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The quantum approximate optimization algorithm (QAOA) is a hybrid variational quantum-classical algorithm that solves combinatorial optimization problems. While there is evidence suggesting that the fixed form of the standard QAOA ansatz is…

Quantum annealing (QA) is a promising approach for solving combinatorial optimization problems; however, it is known to exhibit unfair sampling, in which degenerate ground states are not sampled with equal probability even for sufficiently…

Quantum Physics · Physics 2026-04-14 Shunta Ide , Shu Tanaka

We present a quantum annealing-based solution method for topology optimization (TO). In particular, we consider TO in a more general setting, i.e., applied to structures of continuum domains where designs are represented as distributed…

Numerical Analysis · Mathematics 2023-01-30 Zisheng Ye , Xiaoping Qian , Wenxiao Pan

Quantum computers show potential for achieving computational advantage over classical computers, with many candidate applications in combinatorial optimisation. We present an application level benchmarking framework for near-term quantum…

Over the past decade, the usefulness of quantum annealing hardware for combinatorial optimization has been the subject of much debate. Thus far, experimental benchmarking studies have indicated that quantum annealing hardware does not…

Optimization and Control · Mathematics 2022-10-11 Byron Tasseff , Tameem Albash , Zachary Morrell , Marc Vuffray , Andrey Y. Lokhov , Sidhant Misra , Carleton Coffrin

Digital Annealer (DA) is a computer architecture designed for tackling combinatorial optimization problems formulated as quadratic unconstrained binary optimization (QUBO) models. In this paper, we present the results of an extensive…

Optimization and Control · Mathematics 2020-12-24 Oylum Şeker , Neda Tanoumand , Merve Bodur

Molecular docking (MD) is a crucial task in drug design, which predicts the position, orientation, and conformation of the ligand when bound to a target protein. It can be interpreted as a combinatorial optimization problem, where quantum…

Chemical Physics · Physics 2024-04-15 Yunting Li , Xiaopeng Cui , Zhaoping Xiong , Bowen Liu , Bi-Ying Wang , Runqiu Shu , Nan Qiao , Man-Hong Yung

The standard approach to encoding constraints in quantum optimization is the quadratic penalty method. Quadratic penalties introduce additional couplings and energy scales, which can be detrimental to the performance of a quantum optimizer.…

Quantum Physics · Physics 2024-12-17 Puya Mirkarimi , David C. Hoyle , Ross Williams , Nicholas Chancellor

Constrained binary optimization aims to find an optimal assignment to minimize or maximize the objective meanwhile satisfying the constraints, which is a representative NP problem in various domains, including transportation, scheduling,…

Quantum Physics · Physics 2025-08-18 Debin Xiang , Qifan Jiang , Liqiang Lu , Siwei Tan , Jianwei Yin

Quantum annealing (QA) has gained considerable attention because it can be applied to combinatorial optimization problems, which have numerous applications in logistics, scheduling, and finance. In recent years, research on solving…

Quantum Physics · Physics 2022-05-04 Michiya Kuramata , Ryota Katsuki , Kazuhide Nakata

Quantum optimization has gained increasing attention as advances in quantum hardware enable the exploration of problem instances approaching real-world scale. Among existing approaches, variational quantum algorithms and quantum annealing…

Quantum annealing (QA) is a hardware-based heuristic optimization and sampling method applicable to discrete undirected graphical models. While similar to simulated annealing, QA relies on quantum, rather than thermal, effects to explore…

Recent advances in the development of commercial quantum annealers such as the D-Wave 2X allow solving NP-hard optimization problems that can be expressed as quadratic unconstrained binary programs. However, the relatively small number of…

Quantum Physics · Physics 2018-02-01 Georg Hahn , Hristo N. Djidjev

Quadratic unconstrained binary optimization (QUBO) is a field of operations research that is attracting growing interest due to the recent availability of quantum hardware targeted at solving QUBO problems. However, practical adoption is…

Software Engineering · Computer Science 2026-01-22 Lodovica Marchesi , Amal Nasharti , Michele Marchesi

The Quantum Approximate Optimization Algorithm (QAOA) is an algorithmic framework for finding approximate solutions to combinatorial optimization problems, derived from an approximation to the Quantum Adiabatic Algorithm (QAA). In solving…

Quantum Physics · Physics 2020-02-05 Yue Ruan , Samuel Marsh , Xilin Xue , Xi Li , Zhihao Liu , Jingbo Wang

The quantum approximate optimization algorithm (QAOA) is a hybrid quantum-classical variational algorithm that offers the potential to handle combinatorial optimization problems. Introducing constraints in such combinatorial optimization…

Quantum Physics · Physics 2021-12-15 Santosh Kumar Radha

Variational quantum algorithms have attracted attention for their potential to solve combinatorial optimization problems. We study how the choice of encoding affects the resource requirements and optimization behavior of a variational…

Quantum Physics · Physics 2026-05-12 Linus Ekstrøm , Hao Wang , Sebastian Schmitt

Quantum optimization algorithms offer a promising route to finding the ground states of target Hamiltonians on near-term quantum devices. None the less, it remains necessary to limit the evolution time and circuit depth as much as possible,…

Quantum Physics · Physics 2022-11-01 Chenfeng Cao , Yunlong Yu , Zipeng Wu , Nic Shannon , Bei Zeng , Robert Joynt

We assess the prospects for algorithms within the general framework of quantum annealing (QA) to achieve a quantum speedup relative to classical state of the art methods in combinatorial optimization and related sampling tasks. We argue for…

Quantum Physics · Physics 2021-06-22 E. J. Crosson , D. A. Lidar

The field of Quantum Computing has gathered significant popularity in recent years and a large number of papers have studied its effectiveness in tackling many tasks. We focus in particular on Quantum Annealing (QA), a meta-heuristic solver…

Quantum Physics · Physics 2026-03-03 Riccardo Pellini , Maurizio Ferrari Dacrema
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