer Science 2025-02-11 Andrew Zhang , Guillaume Jaume , Anurag Vaidya , Tong Ding , Faisal Mahmood

In recent years, Predictive Process Mining (PPM) techniques based on artificial neural networks have evolved as a method for monitoring the future behavior of unfolding business processes and predicting Key Performance Indicators (KPIs).…

Deep learning (DL) and machine learning (ML) models have shown promise in drug response prediction (DRP), yet their ability to generalize across datasets remains an open question, raising concerns about their real-world applicability. Due…

Aligning Large Language Models (LLMs) with high-stakes medical standards remains a significant challenge, primarily due to the dissonance between coarse-grained preference signals and the complex, multi-dimensional nature of clinical…

Artificial Intelligence · Computer Science 2026-04-10 He Geng , Yangmin Huang , Lixian Lai , Qianyun Du , Hui Chu , Zhiyang He , Jiaxue Hu , Xiaodong Tao

An RNA-seq experiment with 48 biological replicates in each of 2 conditions was performed to determine the number of biological replicates ($n_r$) required, and to identify the most effective statistical analysis tools for identifying…

The rapid proliferation of benchmarks for evaluating large language models (LLMs) has created an urgent need for systematic methods to assess benchmark quality itself. We propose Benchmark^2, a comprehensive framework comprising three…

Translational medicine turns underspecified development goals into evidence synthesis that must combine literature, trials, patents, and quantitative multi-omics analysis while preserving identifiers, uncertainty, and retrievable…

In many real-world applications of machine learning such as recommendations, hiring, and lending, deployed models influence the data they are trained on, leading to feedback loops between predictions and data distribution. The performative…

Machine Learning · Computer Science 2025-11-18 Kun Jin , Tian Xie , Yang Liu , Xueru Zhang

Biometric systems based on brain activity have been proposed as an alternative to passwords or to complement current authentication techniques. By leveraging the unique brainwave patterns of individuals, these systems offer the possibility…

Cryptography and Security · Computer Science 2024-07-12 Avinash Kumar Chaurasia , Matin Fallahi , Thorsten Strufe , Philipp Terhörst , Patricia Arias Cabarcos

We conducted a systematic literature review on automated grading and feedback tools for programming education. We analysed 121 research papers from 2017 to 2021 inclusive and categorised them based on skills assessed, approach, language…

Software Engineering · Computer Science 2023-12-11 Marcus Messer , Neil C. C. Brown , Michael Kölling , Miaojing Shi

Preference learning is a widely adopted post-training technique that aligns large language models (LLMs) to human preferences and improves specific downstream task capabilities. In this work we systematically investigate how specific…

Computation and Language · Computer Science 2024-12-23 Joongwon Kim , Anirudh Goyal , Aston Zhang , Bo Xiong , Rui Hou , Melanie Kambadur , Dhruv Mahajan , Hannaneh Hajishirzi , Liang Tan

Despite recent advances in AI, the development of systems capable of executing complex, multi-step reasoning tasks involving multiple tools remains a significant challenge. Current benchmarks fall short in capturing the real-world…

Computation and Language · Computer Science 2025-01-03 Vaskar Nath , Pranav Raja , Claire Yoon , Sean Hendryx

Choosing an appropriate strategy for partitioning data into training and evaluation sets is a critical step in machine learning, yet validation methods are often selected using default or conventional settings without considering their…

Machine Learning · Computer Science 2026-01-05 Zahra Bami , Ali Behnampour , Aniruddha Bora , Hassan Doosti

Ensuring consistency between research papers and their corresponding software code implementations is a fundamental prerequisite for guaranteeing the reproducibility of scientific findings and the reliability of software systems. However,…

Machine Learning · Computer Science 2026-05-01 Tianxiang Xu , Xiaoyan Zhu , Xin Lai , Sizhe Dang , Xin Lian , Hangyu Cheng , Jiayin Wang

Embedded Systems combine one or more processor cores with dedicated logic running on an ASIC or FPGA to meet design goals at reasonable cost. It is achieved by profiling the application with variety of aspects like performance, memory…

Performance · Computer Science 2013-12-12 Rajendra Patel , Arvind Rajwat

Tool-integrated reasoning has emerged as a promising paradigm for enhancing large language models with external computation, retrieval, and execution capabilities. However, the field still lacks a high-quality and unified evaluation…

Artificial Intelligence · Computer Science 2026-05-12 Yize Li , Junzhi Li , Jason Song , Chuxiong Sun , Rui Wang , Changwen Zheng

In many high-dimensional prediction or classification tasks, complementary data on the features are available, e.g. prior biological knowledge on (epi)genetic markers. Here we consider tasks with numerical prior information that provide an…

Methodology · Statistics 2022-12-19 Armin Rauschenberger , Zied Landoulsi , Mark A. van de Wiel , Enrico Glaab

In recent years, the growing availability of biomedical datasets featuring numerous longitudinal covariates has motivated the development of several multi-step methods for the dynamic prediction of survival outcomes. These methods employ…

Methodology · Statistics 2026-01-14 Mirko Signorelli , Sophie Retif