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Label-free microscopy exploits light scattering to obtain a three-dimensional image of biological tissues. However, light propagation is affected by aberrations and multiple scattering, which drastically degrade the image quality and limit…

This paper is concerned with parameter identification problem for finite impulse response (FIR) systems with binary-valued observations under low computational complexity. Most of the existing algorithms under binary-valued observations…

Systems and Control · Electrical Eng. & Systems 2024-12-09 Tianning Han , Ying Wang , Yanlong Zhao

Interstellar ices are largely composed of frozen water. It is important to derive fundamental parameters for H$_2$O ice such as absorption and scattering opacities for which accurate complex refractive indexes are needed. The primary goal…

Instrumentation and Methods for Astrophysics · Physics 2023-12-20 W. R. M. Rocha , M. G. Rachid , M. K. McClure , J. He , H. Linnartz

All-reflective interferometry based on nano-structured diffraction gratings offers new possibilities for gravitational wave detection. We investigate an all-reflective Fabry-Perot interferometer concept in 2nd order Littrow mount. The…

In this paper we report on the measurement and modelling of enhanced optical refractometric sensors based on whispering-gallery-modes. The devices under test are optical microresonators made of silicon nitride on silicon oxide. In our…

Materials with a zero refractive index support electromagnetic modes that exhibit stationary phase profiles. While such materials have been realized across the visible and near-infrared spectral range, radiative and dissipative optical…

Interferometric scattering microscopy has been a very promising technology for highly sensitive label-free imaging of a broad spectrum of biological nanoparticles from proteins to viruses in a high-throughput manner. Although it can reveal…

Optics · Physics 2021-08-11 Celalettin Yurdakul , Haonan Zong , Yeran Bai , Ji-Xin Cheng , M. Selim Unlu

This work introduces a novel reinterpretation of structured illumination (SI) microscopy for coherent imaging that allows three-dimensional imaging of complex refractive index (RI). To do so, we show that coherent SI is mathematically…

Optics · Physics 2017-05-11 Shwetadwip Chowdhury , Will J. Eldridge , Adam Wax , Joseph A. Izatt

We report the modification of a label-free image scanning microscope (ISM) to perform asynchronous 2D imaging at 24kHz while keeping the lateral resolution gain and background rejection of a regular label-free ISM setup. Our method uses a…

Optics · Physics 2023-08-31 Duc-Minh Ta , Alberto Aguilar , Pierre Bon

Conventional bright-field (BF) cytology of thyroid fine-needle aspiration biopsy (FNAB) suffers from staining variability and limited subcellular contrast. Here, we present a refractive index-correlated pseudocoloring (RICP) framework that…

We describe the recent modifications to the data reduction technique for observations acquired with the scanning Fabry-Perot interferometer (FPI) mounted on the 6-m telescope of the Special Astrophysical Observatory that allow the…

Instrumentation and Methods for Astrophysics · Physics 2015-12-09 A. V. Moiseev

The CarbON [CII] line in post-rEionisation and ReionisaTiOn epoch (CONCERTO) instrument is a low-resolution mapping Fourier-transform spectrometer, based on lumped-element kinetic inductance detector (LEKID) technology, operating at 130-…

Interaction-free measurement (IFM) is a promising technique for low-dose detection and imaging, offering the unique advantage of probing an object without absorption of the interrogating photons. We propose an experiment to demonstrate IFM…

Quantum Physics · Physics 2024-07-10 Ron Cohen , Sharon Shwartz , Eliahu Cohen

A modified weak measurement scheme, rotatory biased weak measurement, is proposed to significantly improve the sensitivity and resolution of the refractive index sensor on a total reflection structure. This method introduces an additional…

Quantum Physics · Physics 2022-04-25 Chongqi Zhou , Yang Xu , Xiaonan Zhang , Zhangyan Li , Tian Guan , Yonghong He , Yanhong Ji

We present an innovative optical imaging system for measuring parameters of a small particle such as a macromolecule or nanoparticle at the quantum limit of sensitivity. In comparison to the conventional confocal interferometric scattering…

Quantum Physics · Physics 2025-07-14 Fabian Müller , Emre Köse , Alfred J. Meixner , Erik Schäffer , Daniel Braun

Most integrated evanescent-field photonic sensors measure changes in either the real part or the imaginary part of the complex refractive index of the sample, i.e., refraction or absorption. Here we propose and experimentally demonstrate a…

Vibrational microscopy provides label-free, bond-selective chemical contrast by detecting molecular vibrations, making it invaluable for biomedical research. While conventional methods rely on the direct detection of Raman scattering or…

Optics · Physics 2025-02-10 Keiichiro Toda , Takuro Ideguchi

Optical complex materials offer unprecedented opportunity to engineer fundamental band dispersion which enables novel optoelectronic functionality and devices. Exploration of photonic Dirac cone at the center of momentum space has inspired…

Single-molecule detection enables direct observation of individual biomolecular events, providing mechanistic insights into biological processes and offering a powerful tool for disease diagnostics. However, the fundamental scale mismatch…

Optics · Physics 2025-10-14 Guifeng Li , Chaoyang Gong

Quantum computers require both scalability and high performance for practical applications. While semiconductor quantum dots are promising candidates for quantum bits, the complexity of measurement setups poses an important challenge for…

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