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In many human brain network studies, we do not have sufficient number (n) of images relative to the number (p) of voxels due to the prohibitively expensive cost of scanning enough subjects. Thus, brain network models usually suffer the…

Artificial Intelligence · Computer Science 2016-06-30 Moo K. Chung , Victoria Vilalta-Gil , Paul J. Rathouz , Benjamin B. Lahey , David H. Zald

Topological data analysis involves the statistical characterization of the shape of data. Persistent homology is a primary tool of topological data analysis, which can be used to analyze topological features and perform statistical…

Methodology · Statistics 2023-03-01 Chul Moon , Nicole A. Lazar

Complex networks encountered in biology are often characterized by significant structural diversity. Whether it be differences in the three-dimensional structure of allosteric proteins, or the variation among the micro-scale structures of…

Physics and Society · Physics 2020-08-19 Jason W. Rocks , Andrea J. Liu , Eleni Katifori

Persistent homology (PH) is a method for generating topology-inspired representations of data. Empirical studies that investigate the properties of PH, such as its sensitivity to perturbations or ability to detect a feature of interest,…

Algebraic Topology · Mathematics 2024-03-05 Shuang Liang , Renata Turkeš , Jiayi Li , Nina Otter , Guido Montúfar

Persistent Homology (PH) offers stable, multi-scale descriptors of intrinsic shape structure by capturing connected components, loops, and voids that persist across scales, providing invariants that complement purely geometric…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Prachi Kudeshia , Jiju Poovvancheri , Amr Ghoneim , Dong Chen

Spatial transcriptomics (ST) measures gene expression at a set of spatial locations in a tissue. Communities of nearby cells that express similar genes form \textit{spatial domains}. Specialized ST clustering algorithms have been developed…

Quantitative Methods · Quantitative Biology 2025-11-12 Perry Beamer , Zixuan Cang

Representation learning on graphs is a fundamental problem that can be crucial in various tasks. Graph neural networks, the dominant approach for graph representation learning, are limited in their representation power. Therefore, it can be…

Machine Learning · Computer Science 2025-01-17 Zuoyu Yan , Qi Zhao , Ze Ye , Tengfei Ma , Liangcai Gao , Zhi Tang , Yusu Wang , Chao Chen

Functional magnetic resonance imaging (fMRI) has been commonly used to construct functional connectivity networks (FCNs) of the human brain. TFCNs are primarily limited to quantifying pairwise relationships between ROIs ignoring higher…

Signal Processing · Electrical Eng. & Systems 2025-07-15 Duc Vu , Selin Aviyente

Segmenting stroke lesions from T1-weighted MR images is of great value for large-scale stroke rehabilitation neuroimaging analyses. Nevertheless, there are great challenges with this task, such as large range of stroke lesion scales and the…

Image and Video Processing · Electrical Eng. & Systems 2021-02-17 Hao Yang , Weijian Huang , Kehan Qi , Cheng Li , Xinfeng Liu , Meiyun Wang , Hairong Zheng , Shanshan Wang

Topological features based on persistent homology capture high-order structural information so as to augment graph neural network methods. However, computing extended persistent homology summaries remains slow for large and dense graphs and…

Machine Learning · Computer Science 2022-11-16 Zuoyu Yan , Tengfei Ma , Liangcai Gao , Zhi Tang , Yusu Wang , Chao Chen

Persistent homology is a technique recently developed in algebraic and computational topology well-suited to analysing structure in complex, high-dimensional data. In this paper, we exposit the theory of persistent homology from first…

Applications · Statistics 2016-11-30 Matthew Pietrosanu

Recent years have witnessed a fast growth in mathematical artificial intelligence (AI). One of the most successful mathematical AI approaches is topological data analysis (TDA) via persistent homology (PH) that provides explainable AI (xAI)…

General Topology · Mathematics 2025-10-27 Yiming Ren , Guowei Wei

The latent space model is one of the well-known methods for statistical inference of network data. While the model has been much studied for a single network, it has not attracted much attention to analyze collectively when multiple…

Methodology · Statistics 2022-08-29 Kisung You , Ilmun Kim , Ick Hoon Jin , Minjeong Jeon , Dennis Shung

As the field of Topological Data Analysis continues to show success in theory and in applications, there has been increasing interest in using tools from this field with methods for machine learning. Using persistent homology, specifically…

Computational Geometry · Computer Science 2020-02-26 Sarah Tymochko , Elizabeth Munch , Firas A. Khasawneh

A central question for neuroscience is how to characterize brain representations of perceptual and cognitive content. An ideal characterization should distinguish different functional regions with robustness to noise and idiosyncrasies of…

Neurons and Cognition · Quantitative Biology 2024-10-17 Baihan Lin , Nikolaus Kriegeskorte

We explore the recently introduced persistent reachability homology (PRH) of digraph data, i.e. data in the form of directed graphs. In particular, we study the effectiveness of PRH in network classification task in a key neuroscience…

Machine Learning · Computer Science 2025-11-10 Luigi Caputi , Nicholas Meadows , Henri Riihimäki

We study the persistent homology of both functional data on compact topological spaces and structural data presented as compact metric measure spaces. One of our goals is to define persistent homology so as to capture primarily properties…

Algebraic Topology · Mathematics 2018-11-27 Haibin Hang , Facundo Mémoli , Washington Mio

Persistent homology analysis provides means to capture the connectivity structure of data sets in various dimensions. On the mathematical level, by defining a metric between the objects that persistence attaches to data sets, we can…

Machine Learning · Computer Science 2019-06-12 Henri Riihimäki , José Licón-Saláiz

In this paper, we use topological data analysis techniques to construct a suitable neural network classifier for the task of learning sensor signals of entire power plants according to their reference designation system. We use…

Machine Learning · Computer Science 2026-03-24 Luciano Melodia , Richard Lenz

We present a novel method to explicitly incorporate topological prior knowledge into deep learning based segmentation, which is, to our knowledge, the first work to do so. Our method uses the concept of persistent homology, a tool from…

Computer Vision and Pattern Recognition · Computer Science 2019-01-30 James R. Clough , Ilkay Oksuz , Nicholas Byrne , Julia A. Schnabel , Andrew P. King
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