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Medication recommender is to suggest appropriate medication combinations based on a patient's health history, e.g., diagnoses and procedures. Existing works represent different diagnoses/procedures well separated by one-hot encodings.…

Information Retrieval · Computer Science 2024-11-06 Yuliang Liang , Yuting Liu , Yizhou Dang , Enneng Yang , Guibing Guo , Wei Cai , Jianzhe Zhao , Xingwei Wang

Medication recommendation is a crucial task for intelligent healthcare systems. Previous studies mainly recommend medications with electronic health records (EHRs). However, some details of interactions between doctors and patients may be…

Computation and Language · Computer Science 2022-09-16 Zhenfeng He , Yuqiang Han , Zhenqiu Ouyang , Wei Gao , Hongxu Chen , Guandong Xu , Jian Wu

For modern recommender systems, the use of low-dimensional latent representations to embed users and items based on their observed interactions has become commonplace. However, many existing recommendation models are primarily designed for…

Information Retrieval · Computer Science 2024-12-30 Lianghao Xia , Meiyan Xie , Yong Xu , Chao Huang

Knowledge Graphs have been one of the fundamental methods for integrating heterogeneous data sources. Integrating heterogeneous data sources is crucial, especially in the biomedical domain, where central data-driven tasks such as drug…

Machine Learning · Computer Science 2020-12-22 Islam Akef Ebeid , Majdi Hassan , Tingyi Wanyan , Jack Roper , Abhik Seal , Ying Ding

Drug combination therapy is a well-established strategy for disease treatment with better effectiveness and less safety degradation. However, identifying novel drug combinations through wet-lab experiments is resource intensive due to the…

Machine Learning · Computer Science 2023-01-18 Zhihang Hu , Qinze Yu , Yucheng Guo , Taifeng Wang , Irwin King , Xin Gao , Le Song , Yu Li

A pharmacological effect of a drug on cells, organs and systems refers to the specific biochemical interaction produced by a drug substance, which is called its mechanism of action. Drug repositioning (or drug repurposing) is a fundamental…

Machine Learning · Computer Science 2020-05-19 Dehua Chen , Amir Jalilifard , Adriano Veloso , Nivio Ziviani

Adverse drug reactions (ADRs) are a major barrier to safe and effective pharmacotherapy and increasingly reflect higher order interactions between drugs, genetic background, and clinical phenotypes. Existing graph based approaches usually…

Quantitative Methods · Quantitative Biology 2025-12-02 Ze Cai , Haotian Tang , Shuai Gao , Binbin Zhou , Junhan Zhao , Jun Wen

Recent advancements in medical entity linking have been applied in the area of scientific literature and social media data. However, with the adoption of telemedicine and conversational agents such as Alexa in healthcare settings, medical…

Computation and Language · Computer Science 2020-10-13 Shaoqing Yuan , Parminder Bhatia , Busra Celikkaya , Haiyang Liu , Kyunghwan Choi

Medical report generation is crucial for clinical diagnosis and patient management, summarizing diagnoses and recommendations based on medical imaging. However, existing work often overlook the clinical pipeline involved in report writing,…

Computer Vision and Pattern Recognition · Computer Science 2024-12-24 Xiaofei Huang , Wenting Chen , Jie Liu , Qisheng Lu , Xiaoling Luo , Linlin Shen

Evidence-based medicine (EBM) plays a crucial role in the application of large language models (LLMs) in healthcare, as it provides reliable support for medical decision-making processes. Although it benefits from current…

Computation and Language · Computer Science 2025-03-24 Chengfeng Dou , Ying Zhang , Zhi Jin , Wenpin Jiao , Haiyan Zhao , Yongqiang Zhao , Zhengwei Tao

Health monitoring systems have revolutionized modern healthcare by enabling the continuous capture of physiological and behavioral data, essential for preventive measures and early health intervention. While integrating this data with Large…

Machine Learning · Computer Science 2024-06-26 Ajan Subramanian , Zhongqi Yang , Iman Azimi , Amir M. Rahmani

Medication recommendation aims to integrate patients' long-term health records to provide accurate and safe medication combinations for specific health states. Existing methods often fail to deeply explore the true causal relationships…

Information Retrieval · Computer Science 2024-10-31 Shunpan Liang , Xiang Li , Shi Mu , Chen Li , Yu Lei , Yulei Hou , Tengfei Ma

Deep learning models exhibit state-of-the-art performance for many predictive healthcare tasks using electronic health records (EHR) data, but these models typically require training data volume that exceeds the capacity of most healthcare…

Machine Learning · Computer Science 2018-10-24 Edward Choi , Cao Xiao , Walter F. Stewart , Jimeng Sun

Large language models (LLMs) have revolutionized natural language processing, yet their practical utility is often limited by persistent issues of hallucinations and outdated parametric knowledge. Although post-training model editing offers…

Computation and Language · Computer Science 2026-02-03 Yash Kumar Atri , Ahmed Alaa , Thomas Hartvigsen

Accurate characterization of hippocampal substructure is crucial for detecting subtle structural changes and identifying early neurodegenerative biomarkers. However, high inter-subject variability and complex folding pattern of human…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Na Gao , Chenfei Ye , Yanwu Yang , Anqi Li , Zhengbo He , Li Liang , Zhiyuan Liu , Xingyu Hao , Ting Ma , Tengfei Guo

Background: Medication review is a structured interview of the patient, performed by the pharmacist and aimed at optimizing drug treatments. In practice, medication review is a long and cognitively-demanding task that requires specific…

The vast amount of biomedical information available today presents a significant challenge for investigators seeking to digest, process, and understand these findings effectively. Large Language Models (LLMs) have emerged as powerful tools…

Computation and Language · Computer Science 2024-07-19 Alexander R. Pelletier , Joseph Ramirez , Irsyad Adam , Simha Sankar , Yu Yan , Ding Wang , Dylan Steinecke , Wei Wang , Peipei Ping

Recent advancements in recommender systems have focused on integrating knowledge graphs (KGs) to leverage their auxiliary information. The core idea of KG-enhanced recommenders is to incorporate rich semantic information for more accurate…

Information Retrieval · Computer Science 2024-07-08 Darnbi Sakong , Viet Hung Vu , Thanh Trung Huynh , Phi Le Nguyen , Hongzhi Yin , Quoc Viet Hung Nguyen , Thanh Tam Nguyen

Medication recommendation systems have gained significant attention in healthcare as a means of providing tailored and effective drug combinations based on patients' clinical information. However, existing approaches often suffer from…

Machine Learning · Computer Science 2024-08-13 Zihao Zhao , Yi Jing , Fuli Feng , Jiancan Wu , Chongming Gao , Xiangnan He

Session-based recommender systems aim to improve recommendations in short-term sessions that can be found across many platforms. A critical challenge is to accurately model user intent with only limited evidence in these short sessions. For…

Information Retrieval · Computer Science 2021-12-30 Jianling Wang , Kaize Ding , Ziwei Zhu , James Caverlee