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Our work is concerned with the generation and targeted design of RNA, a type of genetic macromolecule that can adopt complex structures which influence their cellular activities and functions. The design of large scale and complex…

Biomolecules · Quantitative Biology 2021-02-02 Zichao Yan , William L. Hamilton , Mathieu Blanchette

Tiered latent representations and latent spaces for molecular graphs provide a simple but effective way to explicitly represent and utilize groups (e.g., functional groups), which consist of the atom (node) tier, the group tier and the…

Machine Learning · Computer Science 2019-08-26 Daniel T. Chang

Spatial-temporal graph modeling is an important task to analyze the spatial relations and temporal trends of components in a system. Existing approaches mostly capture the spatial dependency on a fixed graph structure, assuming that the…

Machine Learning · Computer Science 2019-06-04 Zonghan Wu , Shirui Pan , Guodong Long , Jing Jiang , Chengqi Zhang

Skeletonization extracts thin representations from images that compactly encode their geometry and topology. These representations have become an important topological prior for preserving connectivity in curvilinear structures, aiding…

Image and Video Processing · Electrical Eng. & Systems 2025-03-11 Luis D. Reyes Vargas , Martin J. Menten , Johannes C. Paetzold , Nassir Navab , Mohammad Farid Azampour

Purpose: Interpreting chest radiographs (CXR) remains challenging due to the ambiguity of overlapping structures such as the lungs, heart, and bones. To address this issue, we propose a novel method for extracting fine-grained anatomical…

Image and Video Processing · Electrical Eng. & Systems 2023-06-08 Constantin Seibold , Alexander Jaus , Matthias A. Fink , Moon Kim , Simon Reiß , Ken Herrmann , Jens Kleesiek , Rainer Stiefelhagen

Machine learning on graphs is an important and ubiquitous task with applications ranging from drug design to friendship recommendation in social networks. The primary challenge in this domain is finding a way to represent, or encode, graph…

Social and Information Networks · Computer Science 2018-04-11 William L. Hamilton , Rex Ying , Jure Leskovec

Surgical Scene Graphs abstract the complexity of surgical operating rooms (OR) into a structure of entities and their relations, but existing paradigms suffer from strictly dyadic structural limitations. Frameworks that predominantly rely…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Tony Danjun Wang , Ka Young Kim , Tolga Birdal , Nassir Navab , Lennart Bastian

Our ability to produce human-scale bio-manufactured organs is critically limited by the need for vascularization and perfusion. For tissues of variable size and shape, including arbitrarily complex geometries, designing and printing…

Many data-rich industries are interested in the efficient discovery and modelling of structures underlying large data sets, as it allows for the fast triage and dimension reduction of large volumes of data embedded in high dimensional…

Algebraic Topology · Mathematics 2019-09-30 Yossi Bokor , Daniel Grixti-Cheng , Markus Hegland , Stephen Roberts , Katharine Turner

Applying network science approaches to investigate the functions and anatomy of the human brain is prevalent in modern medical imaging analysis. Due to the complex network topology, for an individual brain, mining a discriminative network…

Computer Vision and Pattern Recognition · Computer Science 2020-07-21 Wen Zhang , Liang Zhan , Paul Thompson , Yalin Wang

Deep learning methods for graphs achieve remarkable performance on many node-level and graph-level prediction tasks. However, despite the proliferation of the methods and their success, prevailing Graph Neural Networks (GNNs) neglect…

Machine Learning · Computer Science 2020-11-10 Emily Alsentzer , Samuel G. Finlayson , Michelle M. Li , Marinka Zitnik

Landmarks are central to how people navigate, but most navigation technologies do not incorporate them into their representations. We propose the landmark graph generation task (creating landmark-based spatial representations from natural…

Artificial Intelligence · Computer Science 2020-02-07 Christopher M Cervantes

Vector graphics are essential in design, providing artists with a versatile medium for creating resolution-independent and highly editable visual content. Recent advancements in vision-language and diffusion models have fueled interest in…

Computer Vision and Pattern Recognition · Computer Science 2025-01-08 Sagi Polaczek , Yuval Alaluf , Elad Richardson , Yael Vinker , Daniel Cohen-Or

The development of foundation models for functional magnetic resonance imaging (fMRI) time series holds significant promise for predicting phenotypes related to disease and cognition. Current models, however, are often trained using a…

Machine Learning · Computer Science 2026-03-03 Sam Gijsen , Marc-Andre Schulz , Kerstin Ritter

This work is concerned with a representation of shapes that disentangles fine, local and possibly repeating geometry, from global, coarse structures. Achieving such disentanglement leads to two unrelated advantages: i) a significant…

Computer Vision and Pattern Recognition · Computer Science 2022-04-06 Luca Morreale , Noam Aigerman , Paul Guerrero , Vladimir G. Kim , Niloy J. Mitra

Graph embeddings play a critical role in graph representation learning, allowing machine learning models to explore and interpret graph-structured data. However, existing methods often rely on opaque, high-dimensional embeddings, limiting…

Machine Learning · Computer Science 2025-11-26 Astrit Tola , Funmilola Mary Taiwo , Cuneyt Gurcan Akcora , Baris Coskunuzer

We present SceneTok, a novel tokenizer for encoding view sets of scenes into a compressed and diffusable set of unstructured tokens. Existing approaches for 3D scene representation and generation commonly use 3D data structures or…

Computer Vision and Pattern Recognition · Computer Science 2026-03-02 Mohammad Asim , Christopher Wewer , Jan Eric Lenssen

A computational anatomy atlas is a set of internal organ geometries. It is based on data of real patients and complemented with virtual cases by using a some numerical approach. Atlases are in demand in computational physiology, especially…

Tissues and Organs · Quantitative Biology 2023-03-21 Konstantin Ushenin , Maksim Dzhigil , Vladislav Dordiuk

Biological and cellular systems are often modeled as graphs in which vertices represent objects of interest (genes, proteins, drugs) and edges represent relational ties among these objects (binds-to, interacts-with, regulates). This…

Machine Learning · Statistics 2017-03-16 Jose Lugo-Martinez , Predrag Radivojac

Graph representation learning aims to effectively encode high-dimensional sparse graph-structured data into low-dimensional dense vectors, which is a fundamental task that has been widely studied in a range of fields, including machine…