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In this article, we introduce a Topological Data Analysis (TDA) pipeline for neural spike train data. Understanding how the brain transforms sensory information into perception and behavior requires analyzing coordinated neural population…

Methodology · Statistics 2025-12-10 Cagatay Ayhan , Audrey N. Nash , Roberto Vincis , Martin Bauer , Richard Bertram , Tom Needham

The closed loops or cycles in a brain network embeds higher order signal transmission paths, which provide fundamental insights into the functioning of the brain. In this work, we propose an efficient algorithm for systematic identification…

Neurons and Cognition · Quantitative Biology 2023-01-04 D. Vijay Anand , Moo K. Chung

Recent studies have actively employed persistent homology (PH), a topological data analysis technique, to analyze the topological information in time series data. Many successful studies have utilized graph representations of time series…

Algebraic Topology · Mathematics 2025-12-15 Eunwoo Heo , Jae-Hun Jung

Persistent homology computes topological invariants from point cloud data. Recent work has focused on developing statistical methods for data analysis in this framework. We show that, in certain models, parametric inference can be performed…

Quantitative Methods · Quantitative Biology 2014-06-19 Kevin Emmett , Daniel Rosenbloom , Pablo Camara , Raul Rabadan

We introduce a method for training neural networks to perform image or volume segmentation in which prior knowledge about the topology of the segmented object can be explicitly provided and then incorporated into the training process. By…

Computer Vision and Pattern Recognition · Computer Science 2020-09-21 James R. Clough , Nicholas Byrne , Ilkay Oksuz , Veronika A. Zimmer , Julia A. Schnabel , Andrew P. King

Data quality is crucial for the successful training, generalization and performance of machine learning models. We propose to measure the quality of a subset concerning the dataset it represents, using topological data analysis techniques.…

Algebraic Topology · Mathematics 2024-10-01 Álvaro Torras-Casas , Eduardo Paluzo-Hidalgo , Rocio Gonzalez-Diaz

Long lived topological features are distinguished from short lived ones (considered as topological noise) in simplicial complexes constructed from complex networks. A new topological invariant, persistent homology, is determined and…

Mathematical Physics · Physics 2009-11-13 Danijela Horak , Slobodan Maletic , Milan Rajkovic

Inferring topological and geometrical information from data can offer an alternative perspective on machine learning problems. Methods from topological data analysis, e.g., persistent homology, enable us to obtain such information,…

Computer Vision and Pattern Recognition · Computer Science 2018-02-19 Christoph Hofer , Roland Kwitt , Marc Niethammer , Andreas Uhl

Medical image segmentation, which aims to automatically extract anatomical or pathological structures, plays a key role in computer-aided diagnosis and disease analysis. Despite the problem has been widely studied, existing methods are…

Image and Video Processing · Electrical Eng. & Systems 2022-03-01 Han Zhang , Lok Ming Lui

Techniques from computational topology, in particular persistent homology, are becoming increasingly relevant for data analysis. Their stable metrics permit the use of many distance-based data analysis methods, such as multidimensional…

Algebraic Topology · Mathematics 2021-01-20 Bastian Rieck , Filip Sadlo , Heike Leitte

This paper presents a mathematically rigorous framework for brain-inspired representation learning founded on the interplay between persistent topological structures and cohomological flows. Neural computation is reformulated as the…

Machine Learning · Computer Science 2025-12-10 Preksha Girish , Rachana Mysore , Mahanthesha U , Shrey Kumar , Shipra Prashant

Persistent homology (PH) is a crucial concept in computational topology, providing a multiscale topological description of a space. It is particularly significant in topological data analysis, which aims to make statistical inference from a…

Machine Learning · Statistics 2025-11-25 Sing-Yuan Yeh , Chun-Hao Yang

Functional brain connectivity changes dynamically over time, making its representation challenging for learning on non-Euclidean data. We present a framework that encodes dynamic functional connectivity as an image representation of…

Neurons and Cognition · Quantitative Biology 2025-11-14 Peilin He , Tananun Songdechakraiwut

We propose the Topology-Preserving Segmentation Network, a deformation-based model that can extract objects in an image while maintaining their topological properties. This network generates segmentation masks that have the same topology as…

Computer Vision and Pattern Recognition · Computer Science 2024-06-18 Han Zhang , Lok Ming Lui

We introduce an innovative, data-driven topological data analysis (TDA) technique for estimating the state spaces of dynamically changing functional human brain networks at rest. Our method utilizes the Wasserstein distance to measure…

Algebraic Topology · Mathematics 2024-04-18 Moo K. Chung , Shih-Gu Huang , Ian C. Carroll , Vince D. Calhoun , H. Hill Goldsmith

Objective: Post-traumatic epilepsy (PTE) is a debilitating neurological disorder that develops after traumatic brain injury (TBI). Early prediction of PTE remains challenging due to heterogeneous clinical data, limited positive cases, and…

Machine Learning · Computer Science 2026-04-17 Wenhui Cui , Nicholas Swingle , Anand A. Joshi , Dileep Nair , Richard M. Leahy

Accurate and interpretable brain tumor classification from medical imaging remains a challenging problem due to the high dimensionality and complex structural patterns present in magnetic resonance imaging (MRI). In this study, we propose a…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Faisal Ahmed

Persistent topological properties of an image serve as an additional descriptor providing an insight that might not be discovered by traditional neural networks. The existing research in this area focuses primarily on efficiently…

Computer Vision and Pattern Recognition · Computer Science 2023-03-07 Ekaterina Khramtsova , Guido Zuccon , Xi Wang , Mahsa Baktashmotlagh

Persistent homology, a technique from computational topology, has recently shown strong empirical performance in the context of graph classification. Being able to capture long range graph properties via higher-order topological features,…

Machine Learning · Computer Science 2024-12-20 Rubén Ballester , Bastian Rieck

Applying network science approaches to investigate the functions and anatomy of the human brain is prevalent in modern medical imaging analysis. Due to the complex network topology, for an individual brain, mining a discriminative network…

Computer Vision and Pattern Recognition · Computer Science 2020-07-21 Wen Zhang , Liang Zhan , Paul Thompson , Yalin Wang