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Accurately grounding regions of interest (ROIs) is critical for diagnosis and treatment planning in medical imaging. While multimodal large language models (MLLMs) combine visual perception with natural language, current medical-grounding…

Computer Vision and Pattern Recognition · Computer Science 2026-02-19 Zhonghao Yan , Muxi Diao , Yuxuan Yang , Ruoyan Jing , Jiayuan Xu , Kaizhou Zhang , Lele Yang , Yanxi Liu , Kongming Liang , Zhanyu Ma

Medical image segmentation is undergoing a paradigm shift from conventional visual pattern matching to cognitive reasoning analysis. Although Multimodal Large Language Models (MLLMs) have shown promise in integrating linguistic and visual…

Computer Vision and Pattern Recognition · Computer Science 2026-03-09 Yuxin Xie , Yuming Chen , Yishan Yang , Yi Zhou , Tao Zhou , Zhen Zhao , Jiacheng Liu , Huazhu Fu

The rapid advancement of generative AI in medical imaging has introduced both significant opportunities and serious challenges, especially the risk that fake medical images could undermine healthcare systems. These synthetic images pose…

Computer Vision and Pattern Recognition · Computer Science 2025-09-22 Shuaibo Li , Zhaohu Xing , Hongqiu Wang , Pengfei Hao , Xingyu Li , Zekai Liu , Lei Zhu

The increasing realism of AI-generated images has raised serious concerns about misinformation and privacy violations, highlighting the urgent need for accurate and interpretable detection methods. While existing approaches have made…

Computer Vision and Pattern Recognition · Computer Science 2025-09-25 Tai-Ming Huang , Wei-Tung Lin , Kai-Lung Hua , Wen-Huang Cheng , Junichi Yamagishi , Jun-Cheng Chen

Deepfake detection is a widely researched topic that is crucial for combating the spread of malicious content, with existing methods mainly modeling the problem as classification or spatial localization. The rapid advancements in generative…

Computer Vision and Pattern Recognition · Computer Science 2026-02-02 Wenbo Xu , Wei Lu , Xiangyang Luo , Jiantao Zhou

Deepfake detection models often generate natural-language explanations, yet their reasoning is frequently ungrounded in visual evidence, limiting reliability. Existing evaluations measure classification accuracy but overlook reasoning…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Kartik Kuckreja , Parul Gupta , Muhammad Haris Khan , Abhinav Dhall

As we all know, hallucinations prevail in Large Language Models (LLMs), where the generated content is coherent but factually incorrect, which inflicts a heavy blow on the widespread application of LLMs. Previous studies have shown that…

Computation and Language · Computer Science 2024-10-15 Xinping Zhao , Jindi Yu , Zhenyu Liu , Jifang Wang , Dongfang Li , Yibin Chen , Baotian Hu , Min Zhang

Misdiagnosis causes significant harm to healthcare systems worldwide, leading to increased costs and patient risks. MedRAG is a smart multimodal healthcare copilot equipped with powerful large language model (LLM) reasoning, designed to…

Artificial Intelligence · Computer Science 2025-06-04 Xuejiao Zhao , Siyan Liu , Su-Yin Yang , Chunyan Miao

In modern medicine, clinical diagnosis relies on the comprehensive analysis of primarily textual and visual data, drawing on medical expertise to ensure systematic and rigorous reasoning. Recent advances in large Vision-Language Models…

Artificial Intelligence · Computer Science 2025-07-03 Ziyue Wang , Junde Wu , Linghan Cai , Chang Han Low , Xihong Yang , Qiaxuan Li , Yueming Jin

The potential of Multimodal Large Language Models (MLLMs) in domain of medical imaging raise the demands of systematic and rigorous evaluation frameworks that are aligned with the real-world medical imaging practice. Existing practices that…

Computation and Language · Computer Science 2026-04-16 Zhijie Bao , Fangke Chen , Licheng Bao , Chenhui Zhang , Wei Chen , Jiajie Peng , Zhongyu Wei

With the rapid growth of large language models (LLMs) and vision-language models (VLMs) in medicine, simply integrating clinical text and medical imaging does not guarantee reliable reasoning. Existing multimodal models often produce…

Artificial Intelligence · Computer Science 2025-12-29 Zelin Zang , Wenyi Gu , Siqi Ma , Dan Yang , Yue Shen , Zhu Zhang , Guohui Fan , Wing-Kuen Ling , Fuji Yang

Progress in image generation raises significant public security concerns. We argue that fake image detection should not operate as a "black box". Instead, an ideal approach must ensure both strong generalization and transparency. Recent…

Computer Vision and Pattern Recognition · Computer Science 2025-11-10 Yikun Ji , Yan Hong , Jiahui Zhan , Haoxing Chen , jun lan , Huijia Zhu , Weiqiang Wang , Liqing Zhang , Jianfu Zhang

Medical image segmentation is crucial for clinical diagnosis, yet existing models are limited by their reliance on explicit human instructions and lack the active reasoning capabilities to understand complex clinical questions. While recent…

Computer Vision and Pattern Recognition · Computer Science 2025-06-13 Yu Huang , Zelin Peng , Yichen Zhao , Piao Yang , Xiaokang Yang , Wei Shen

Large language models with reasoning capabilities have demonstrated impressive performance across a wide range of domains. In clinical applications, a transparent, step-by-step reasoning process provides physicians with strong evidence to…

Artificial Intelligence · Computer Science 2025-12-16 Linjie Mu , Yannian Gu , Zhongzhen Huang , Yakun Zhu , Shaoting Zhang , Xiaofan Zhang

The clinical adoption of artificial intelligence (AI) in medical diagnostics is critically hampered by its black-box nature, which prevents clinicians from verifying the rationale behind automated decisions. To overcome this fundamental…

Recent progress in multimodal large language models (MLLMs) has demonstrated promising performance on medical benchmarks and in preliminary trials as clinical assistants. Yet, our pilot audit of diagnostic cases uncovers a critical failure…

Artificial Intelligence · Computer Science 2025-09-30 Hongjun Liu , Yinghao Zhu , Yuhui Wang , Yitao Long , Zeyu Lai , Lequan Yu , Chen Zhao

The rapid advancement of image generation technologies intensifies the demand for interpretable and robust detection methods. Although existing approaches often attain high accuracy, they typically operate as black boxes without providing…

Computer Vision and Pattern Recognition · Computer Science 2025-06-10 Yikun Ji , Hong Yan , Jun Lan , Huijia Zhu , Weiqiang Wang , Qi Fan , Liqing Zhang , Jianfu Zhang

Large vision-language models (VLMs) demonstrate strong performance in medical image understanding, but frequently generate clinically plausible yet incorrect statements, raising significant safety concerns. Existing medical hallucination…

Large Vision Language Models (LVLMs) are becoming increasingly important in the medical domain, yet Medical LVLMs (Med-LVLMs) frequently generate hallucinations due to limited expertise and the complexity of medical applications. Existing…

Computer Vision and Pattern Recognition · Computer Science 2025-03-05 Aofei Chang , Le Huang , Parminder Bhatia , Taha Kass-Hout , Fenglong Ma , Cao Xiao

Diagnosing hepatic diseases accurately and interpretably is critical, yet it remains challenging in real-world clinical settings. Existing AI approaches for clinical diagnosis often lack transparency, structured reasoning, and…

Artificial Intelligence · Computer Science 2026-03-06 Zheng Li , Jiayi Xu , Zhikai Hu , Hechang Chen , Lele Cong , Yunyun Wang , Shuchao Pang
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