Related papers: The FLASH enigma
Radiotherapy with Very High Energy Electron (VHEE) beams is being extensively investigated for the treatment of deep-seated tumours, even in view of novel protocols based on the so-called FLASH effect. Laser WakeField Acceleration (LWFA)…
It is proposed to treat cancer by the combination of a strong magnetic field with intense ultrasound. At the low electrical conductivity of tissue the magnetic field is not frozen into the tissue, and oscillates against the tissue which is…
We analyze the effect of tumor repopulation on optimal dose delivery in radiation therapy. We are primarily motivated by accelerated tumor repopulation towards the end of radiation treatment, which is believed to play a role in treatment…
The FLASH effect refers to a lower normal tissue damage for an equivalent tumour response, potentially widening the therapeutic window for radiotherapy. Although this effect has been demonstrated in various experiments using different types…
We model the interaction between the immune system and tumor cells including a time delay to simulate the time needed by the latter to develop a chemical and cell mediated response to the presence of the tumor. The results are compared with…
Objective: Radiolytic oxygen depletion (ROD) may play a role in the sparing of cells irradiated with ultra-high dose rates. Different methods have been used to quantify the effect of ROD during FLASH irradiation on cell survival, typically…
In this paper, a reaction-diffusion system modeling injection of a chemotherapeutic drug on the surface of a living tissue during a treatment for cancer patients is studied. The system describes the interaction of the chemotherapeutic drug…
We analyze the necrosis growth due to thermal coagulation induced by laser light absorption and limited by heat diffusion into the surrounding live tissue. The tissue is assumed to contain a certain tumor in the undamaged tissue whereof the…
Background: Experiments have reported low normal tissue toxicities during FLASH radiation, but the mechanism has not been elaborated. Several hypotheses have been proposed to explain the mechanism. The oxygen depletion hypothesis has been…
Background: FLASH radiotherapy is a treatment regime that delivers therapeutic dose to tumors at an ultra-high dose rate while maintaining adequate normal tissue sparing. However, a comprehensive understanding of the underlying mechanisms,…
This paper deals with the classic radiotherapy dose fractionation problem for cancer tumors concerning the following goals: a) To maximize the effect of radiation on the tumor, restricting the effect produced to the organs at risk (healing…
When high-intensity laser interaction with matter enters the regime of dominated radiation reaction, the radiation losses open the way for producing short pulse high power gamma ray flashes. The gamma-ray pulse duration and divergence are…
Purpose: The FLASH effect, which reduces the radiosensitivity of healthy tissue while maintaining tumor control at high dose rates, has shown potential for improving radiation therapy. Conformal FLASH proton therapy involves advanced…
We develop a quantitative model of ionization processes in biological tissues under Ultra High Dose Rate (UHDR) radiation. The underlying conjecture is that of electron-hole liquid (EHL) forming in water based substances of biological…
A novel laser cooling mechanism based on many body effects is presented. The method can be applicable for cooling a large class of atoms and molecules in higher density than commonly excepted by existing methods. The cooling mechanism…
The present paper deals with the study of the fluence rate over both healthy and tumor tissues in the presence of focal laser ablation (FLA). We propose new analytical solutions for the coupled partial differential equations (PDE) system,…
The Circular Electron-Positron Collider (CEPC) can also work as a powerful and excellent synchrotron light source, which can generate high-quality synchrotron radiation. This synchrotron radiation has potential advantages in the medical…
{\bf Purpose}: To develop a geometry-governed diffusion framework that explains differential tissue response under FLASH ultra-high dose rate (UHDR) irradiation by explicitly accounting for structural heterogeneity and anomalous transport…
While cancer has traditionally been considered a genetic disease, mounting evidence indicates an important role for non-genetic (epigenetic) mechanisms. Common anti-cancer drugs have recently been observed to induce the adoption of…
We know that stress-factors, e.g. X-rays, have an effect on cells that is more lethal in rapid exponential growth than in stationary phase. It is this effect which makes radiotherapy effective in cancer treatment. This stress effect can be…