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There are two well-known parabolic split $G_2$-geometries in dimension five, $(2,3,5)$-distributions and $G_2$-contact structures. Here we link these two geometries with yet another $G_2$-related contact structure, which lives on a…

Differential Geometry · Mathematics 2022-04-14 Thomas Leistner , Pawel Nurowski , Katja Sagerschnig

Cell migration in fibreous extracellular matrix (ECM) is crucial to many physiological and pathological processes such as tissue regeneration, immune response and cancer progression. During migration, individual cells can generate active…

Cell Behavior · Quantitative Biology 2019-10-16 Yu Zheng , Hanqing Nan , Qihui Fan , Xiaochen Wang , Liyu Liu , Ruchuan Liu , Fangfu Ye , Bo Sun , Yang Jiao

In this paper, we study an extension of the CPE conjecture to manifolds $M$ which support a structure relating curvature to the geometry of a smooth map $\varphi : M \to N$. The resulting system, denoted by $(\varphi-\mathrm{CPE})$, is…

Differential Geometry · Mathematics 2024-01-17 Giulio Colombo , Luciano Mari , Marco Rigoli

The migratory dynamics of cells can be influenced by the complex micro-environment through which they move. It remains unclear how the motility machinery of confined cells responds and adapts to their micro-environment. Here, we propose a…

Biological Physics · Physics 2023-12-04 Johannes Flommersfeld , Stefan Stöberl , Omar Shah , Joachim O. Rädler , Chase P. Broedersz

In this work we introduce a differential rendering module which allows neural networks to efficiently process cluttered data. The module is composed of continuous piecewise differentiable functions defined as a sensor array of cells…

Computer Vision and Pattern Recognition · Computer Science 2019-04-11 Yonatan Svirsky , Andrei Sharf

Visual perception results from a systematic transformation of the information flowing through the visual system. In the neuronal hierarchy, the response properties of single neurons are determined by neurons located one level below, and in…

Neurons and Cognition · Quantitative Biology 2015-08-03 Stephen G. Odaibo

Curvature influences generalization, robustness, and how reliably neural networks respond to small input perturbations. Existing sharpness metrics are typically defined in parameter space (e.g., Hessian eigenvalues) and can be expensive,…

Machine Learning · Computer Science 2025-11-04 Jacob Poschl

We apply spectral sequences to derive both an obstruction to the existence of $n$-fold prolongations and a topological classification. Prolongations have been used in the literature in an attempt to prove that every Engel structure on…

Symplectic Geometry · Mathematics 2012-09-06 Mirko Klukas , Bijan Sahamie

Nearly all cell models explicitly or implicitly deal with the biophysical constraints that must be respected for life to persist. Despite this, there is almost no systematicity in how these constraints are implemented, and we lack a…

Cell Behavior · Quantitative Biology 2026-05-20 Connor McShaffrey , Eran Agmon , Randall D. Beer

In this paper we study some problems related to a vertical Liouville distribution (called vertical Liouville-Hamilton distribution) on the cotangent bundle of a Cartan space. We study the existence of some linear connections of…

Differential Geometry · Mathematics 2014-01-23 Cristian Ida , Adelina Manea

Identifying cerebral cortex layers is crucial for comparative studies of the cytoarchitecture aiming at providing insights into the relations between brain structure and function across species. The absence of extensive annotated datasets…

Computer Vision and Pattern Recognition · Computer Science 2023-11-28 Valentina Vadori , Antonella Peruffo , Jean-Marie Graïc , Giulia Vadori , Livio Finos , Enrico Grisan

The human brain forms functional networks on all spatial scales. Modern fMRI scanners allow to resolve functional brain data in high resolutions, allowing to study large-scale networks that relate to cognitive processes. The analysis of…

Neurons and Cognition · Quantitative Biology 2019-05-14 Melanie Weber , Johannes Stelzer , Emil Saucan , Alexander Naitsat , Gabriele Lohmann , Jürgen Jost

A mathematical model of figure-ground articulation is presented, taking into account both local and global gestalt laws. The model is compatible with the functional architecture of the primary visual cortex (V1). Particularly the local…

Computer Vision and Pattern Recognition · Computer Science 2016-08-30 Marta Favali , Giovanna Citti , Alessandro Sarti

Collective cell migration is crucial in many biological processes such as wound healing, tissue morphogenesis, and tumor progression. The leading front of a collective migrating epithelial cell layer often destabilizes into multicellular…

Biological Physics · Physics 2020-05-07 Yanjun Yang , Herbert Levine

Cells in tissues can organize into a broad spectrum of structures according to their function. Drastic changes of organization, such as epithelial-mesenchymal transitions or the formation of spheroidal aggregates, are often associated…

Biological Physics · Physics 2016-12-22 Bart Smeets , Ricard Alert , Jiri Pesek , Ignacio Pagonabarraga , Herman Ramon , Romaric Vincent

A refined notion of curvature for a linear system of Hermitian vector spaces, in the sense of Grothendieck, leads to the unitary classification of a large class of analytic Hilbert modules. Specifically, we study Hilbert sub-modules, for…

Spectral Theory · Mathematics 2009-09-11 Shibananda Biswas , Gadadhar Misra , Mihai Putinar

Microtubules are filamentous tubular protein polymers which are essential for a range of cellular behaviour, and are generally straight over micron length scales. However, in some gliding assays, where microtubules move over a carpet of…

Subcellular Processes · Quantitative Biology 2018-08-02 Simon P Pearce , Matthias Heil , Oliver E Jensen , Gareth W Jones , Andreas Prokop

Many animal cells change their shape depending on the stiffness of the substrate on which they are cultured: they assume small, rounded shapes in soft ECMs, they elongate within stiffer ECMs, and flatten out on hard substrates. Cells tend…

Cell Behavior · Quantitative Biology 2019-06-24 Elisabeth G. Rens , Roeland M. H. Merks

We analyze the "eigenbundle" (localization bundle) of certain Hilbert modules over bounded symmetric domains of rank $r,$ giving rise to complex-analytic fibre spaces which are stratified of length $r+1.$ The fibres are described in terms…

Functional Analysis · Mathematics 2022-05-26 Harald Upmeier

The cerebellum and cerebral cortex form tightly coupled circuits thought to support flexible and efficient temporal processing. How this interaction shapes cortical learning dynamics, and whether such heterogeneous modularity can benefit…

Neurons and Cognition · Quantitative Biology 2026-05-12 Alexandra Voce , Emmanouil Giannakakis , Claudia Clopath