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Breast density assessment is a crucial component of mammographic interpretation, with high breast density (BI-RADS categories C and D) representing both a significant risk factor for developing breast cancer and a technical challenge for…

Image and Video Processing · Electrical Eng. & Systems 2025-07-11 Peyman Sharifian , Xiaotong Hong , Alireza Karimian , Mehdi Amini , Hossein Arabi

Real-world categorization is severely hampered by class imbalance because traditional ensembles favor majority classes, which lowers minority performance and overall F1-score. We provide a unique ensemble technique for imbalanced problems…

Computation and Language · Computer Science 2026-04-14 Mohamed Ehab , Ali Hamdi , Khaled Shaban

In real-world clinical settings, data distributions evolve over time, with a continuous influx of new, limited disease cases. Therefore, class incremental learning is of great significance, i.e., deep learning models are required to learn…

Computer Vision and Pattern Recognition · Computer Science 2024-09-13 Yifei Yao , Hanrong Zhang

Cervical cancer is the fourth most common category of cancer, affecting more than 500,000 women annually, owing to the slow detection procedure. Early diagnosis can help in treating and even curing cancer, but the tedious, time-consuming…

Computer Vision and Pattern Recognition · Computer Science 2021-08-24 Rohit Kundu , Hritam Basak , Akhil Koilada , Soham Chattopadhyay , Sukanta Chakraborty , Nibaran Das

Determining lymphoma subtypes is a crucial step for better patient treatment targeting to potentially increase their survival chances. In this context, the existing gold standard diagnosis method, which relies on gene expression technology,…

Image and Video Processing · Electrical Eng. & Systems 2024-07-24 Bilel Guetarni , Feryal Windal , Halim Benhabiles , Marianne Petit , Romain Dubois , Emmanuelle Leteurtre , Dominique Collard

In most real-world scenarios, labeled training datasets are highly class-imbalanced, where deep neural networks suffer from generalizing to a balanced testing criterion. In this paper, we explore a novel yet simple way to alleviate this…

Computer Vision and Pattern Recognition · Computer Science 2020-12-22 Jaehyung Kim , Jongheon Jeong , Jinwoo Shin

Several machine learning techniques for accurate detection of skin cancer from medical images have been reported. Many of these techniques are based on pre-trained convolutional neural networks (CNNs), which enable training the models based…

Computer Vision and Pattern Recognition · Computer Science 2021-05-18 Aqsa Saeed Qureshi , Teemu Roos

The accurate classification of lymphoma subtypes using hematoxylin and eosin (H&E)-stained tissue is complicated by the wide range of morphological features these cancers can exhibit. We present LymphoML - an interpretable machine learning…

Precise breast cancer classification on histopathological images has the potential to greatly improve the diagnosis and patient outcome in oncology. The data imbalance problem largely stems from the inherent imbalance within medical image…

Image and Video Processing · Electrical Eng. & Systems 2024-11-28 Majid Behzadpour , Bengie L. Ortiz , Ebrahim Azizi , Kai Wu

Predictive uncertainty-a model's self awareness regarding its accuracy on an input-is key for both building robust models via training interventions and for test-time applications such as selective classification. We propose a novel…

Machine Learning · Computer Science 2024-01-04 Nishant Jain , Karthikeyan Shanmugam , Pradeep Shenoy

Single-cell datasets often lack individual cell labels, making it challenging to identify cells associated with disease. To address this, we introduce Mixture Modeling for Multiple Instance Learning (MMIL), an expectation maximization…

Quantitative Methods · Quantitative Biology 2024-06-13 Erin Craig , Timothy Keyes , Jolanda Sarno , Maxim Zaslavsky , Garry Nolan , Kara Davis , Trevor Hastie , Robert Tibshirani

Class imbalance is a common problem in medical diagnosis, causing a standard classifier to be biased towards the common classes and perform poorly on the rare classes. This is especially true for dermatology, a specialty with thousands of…

Computer Vision and Pattern Recognition · Computer Science 2020-11-17 Wei-Hung Weng , Jonathan Deaton , Vivek Natarajan , Gamaleldin F. Elsayed , Yuan Liu

Leukemia, the cancer of blood cells, originates in the blood-forming cells of the bone marrow. In Chronic Myeloid Leukemia (CML) conditions, the cells partially become mature that look like normal white blood cells but do not resist…

Genomics · Quantitative Biology 2023-02-09 Madiha Hameed , Muhammad Bilal , Tuba Majid , Abdul Majid , Asifullah Khan

An often overlooked problem in medical image segmentation research is the effective selection of training subsets to annotate from a complete set of unlabelled data. Many studies select their training sets at random, which may lead to…

Computer Vision and Pattern Recognition · Computer Science 2025-03-24 Stephen Lloyd-Brown , Susan Francis , Caroline Hoad , Penny Gowland , Karen Mullinger , Andrew French , Xin Chen

Class imbalance remains a practical obstacle in the development of clinical prediction models for conditions such as diabetes mellitus, where the number of confirmed cases is often much smaller than the number of controls. The Synthetic…

Machine Learning · Computer Science 2026-05-26 Agnideep Aich , Md Monzur Murshed , Bruce Wade , Sameera Hewage

Reliable classification and detection of certain medical conditions, in images, with state-of-the-art semantic segmentation networks, require vast amounts of pixel-wise annotation. However, the public availability of such datasets is…

Computer Vision and Pattern Recognition · Computer Science 2023-03-17 Erik Ostrowski , Bharath Srinivas Prabakaran , Muhammad Shafique

Weakly supervised semantic segmentation (WSSS) in histopathology reduces pixel-level labeling by learning from image-level labels, but it is hindered by inter-class homogeneity, intra-class heterogeneity, and CAM-induced region shrinkage…

Computer Vision and Pattern Recognition · Computer Science 2025-12-08 Khang Le , Anh Mai Vu , Thi Kim Trang Vo , Ha Thach , Ngoc Bui Lam Quang , Thanh-Huy Nguyen , Minh H. N. Le , Zhu Han , Chandra Mohan , Hien Van Nguyen

Classification algorithms are unable to make reliable models on the datasets with huge sizes. These datasets contain many irrelevant and redundant features that mislead the classifiers. Furthermore, many huge datasets have imbalanced class…

Machine Learning · Computer Science 2014-03-11 Mehdi Naseriparsa , Mohammad Mansour Riahi Kashani

Accurate segmentation and classification of white blood cells (WBCs) in microscopic images are essential for diagnosis and monitoring of many hematological disorders, yet remain challenging due to staining variability, complex backgrounds,…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Mehdi Zekriyapanah Gashti , Mostafa Mohammadpour , Ghasem Farjamnia

The process of identifying and characterizing B-cell epitopes, which are the portions of antigens recognized by antibodies, is important for our understanding of the immune system, and for many applications including vaccine development,…

Quantitative Methods · Quantitative Biology 2025-12-10 Xiao Yuan